A Case of Metformin-Associated Lactic Acidosis Complicated by Acute Liver Failure, Acute Renal Failure, and Shock
Metformin is an oral antihyperglycemic agent used for type 2 diabetes mellitus (T2DM) management and is considered to be the first-line treatment for diabetic patients. It works by improving insulin sensitivity, reducing intestinal absorption, and decreasing glucose production in the liver, leading...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e61911 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | e61911 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 16 |
| creator | Farouji, Abdelhadi Haddad, Ahmad W Kloub, Mohammad Paige, Amy Miller, Richard |
| description | Metformin is an oral antihyperglycemic agent used for type 2 diabetes mellitus (T2DM) management and is considered to be the first-line treatment for diabetic patients. It works by improving insulin sensitivity, reducing intestinal absorption, and decreasing glucose production in the liver, leading to decreased blood glucose levels. It is generally considered a safe drug; however, it is associated with an uncommon but serious side effect known as metformin-associated lactic acidosis (MALA), a potentially life-threatening condition. Patients with renal failure and liver disease are at high risk of developing MALA; therefore, the medication should be used cautiously in these patients. The diagnosis of MALA requires high suspicion from the physician of this specific entity; otherwise, it may be easily missed. Herein, we report a case of a 63-year-old female with alcoholic liver disease on metformin who was found to have MALA complicated by acute decompensated liver failure, renal failure, and shock. |
| doi_str_mv | 10.7759/cureus.61911 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11227902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086686732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-705f399635a6673e3a8a2176f5f3651ecaef59b803b09300f15d2b6f7a3ddd8d3</originalsourceid><addsrcrecordid>eNpdkc1PGzEQxa2KikSUG-fKUi8cWGqvs7b3VEURH5WCKkF7trz2GAy762DvIvHf45A0fJw8evPz08w8hI4oORWiqn-aMcKYTjmtKf2CpiXlspBUzvbe1RN0mNI9IYQSURJB9tGEyVpUM0Gn6HGOFzoBDg5fweBC7HxfzFMKxusBLF5qM3iD58bbkHzCi9CtWm9ee81z1scB8NI_QcTn2rd5nJOteA29bt9E3Vt8cxfMwzf01ek2weH2PUD_zs_-Li6L5Z-L34v5sjCMkKEQpHKsrjmrNOeCAdNSl1Rwl2VeUTAaXFU3krCG1PmHo5UtG-6EZtZaadkB-rXxXY1NB9ZAP0TdqlX0nY7PKmivPnZ6f6duw5OitCxFTcrscLx1iOFxhDSozicDbat7CGNSjAguOJdijf74hN6HMeYDrCmZmbzCmjrZUCaGlCK43TSUqHWeapOnes0z49_fb7CD_6fHXgBRHZws</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086686732</pqid></control><display><type>article</type><title>A Case of Metformin-Associated Lactic Acidosis Complicated by Acute Liver Failure, Acute Renal Failure, and Shock</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Farouji, Abdelhadi ; Haddad, Ahmad W ; Kloub, Mohammad ; Paige, Amy ; Miller, Richard</creator><creatorcontrib>Farouji, Abdelhadi ; Haddad, Ahmad W ; Kloub, Mohammad ; Paige, Amy ; Miller, Richard</creatorcontrib><description>Metformin is an oral antihyperglycemic agent used for type 2 diabetes mellitus (T2DM) management and is considered to be the first-line treatment for diabetic patients. It works by improving insulin sensitivity, reducing intestinal absorption, and decreasing glucose production in the liver, leading to decreased blood glucose levels. It is generally considered a safe drug; however, it is associated with an uncommon but serious side effect known as metformin-associated lactic acidosis (MALA), a potentially life-threatening condition. Patients with renal failure and liver disease are at high risk of developing MALA; therefore, the medication should be used cautiously in these patients. The diagnosis of MALA requires high suspicion from the physician of this specific entity; otherwise, it may be easily missed. Herein, we report a case of a 63-year-old female with alcoholic liver disease on metformin who was found to have MALA complicated by acute decompensated liver failure, renal failure, and shock.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.61911</identifier><identifier>PMID: 38975471</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Abdomen ; Acidosis ; Acids ; Analgesics ; Antibodies ; Antidiabetics ; Diabetes ; Drug overdose ; Endocrinology/Diabetes/Metabolism ; Etiology ; Gastroenterology ; Glucose ; Hemodialysis ; Hemoglobin ; Hepatitis ; Intensive care ; Internal Medicine ; Kidney diseases ; Laboratories ; Liver diseases ; Metabolism ; Mortality ; Nausea ; Patients ; Side effects ; Urine ; Vomiting</subject><ispartof>Curēus (Palo Alto, CA), 2024-06, Vol.16 (6), p.e61911</ispartof><rights>Copyright © 2024, Farouji et al.</rights><rights>Copyright © 2024, Farouji et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Farouji et al. 2024 Farouji et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-705f399635a6673e3a8a2176f5f3651ecaef59b803b09300f15d2b6f7a3ddd8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227902/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227902/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38975471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farouji, Abdelhadi</creatorcontrib><creatorcontrib>Haddad, Ahmad W</creatorcontrib><creatorcontrib>Kloub, Mohammad</creatorcontrib><creatorcontrib>Paige, Amy</creatorcontrib><creatorcontrib>Miller, Richard</creatorcontrib><title>A Case of Metformin-Associated Lactic Acidosis Complicated by Acute Liver Failure, Acute Renal Failure, and Shock</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Metformin is an oral antihyperglycemic agent used for type 2 diabetes mellitus (T2DM) management and is considered to be the first-line treatment for diabetic patients. It works by improving insulin sensitivity, reducing intestinal absorption, and decreasing glucose production in the liver, leading to decreased blood glucose levels. It is generally considered a safe drug; however, it is associated with an uncommon but serious side effect known as metformin-associated lactic acidosis (MALA), a potentially life-threatening condition. Patients with renal failure and liver disease are at high risk of developing MALA; therefore, the medication should be used cautiously in these patients. The diagnosis of MALA requires high suspicion from the physician of this specific entity; otherwise, it may be easily missed. Herein, we report a case of a 63-year-old female with alcoholic liver disease on metformin who was found to have MALA complicated by acute decompensated liver failure, renal failure, and shock.</description><subject>Abdomen</subject><subject>Acidosis</subject><subject>Acids</subject><subject>Analgesics</subject><subject>Antibodies</subject><subject>Antidiabetics</subject><subject>Diabetes</subject><subject>Drug overdose</subject><subject>Endocrinology/Diabetes/Metabolism</subject><subject>Etiology</subject><subject>Gastroenterology</subject><subject>Glucose</subject><subject>Hemodialysis</subject><subject>Hemoglobin</subject><subject>Hepatitis</subject><subject>Intensive care</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Liver diseases</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Nausea</subject><subject>Patients</subject><subject>Side effects</subject><subject>Urine</subject><subject>Vomiting</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1PGzEQxa2KikSUG-fKUi8cWGqvs7b3VEURH5WCKkF7trz2GAy762DvIvHf45A0fJw8evPz08w8hI4oORWiqn-aMcKYTjmtKf2CpiXlspBUzvbe1RN0mNI9IYQSURJB9tGEyVpUM0Gn6HGOFzoBDg5fweBC7HxfzFMKxusBLF5qM3iD58bbkHzCi9CtWm9ee81z1scB8NI_QcTn2rd5nJOteA29bt9E3Vt8cxfMwzf01ek2weH2PUD_zs_-Li6L5Z-L34v5sjCMkKEQpHKsrjmrNOeCAdNSl1Rwl2VeUTAaXFU3krCG1PmHo5UtG-6EZtZaadkB-rXxXY1NB9ZAP0TdqlX0nY7PKmivPnZ6f6duw5OitCxFTcrscLx1iOFxhDSozicDbat7CGNSjAguOJdijf74hN6HMeYDrCmZmbzCmjrZUCaGlCK43TSUqHWeapOnes0z49_fb7CD_6fHXgBRHZws</recordid><startdate>20240607</startdate><enddate>20240607</enddate><creator>Farouji, Abdelhadi</creator><creator>Haddad, Ahmad W</creator><creator>Kloub, Mohammad</creator><creator>Paige, Amy</creator><creator>Miller, Richard</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240607</creationdate><title>A Case of Metformin-Associated Lactic Acidosis Complicated by Acute Liver Failure, Acute Renal Failure, and Shock</title><author>Farouji, Abdelhadi ; Haddad, Ahmad W ; Kloub, Mohammad ; Paige, Amy ; Miller, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-705f399635a6673e3a8a2176f5f3651ecaef59b803b09300f15d2b6f7a3ddd8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdomen</topic><topic>Acidosis</topic><topic>Acids</topic><topic>Analgesics</topic><topic>Antibodies</topic><topic>Antidiabetics</topic><topic>Diabetes</topic><topic>Drug overdose</topic><topic>Endocrinology/Diabetes/Metabolism</topic><topic>Etiology</topic><topic>Gastroenterology</topic><topic>Glucose</topic><topic>Hemodialysis</topic><topic>Hemoglobin</topic><topic>Hepatitis</topic><topic>Intensive care</topic><topic>Internal Medicine</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Liver diseases</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Nausea</topic><topic>Patients</topic><topic>Side effects</topic><topic>Urine</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farouji, Abdelhadi</creatorcontrib><creatorcontrib>Haddad, Ahmad W</creatorcontrib><creatorcontrib>Kloub, Mohammad</creatorcontrib><creatorcontrib>Paige, Amy</creatorcontrib><creatorcontrib>Miller, Richard</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farouji, Abdelhadi</au><au>Haddad, Ahmad W</au><au>Kloub, Mohammad</au><au>Paige, Amy</au><au>Miller, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Metformin-Associated Lactic Acidosis Complicated by Acute Liver Failure, Acute Renal Failure, and Shock</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-06-07</date><risdate>2024</risdate><volume>16</volume><issue>6</issue><spage>e61911</spage><pages>e61911-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Metformin is an oral antihyperglycemic agent used for type 2 diabetes mellitus (T2DM) management and is considered to be the first-line treatment for diabetic patients. It works by improving insulin sensitivity, reducing intestinal absorption, and decreasing glucose production in the liver, leading to decreased blood glucose levels. It is generally considered a safe drug; however, it is associated with an uncommon but serious side effect known as metformin-associated lactic acidosis (MALA), a potentially life-threatening condition. Patients with renal failure and liver disease are at high risk of developing MALA; therefore, the medication should be used cautiously in these patients. The diagnosis of MALA requires high suspicion from the physician of this specific entity; otherwise, it may be easily missed. Herein, we report a case of a 63-year-old female with alcoholic liver disease on metformin who was found to have MALA complicated by acute decompensated liver failure, renal failure, and shock.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38975471</pmid><doi>10.7759/cureus.61911</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2024-06, Vol.16 (6), p.e61911 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11227902 |
| source | PubMed Central Open Access; PubMed Central |
| subjects | Abdomen Acidosis Acids Analgesics Antibodies Antidiabetics Diabetes Drug overdose Endocrinology/Diabetes/Metabolism Etiology Gastroenterology Glucose Hemodialysis Hemoglobin Hepatitis Intensive care Internal Medicine Kidney diseases Laboratories Liver diseases Metabolism Mortality Nausea Patients Side effects Urine Vomiting |
| title | A Case of Metformin-Associated Lactic Acidosis Complicated by Acute Liver Failure, Acute Renal Failure, and Shock |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A51%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Case%20of%20Metformin-Associated%20Lactic%20Acidosis%20Complicated%20by%20Acute%20Liver%20Failure,%20Acute%20Renal%20Failure,%20and%20Shock&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Farouji,%20Abdelhadi&rft.date=2024-06-07&rft.volume=16&rft.issue=6&rft.spage=e61911&rft.pages=e61911-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.61911&rft_dat=%3Cproquest_pubme%3E3086686732%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3086686732&rft_id=info:pmid/38975471&rfr_iscdi=true |