Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota

Shi et al. (2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒...

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Veröffentlicht in:Journal of investigative dermatology 2021-07, Vol.141 (7), p.1630-1632
1. Verfasser: Nayak, Renuka R.
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description Shi et al. (2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota.
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subjects Animals
Diet, Western - adverse effects
Gastrointestinal Microbiome
Joint Diseases
Mice
Psoriasis - etiology
Skin
title Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota
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