Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota
Shi et al. (2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒...
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Veröffentlicht in: | Journal of investigative dermatology 2021-07, Vol.141 (7), p.1630-1632 |
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description | Shi et al. (2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota. |
doi_str_mv | 10.1016/j.jid.2021.01.003 |
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(2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. 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(2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota.</description><subject>Animals</subject><subject>Diet, Western - adverse effects</subject><subject>Gastrointestinal Microbiome</subject><subject>Joint Diseases</subject><subject>Mice</subject><subject>Psoriasis - etiology</subject><subject>Skin</subject><issn>0022-202X</issn><issn>1523-1747</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1vFDEMjRCILoUfwAXlyGUWx5kkWzigqkABLaLiQ3ALacZLvZ2dlCRbiX9PypYKLkiWLNvvvTh-QjxUMFeg7JP1fM3DHAHVHFqAviVmyqDulOvdbTEDQOza-OueuFfKGhqnN4u7Yk_3yjqHOBPfvlCplCf5gqnKMA3ypKTMoXLslnxO8uM5T7_7bxNPtcEKhULlqTyUJ6nSVDmM8kMaSa5SlvWM5PG2ynccczrlVMN9cWcVxkIPrvO--Pzq5aej193y_fGbo8NlF3uDtXMUCByoVVQWrQMkexAMRHSLA2uDikEP2C-cbj2nyRmDEeKgWq1Qo9X74vlO92J7uqEhts1yGP1F5k3IP30K7P-dTHzmv6dLrxSiMdo0hcfXCjn92Laz-A2XSOMYJkrb4tH0xsJCa9egagdtvywl0-rmHQX-yhq_9s0af2WNhxagG-fR3wveMP540QDPdgBqZ7pkyr5EpinSwJli9UPi_8j_Aui3nac</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Nayak, Renuka R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1123-4668</orcidid></search><sort><creationdate>202107</creationdate><title>Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota</title><author>Nayak, Renuka R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-7eae0701fc1626702e69a50c278966a1ca3d2487350c73e7552c0cd1350123263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Diet, Western - adverse effects</topic><topic>Gastrointestinal Microbiome</topic><topic>Joint Diseases</topic><topic>Mice</topic><topic>Psoriasis - etiology</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nayak, Renuka R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nayak, Renuka R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2021-07</date><risdate>2021</risdate><volume>141</volume><issue>7</issue><spage>1630</spage><epage>1632</epage><pages>1630-1632</pages><issn>0022-202X</issn><issn>1523-1747</issn><eissn>1523-1747</eissn><abstract>Shi et al. (2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice” show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34167722</pmid><doi>10.1016/j.jid.2021.01.003</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-1123-4668</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Diet, Western - adverse effects Gastrointestinal Microbiome Joint Diseases Mice Psoriasis - etiology Skin |
title | Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota |
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