IsoVis - a webserver for visualization and annotation of alternative RNA isoforms

Genes commonly express multiple RNA products (RNA isoforms), which differ in exonic content and can have different functions. Making sense of the plethora of known and novel RNA isoforms being identified by transcriptomic approaches requires a user-friendly way to visualize gene isoforms and how the...

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Veröffentlicht in:Nucleic acids research 2024-05, Vol.52 (W1), p.W341-W347
Hauptverfasser: Wan, Ching Yin, Davis, Jack, Chauhan, Manveer, Gleeson, Josie, Prawer, Yair D J, De Paoli-Iseppi, Ricardo, Wells, Christine A, Choi, Jarny, Clark, Michael B
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container_issue W1
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container_title Nucleic acids research
container_volume 52
creator Wan, Ching Yin
Davis, Jack
Chauhan, Manveer
Gleeson, Josie
Prawer, Yair D J
De Paoli-Iseppi, Ricardo
Wells, Christine A
Choi, Jarny
Clark, Michael B
description Genes commonly express multiple RNA products (RNA isoforms), which differ in exonic content and can have different functions. Making sense of the plethora of known and novel RNA isoforms being identified by transcriptomic approaches requires a user-friendly way to visualize gene isoforms and how they differ in exonic content, expression levels and potential functions. Here we introduce IsoVis, a freely available webserver that accepts user-supplied transcriptomic data and visualizes the expressed isoforms in a clear, intuitive manner. IsoVis contains numerous features, including the ability to visualize all RNA isoforms of a gene and their expression levels; the annotation of known isoforms from external databases; mapping of protein domains and features to exons, allowing changes to protein sequence and function between isoforms to be established; and extensive species compatibility. Datasets visualised on IsoVis remain private to the user, allowing analysis of sensitive data. IsoVis visualisations can be downloaded to create publication-ready figures. The IsoVis webserver enables researchers to perform isoform analyses without requiring programming skills, is free to use, and available at https://isomix.org/isovis/.
doi_str_mv 10.1093/nar/gkae343
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title IsoVis - a webserver for visualization and annotation of alternative RNA isoforms
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