$Targeting IL-1 controls refractory pityriasis rubra pilaris$

Targeting IL-1 controls refractory pityriasis rubra pilaris

Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease with a poorly understood pathogenesis. Through a molecularly driven precision medicine approach and an extensive mechanistic pathway analysis in PRP skin samples, compared to psoriasis, atopic dermatitis, healed PRP, and healthy cont...

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Veröffentlicht in:	Science advances 2024-07, Vol.10 (27), p.eado2365
Hauptverfasser:	Schmauch, Eloi, Severin, Yannik, Xing, Xianying, Mangold, Aaron, Conrad, Curdin, Johannsen, Pål, Kahlenberg, J Michelle, Mellett, Mark, Navarini, Alexander, Nobbe, Stefan, Sarkar, Mrinal K, Satyam, Abhigyan, Tsoi, Lam C, French, Lars E, Nilsson, Jakob, Linna-Kuosmanen, Suvi, Kaikkonen, Minna U, Snijder, Berend, Kellis, Manolis, Gudjonsson, Johann E, Tsokos, George C, Contassot, Emmanuel, Kolios, Antonios G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Biomedicine and Life Sciences CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - metabolism Female Guanylate Cyclase - antagonists & inhibitors Guanylate Cyclase - genetics Guanylate Cyclase - metabolism Humans Immunology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-1 - antagonists & inhibitors Interleukin-1 - genetics Interleukin-1 - metabolism Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - metabolism Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - pathology Male Membrane Proteins Middle Aged NF-kappa B - metabolism Nod2 Signaling Adaptor Protein - antagonists & inhibitors Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism Pityriasis Rubra Pilaris - drug therapy Pityriasis Rubra Pilaris - genetics Pityriasis Rubra Pilaris - pathology SciAdv r-articles Signal Transduction - drug effects Skin - drug effects Skin - metabolism Skin - pathology
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