A randomized phase II clinical trial of stereotactic body radiation therapy (SBRT) and systemic pembrolizumab with or without intratumoral avelumab/ipilimumab plus CD1c (BDCA-1)+/CD141 (BDCA-3)+ myeloid dendritic cells in solid tumors

Background Radiotherapy (RT) synergizes with immune checkpoint blockade (ICB). CD1c(BDCA-1) + /CD141(BDCA-3) + myeloid dendritic cells (myDC) in the tumor microenvironment are indispensable at initiating effector T-cell responses and response to ICB. Methods In this phase II clinical trial, anti-PD-...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy : CII Immunotherapy : CII, 2024-07, Vol.73 (9), p.167, Article 167
Hauptverfasser:	Vounckx, Manon, Tijtgat, Jens, Stevens, Latoya, Dirven, Iris, Ilsen, Bart, Vandenbroucke, Frederik, Raeymaeckers, Steven, Vekens, Karolien, Forsyth, Ramses, Geeraerts, Xenia, Van Riet, Ivan, Schwarze, Julia Katharina, Tuyaerts, Sandra, Decoster, Lore, De Ridder, Mark, Dufait, Ines, Neyns, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - therapeutic use Antigens, CD1 Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Research CD1c antigen Clinical trials Combined Modality Therapy Dendritic cells Dendritic Cells - immunology Effector cells Female Glycoproteins Humans Immune checkpoint inhibitors Immunology Ipilimumab - administration & dosage Ipilimumab - therapeutic use Leukapheresis Lymphocytes T Male Medicine Medicine & Public Health Melanoma Metastasis Middle Aged Myeloid Cells NCT NCT04571632 Neoplasms - immunology Neoplasms - therapy Non-small cell lung carcinoma Oncology Patients PD-1 protein Pembrolizumab Pneumothorax Radiation therapy Radiosurgery - methods Response rates Small cell lung carcinoma Solid tumors Thrombomodulin - therapeutic use Tumor microenvironment
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