Disengagement of Somatostatin Neurons From Lateral Septum Circuitry by Oxytocin and Vasopressin Restores Social Fear Extinction and Suppresses Aggression Outbursts in a Prader-Willi Syndrome Model

Responding to social signals by expressing the correct behavior is not only challenged in autism but also in diseases with a high prevalence of autism, such as Prader-Willi syndrome. Clinical evidence suggests that aberrant prosocial behavior in patients can be regulated by intranasal oxytocin (OXT)...

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Veröffentlicht in:	Biological psychiatry (1969) 2024-04, Vol.95 (8), p.785-799
Hauptverfasser:	Dromard, Yann, Borie, Amélie M., Chakraborty, Prabahan, Muscatelli, Françoise, Guillon, Gilles, Desarménien, Michel G., Jeanneteau, Freddy
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression Aggression - drug effects Aggression - physiology Animals Autism Disease Models, Animal Extinction Extinction, Psychological - drug effects Extinction, Psychological - physiology Fear - drug effects Fear - physiology Intracellular Signaling Peptides and Proteins Intrinsically Disordered Proteins Lateral septum Life Sciences Male Mice Mice, Inbred C57BL Mice, Knockout Neurons - drug effects Neurons - metabolism Optogenetics Oxytocin - pharmacology Prader-Willi Syndrome - drug therapy Prader-Willi Syndrome - physiopathology Septal Nuclei - drug effects Septal Nuclei - metabolism Social Behavior Social fear Somatostatin - metabolism Somatostatin - pharmacology Vasopressins - metabolism
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