Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

Cerebral oedema is associated with morbidity and mortality after traumatic brain injury (TBI) 1 . Noradrenaline levels are increased after TBI 2 – 4 , and the amplitude of the increase in noradrenaline predicts both the extent of injury 5 and the likelihood of mortality 6 . Glymphatic impairment is...

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Veröffentlicht in:	Nature (London) 2023-11, Vol.623 (7989), p.992-1000
Hauptverfasser:	Hussain, Rashad, Tithof, Jeffrey, Wang, Wei, Cheetham-West, Arokoruba, Song, Wei, Peng, Weiguo, Sigurdsson, Björn, Kim, Daehyun, Sun, Qian, Peng, Sisi, Plá, Virginia, Kelley, Douglas H., Hirase, Hajime, Castorena-Gonzalez, Jorge A., Weikop, Pia, Goldman, Steven A., Davis, Michael J., Nedergaard, Maiken
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 14/34 14/35 14/63 14/69 631/378/1687 631/443/376 64/60 82/29 96/1 96/2 Adrenergic Antagonists - pharmacology Adrenergic Antagonists - therapeutic use Adrenergic receptors Animals Blood vessels Blood-brain barrier Brain Brain Edema - complications Brain Edema - drug therapy Brain Edema - metabolism Brain Edema - prevention & control Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - metabolism Chemokines Contractility Disease Models, Animal Edema Fluid flow Glymphatic System - drug effects Glymphatic System - metabolism Head injuries Humanities and Social Sciences Inflammation - complications Inflammation - drug therapy Inflammation - metabolism Inflammation - prevention & control Lymphatic drainage Lymphatic system Lymphatic Vessels - metabolism Mice Morbidity multidisciplinary Noradrenaline Norepinephrine Norepinephrine - metabolism Phosphorylation Receptors (physiology) Receptors, Adrenergic - metabolism Science Science (multidisciplinary) Traumatic brain injury
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