The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions
Abstract Objectives The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in E...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2024-07, Vol.79 (7), p.1619-1627 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 79 |
| creator | Mwalwisi, Yonah Hebron Fimbo, Adam Mitangu Hoellein, Ludwig Nandonde, Moses Sambu, Gerald Ahmed, Babuali Juma, Abdalla Augustine, Siya Shewiyo, Danstan Hipolite Kaale, Eliangiringa Amos Holzgrabe, Ulrike |
| description | Abstract
Objectives
The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in Europe are of superior quality to those originating from Africa or Asia.
Methods
Samples of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets were collected from three randomly selected wholesale pharmacies in each city, namely Arusha, Dar es Salaam and Mwanza, Tanzania. The collected samples of collected brands were subjected to quality control testing as per their respective pharmacopoeial monographs. Amoxil 250 mg capsules (Glaxo Wellcome, Mayenne, France), Rocephin (Roche, Switzerland) and Cipro-Denk 500 (Allphamed Pharbil Arzneimittel GmbH, Gottingen, Germany) were used as reference brands for the other generic brands of amoxicillin, ceftriaxone and ciprofloxacin, respectively.
Results
A total of 31 brands (10 different brands of amoxicillin capsules, 9 of ceftriaxone sodium injections, and 12 of ciprofloxacin tablets) were collected from the targeted regions and subjected to quality control testing. All samples of collected brands complied with the requirements of their respective pharmacopoeial monographs.
Conclusions
There was no significant difference in quality between brands of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets manufactured in Africa and Asia against those manufactured in Europe in terms of compliance with the respective pharmacopoeial monographs. |
| doi_str_mv | 10.1093/jac/dkae155 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11215545</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jac/dkae155</oup_id><sourcerecordid>3061137450</sourcerecordid><originalsourceid>FETCH-LOGICAL-c301t-4d76cf6ae0434294f5b49afbc637892fe3b69bce77bdea9c6342066d8c6190753</originalsourceid><addsrcrecordid>eNp9kUFv1DAQhS0EokvhxB35hJCqUDt2nPiEUEUBqRKX5WxNnPGuS2KndlJUfj1e7VLBhdNo3nx6M5pHyGvO3nOmxeUt2MvhByBvmidkw6ViVc00f0o2TLCmamUjzsiLnG8ZY6pR3XNyJrqOSS71hvzc7pHaOM2QfI6BRkeXotytMPrl4dBmHNEuONA-QRjyQYKw-N7HxdtMfaBbCL8geKA5rskW0qU40cE7hwnDQncYdwnmvbcw0oQ7H0N-SZ45GDO-OtVz8v360_bqS3Xz7fPXq483lRWML5UcWmWdAmRSyFpL1_RSg-utEm2na4eiV7q32Lb9gKCLLGum1NBZxTVrG3FOPhx957WfcLDlngSjmZOfID2YCN78Owl-b3bx3nBel4fKg8O7k0OKdyvmxUw-WxxHCBjXbARTnIvyZVbQiyNqU8w5oXvcw5k5ZGVKVuaUVaHf_H3aI_snnAK8PQJxnf_r9BsQT6Ds</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3061137450</pqid></control><display><type>article</type><title>The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><creator>Mwalwisi, Yonah Hebron ; Fimbo, Adam Mitangu ; Hoellein, Ludwig ; Nandonde, Moses ; Sambu, Gerald ; Ahmed, Babuali ; Juma, Abdalla ; Augustine, Siya ; Shewiyo, Danstan Hipolite ; Kaale, Eliangiringa Amos ; Holzgrabe, Ulrike</creator><creatorcontrib>Mwalwisi, Yonah Hebron ; Fimbo, Adam Mitangu ; Hoellein, Ludwig ; Nandonde, Moses ; Sambu, Gerald ; Ahmed, Babuali ; Juma, Abdalla ; Augustine, Siya ; Shewiyo, Danstan Hipolite ; Kaale, Eliangiringa Amos ; Holzgrabe, Ulrike</creatorcontrib><description>Abstract
Objectives
The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in Europe are of superior quality to those originating from Africa or Asia.
Methods
Samples of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets were collected from three randomly selected wholesale pharmacies in each city, namely Arusha, Dar es Salaam and Mwanza, Tanzania. The collected samples of collected brands were subjected to quality control testing as per their respective pharmacopoeial monographs. Amoxil 250 mg capsules (Glaxo Wellcome, Mayenne, France), Rocephin (Roche, Switzerland) and Cipro-Denk 500 (Allphamed Pharbil Arzneimittel GmbH, Gottingen, Germany) were used as reference brands for the other generic brands of amoxicillin, ceftriaxone and ciprofloxacin, respectively.
Results
A total of 31 brands (10 different brands of amoxicillin capsules, 9 of ceftriaxone sodium injections, and 12 of ciprofloxacin tablets) were collected from the targeted regions and subjected to quality control testing. All samples of collected brands complied with the requirements of their respective pharmacopoeial monographs.
Conclusions
There was no significant difference in quality between brands of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets manufactured in Africa and Asia against those manufactured in Europe in terms of compliance with the respective pharmacopoeial monographs.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkae155</identifier><identifier>PMID: 38804149</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><subject>Amoxicillin - analysis ; Amoxicillin - chemistry ; Amoxicillin - standards ; Anti-Bacterial Agents - analysis ; Ceftriaxone - analysis ; Ceftriaxone - chemistry ; Ciprofloxacin - analysis ; Humans ; Original Research ; Quality Control ; Tablets ; Tanzania</subject><ispartof>Journal of antimicrobial chemotherapy, 2024-07, Vol.79 (7), p.1619-1627</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c301t-4d76cf6ae0434294f5b49afbc637892fe3b69bce77bdea9c6342066d8c6190753</cites><orcidid>0000-0001-6008-3539 ; 0000-0002-0364-7278</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38804149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mwalwisi, Yonah Hebron</creatorcontrib><creatorcontrib>Fimbo, Adam Mitangu</creatorcontrib><creatorcontrib>Hoellein, Ludwig</creatorcontrib><creatorcontrib>Nandonde, Moses</creatorcontrib><creatorcontrib>Sambu, Gerald</creatorcontrib><creatorcontrib>Ahmed, Babuali</creatorcontrib><creatorcontrib>Juma, Abdalla</creatorcontrib><creatorcontrib>Augustine, Siya</creatorcontrib><creatorcontrib>Shewiyo, Danstan Hipolite</creatorcontrib><creatorcontrib>Kaale, Eliangiringa Amos</creatorcontrib><creatorcontrib>Holzgrabe, Ulrike</creatorcontrib><title>The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Abstract
Objectives
The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in Europe are of superior quality to those originating from Africa or Asia.
Methods
Samples of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets were collected from three randomly selected wholesale pharmacies in each city, namely Arusha, Dar es Salaam and Mwanza, Tanzania. The collected samples of collected brands were subjected to quality control testing as per their respective pharmacopoeial monographs. Amoxil 250 mg capsules (Glaxo Wellcome, Mayenne, France), Rocephin (Roche, Switzerland) and Cipro-Denk 500 (Allphamed Pharbil Arzneimittel GmbH, Gottingen, Germany) were used as reference brands for the other generic brands of amoxicillin, ceftriaxone and ciprofloxacin, respectively.
Results
A total of 31 brands (10 different brands of amoxicillin capsules, 9 of ceftriaxone sodium injections, and 12 of ciprofloxacin tablets) were collected from the targeted regions and subjected to quality control testing. All samples of collected brands complied with the requirements of their respective pharmacopoeial monographs.
Conclusions
There was no significant difference in quality between brands of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets manufactured in Africa and Asia against those manufactured in Europe in terms of compliance with the respective pharmacopoeial monographs.</description><subject>Amoxicillin - analysis</subject><subject>Amoxicillin - chemistry</subject><subject>Amoxicillin - standards</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Ceftriaxone - analysis</subject><subject>Ceftriaxone - chemistry</subject><subject>Ciprofloxacin - analysis</subject><subject>Humans</subject><subject>Original Research</subject><subject>Quality Control</subject><subject>Tablets</subject><subject>Tanzania</subject><issn>0305-7453</issn><issn>1460-2091</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EokvhxB35hJCqUDt2nPiEUEUBqRKX5WxNnPGuS2KndlJUfj1e7VLBhdNo3nx6M5pHyGvO3nOmxeUt2MvhByBvmidkw6ViVc00f0o2TLCmamUjzsiLnG8ZY6pR3XNyJrqOSS71hvzc7pHaOM2QfI6BRkeXotytMPrl4dBmHNEuONA-QRjyQYKw-N7HxdtMfaBbCL8geKA5rskW0qU40cE7hwnDQncYdwnmvbcw0oQ7H0N-SZ45GDO-OtVz8v360_bqS3Xz7fPXq483lRWML5UcWmWdAmRSyFpL1_RSg-utEm2na4eiV7q32Lb9gKCLLGum1NBZxTVrG3FOPhx957WfcLDlngSjmZOfID2YCN78Owl-b3bx3nBel4fKg8O7k0OKdyvmxUw-WxxHCBjXbARTnIvyZVbQiyNqU8w5oXvcw5k5ZGVKVuaUVaHf_H3aI_snnAK8PQJxnf_r9BsQT6Ds</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Mwalwisi, Yonah Hebron</creator><creator>Fimbo, Adam Mitangu</creator><creator>Hoellein, Ludwig</creator><creator>Nandonde, Moses</creator><creator>Sambu, Gerald</creator><creator>Ahmed, Babuali</creator><creator>Juma, Abdalla</creator><creator>Augustine, Siya</creator><creator>Shewiyo, Danstan Hipolite</creator><creator>Kaale, Eliangiringa Amos</creator><creator>Holzgrabe, Ulrike</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6008-3539</orcidid><orcidid>https://orcid.org/0000-0002-0364-7278</orcidid></search><sort><creationdate>20240701</creationdate><title>The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions</title><author>Mwalwisi, Yonah Hebron ; Fimbo, Adam Mitangu ; Hoellein, Ludwig ; Nandonde, Moses ; Sambu, Gerald ; Ahmed, Babuali ; Juma, Abdalla ; Augustine, Siya ; Shewiyo, Danstan Hipolite ; Kaale, Eliangiringa Amos ; Holzgrabe, Ulrike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-4d76cf6ae0434294f5b49afbc637892fe3b69bce77bdea9c6342066d8c6190753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amoxicillin - analysis</topic><topic>Amoxicillin - chemistry</topic><topic>Amoxicillin - standards</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Ceftriaxone - analysis</topic><topic>Ceftriaxone - chemistry</topic><topic>Ciprofloxacin - analysis</topic><topic>Humans</topic><topic>Original Research</topic><topic>Quality Control</topic><topic>Tablets</topic><topic>Tanzania</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mwalwisi, Yonah Hebron</creatorcontrib><creatorcontrib>Fimbo, Adam Mitangu</creatorcontrib><creatorcontrib>Hoellein, Ludwig</creatorcontrib><creatorcontrib>Nandonde, Moses</creatorcontrib><creatorcontrib>Sambu, Gerald</creatorcontrib><creatorcontrib>Ahmed, Babuali</creatorcontrib><creatorcontrib>Juma, Abdalla</creatorcontrib><creatorcontrib>Augustine, Siya</creatorcontrib><creatorcontrib>Shewiyo, Danstan Hipolite</creatorcontrib><creatorcontrib>Kaale, Eliangiringa Amos</creatorcontrib><creatorcontrib>Holzgrabe, Ulrike</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mwalwisi, Yonah Hebron</au><au>Fimbo, Adam Mitangu</au><au>Hoellein, Ludwig</au><au>Nandonde, Moses</au><au>Sambu, Gerald</au><au>Ahmed, Babuali</au><au>Juma, Abdalla</au><au>Augustine, Siya</au><au>Shewiyo, Danstan Hipolite</au><au>Kaale, Eliangiringa Amos</au><au>Holzgrabe, Ulrike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>79</volume><issue>7</issue><spage>1619</spage><epage>1627</epage><pages>1619-1627</pages><issn>0305-7453</issn><issn>1460-2091</issn><eissn>1460-2091</eissn><abstract>Abstract
Objectives
The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in Europe are of superior quality to those originating from Africa or Asia.
Methods
Samples of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets were collected from three randomly selected wholesale pharmacies in each city, namely Arusha, Dar es Salaam and Mwanza, Tanzania. The collected samples of collected brands were subjected to quality control testing as per their respective pharmacopoeial monographs. Amoxil 250 mg capsules (Glaxo Wellcome, Mayenne, France), Rocephin (Roche, Switzerland) and Cipro-Denk 500 (Allphamed Pharbil Arzneimittel GmbH, Gottingen, Germany) were used as reference brands for the other generic brands of amoxicillin, ceftriaxone and ciprofloxacin, respectively.
Results
A total of 31 brands (10 different brands of amoxicillin capsules, 9 of ceftriaxone sodium injections, and 12 of ciprofloxacin tablets) were collected from the targeted regions and subjected to quality control testing. All samples of collected brands complied with the requirements of their respective pharmacopoeial monographs.
Conclusions
There was no significant difference in quality between brands of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets manufactured in Africa and Asia against those manufactured in Europe in terms of compliance with the respective pharmacopoeial monographs.</abstract><cop>UK</cop><pub>Oxford University Press</pub><pmid>38804149</pmid><doi>10.1093/jac/dkae155</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6008-3539</orcidid><orcidid>https://orcid.org/0000-0002-0364-7278</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 2024-07, Vol.79 (7), p.1619-1627 |
| issn | 0305-7453 1460-2091 1460-2091 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11215545 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Amoxicillin - analysis Amoxicillin - chemistry Amoxicillin - standards Anti-Bacterial Agents - analysis Ceftriaxone - analysis Ceftriaxone - chemistry Ciprofloxacin - analysis Humans Original Research Quality Control Tablets Tanzania |
| title | The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions |
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