Global Immune-Nutrition-Information Index Is Independent Prognostic Factor for Gastric Cancer Patients Who Received Curative Treatment
The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with gastric cancer (GC) who received curative treatment and to clarify the potential of the GINI as a biomarker. Patients who underwent curative resection for GC at Y...
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| Veröffentlicht in: | Cancer diagnosis & prognosis 2024-07, Vol.4 (4), p.489-495 |
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| creator | Aoyama, Toru Hashimoto, Itaru Maezawa, Yukio Hara, Kentaro Yamamoto, Sosuke Esashi, Ryuki Tamagawa, Ayako Cho, Haruhiko Tanabe, Mie Morita, Jyunya Numata, Masakatsu Kawahara, Shinnosuke Oshima, Takashi Saito, Aya Yukawa, Norio |
| description | The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with gastric cancer (GC) who received curative treatment and to clarify the potential of the GINI as a biomarker.
Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were selected based on their medical records. The GINI was calculated as follows: GINI=[C-reactive protein × platelet × monocyte × neutrophil]/[albumin × lymphocyte].
A total of 258 patients were included in this study. Of these, 169 patients were categorized into the GINI-low group and 89 into the GINI-high group using a cut-off value of 1,730. The three- and five-year overall survival (OS) rates were 86.4% and 78.4%, respectively, in the GINI-low group, and 66.4% and 58.3% in the GINI-high group (p |
| doi_str_mv | 10.21873/cdp.10353 |
| format | Article |
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Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were selected based on their medical records. The GINI was calculated as follows: GINI=[C-reactive protein × platelet × monocyte × neutrophil]/[albumin × lymphocyte].
A total of 258 patients were included in this study. Of these, 169 patients were categorized into the GINI-low group and 89 into the GINI-high group using a cut-off value of 1,730. The three- and five-year overall survival (OS) rates were 86.4% and 78.4%, respectively, in the GINI-low group, and 66.4% and 58.3% in the GINI-high group (p<0.001). In a multivariate analysis for OS, the GINI was identified as an independent prognostic factor [hazard ratio (HR)=1.772; 95% confidence interval (CI)=1.053-2.979, p=0.031]. Similar results were observed for RFS. In addition, the GINI affected the perioperative clinical course, including postoperative surgical complications and postoperative adjuvant treatment.
The GINI is a promising biomarker for the treatment and management of GC.</description><identifier>ISSN: 2732-7787</identifier><identifier>EISSN: 2732-7787</identifier><identifier>DOI: 10.21873/cdp.10353</identifier><identifier>PMID: 38962545</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><ispartof>Cancer diagnosis & prognosis, 2024-07, Vol.4 (4), p.489-495</ispartof><rights>Copyright 2024, International Institute of Anticancer Research.</rights><rights>Copyright 2024, International Institute of Anticancer Research 2024</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215449/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215449/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38962545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Hashimoto, Itaru</creatorcontrib><creatorcontrib>Maezawa, Yukio</creatorcontrib><creatorcontrib>Hara, Kentaro</creatorcontrib><creatorcontrib>Yamamoto, Sosuke</creatorcontrib><creatorcontrib>Esashi, Ryuki</creatorcontrib><creatorcontrib>Tamagawa, Ayako</creatorcontrib><creatorcontrib>Cho, Haruhiko</creatorcontrib><creatorcontrib>Tanabe, Mie</creatorcontrib><creatorcontrib>Morita, Jyunya</creatorcontrib><creatorcontrib>Numata, Masakatsu</creatorcontrib><creatorcontrib>Kawahara, Shinnosuke</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><creatorcontrib>Saito, Aya</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><title>Global Immune-Nutrition-Information Index Is Independent Prognostic Factor for Gastric Cancer Patients Who Received Curative Treatment</title><title>Cancer diagnosis & prognosis</title><addtitle>Cancer Diagn Progn</addtitle><description>The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with gastric cancer (GC) who received curative treatment and to clarify the potential of the GINI as a biomarker.
Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were selected based on their medical records. The GINI was calculated as follows: GINI=[C-reactive protein × platelet × monocyte × neutrophil]/[albumin × lymphocyte].
A total of 258 patients were included in this study. Of these, 169 patients were categorized into the GINI-low group and 89 into the GINI-high group using a cut-off value of 1,730. The three- and five-year overall survival (OS) rates were 86.4% and 78.4%, respectively, in the GINI-low group, and 66.4% and 58.3% in the GINI-high group (p<0.001). In a multivariate analysis for OS, the GINI was identified as an independent prognostic factor [hazard ratio (HR)=1.772; 95% confidence interval (CI)=1.053-2.979, p=0.031]. Similar results were observed for RFS. In addition, the GINI affected the perioperative clinical course, including postoperative surgical complications and postoperative adjuvant treatment.
The GINI is a promising biomarker for the treatment and management of GC.</description><issn>2732-7787</issn><issn>2732-7787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVkd1q3DAQhUVJ6YZ0b_oARZcl4FS_kXxVwpJsDCFdypZeClkeZx1saSPZS_oCfe6ou0lIbmYO0jdnBg5CXyg5Y1Qr_t012zNKuOQf0DFTnBVKaXX0Rs_QPKV7QggrGadMf0IzrstzJoU8Rv-Wfahtj6thmDwUt9MYu7ELvqh8G-Jg_2tc-QYecZX2Ygu5-BGvYrjzIY2dw1fWjSHiPICXNmUHhxfWO4h4lQ0ynPCfTcC_wEG3gwYvppjfd4DXEew4ZOAz-tjaPsH8uZ-g31eX68V1cfNzWS0ubgpHhSoLyYkivD4vOWFctKqpJdWU5qa1k6VraqYbaKkmLWuFbsERWdeKCgJMEA38BP04-G6neoDG5dXR9mYbu8HGvybYzrz_8d3G3IWdoZRRKUSZHb49O8TwMEEazdAlB31vPYQpmXyhVEQwSTN6ekBdDClFaF_3UGL24ZkcntmHl-Gvby97RV-i4k_Iapdl</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Aoyama, Toru</creator><creator>Hashimoto, Itaru</creator><creator>Maezawa, Yukio</creator><creator>Hara, Kentaro</creator><creator>Yamamoto, Sosuke</creator><creator>Esashi, Ryuki</creator><creator>Tamagawa, Ayako</creator><creator>Cho, Haruhiko</creator><creator>Tanabe, Mie</creator><creator>Morita, Jyunya</creator><creator>Numata, Masakatsu</creator><creator>Kawahara, Shinnosuke</creator><creator>Oshima, Takashi</creator><creator>Saito, Aya</creator><creator>Yukawa, Norio</creator><general>International Institute of Anticancer Research</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202407</creationdate><title>Global Immune-Nutrition-Information Index Is Independent Prognostic Factor for Gastric Cancer Patients Who Received Curative Treatment</title><author>Aoyama, Toru ; Hashimoto, Itaru ; Maezawa, Yukio ; Hara, Kentaro ; Yamamoto, Sosuke ; Esashi, Ryuki ; Tamagawa, Ayako ; Cho, Haruhiko ; Tanabe, Mie ; Morita, Jyunya ; Numata, Masakatsu ; Kawahara, Shinnosuke ; Oshima, Takashi ; Saito, Aya ; Yukawa, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1479-530703b6930234f7db51811db588c59cdb28def180f2f48fec05bb7140e2408e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Hashimoto, Itaru</creatorcontrib><creatorcontrib>Maezawa, Yukio</creatorcontrib><creatorcontrib>Hara, Kentaro</creatorcontrib><creatorcontrib>Yamamoto, Sosuke</creatorcontrib><creatorcontrib>Esashi, Ryuki</creatorcontrib><creatorcontrib>Tamagawa, Ayako</creatorcontrib><creatorcontrib>Cho, Haruhiko</creatorcontrib><creatorcontrib>Tanabe, Mie</creatorcontrib><creatorcontrib>Morita, Jyunya</creatorcontrib><creatorcontrib>Numata, Masakatsu</creatorcontrib><creatorcontrib>Kawahara, Shinnosuke</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><creatorcontrib>Saito, Aya</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer diagnosis & prognosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoyama, Toru</au><au>Hashimoto, Itaru</au><au>Maezawa, Yukio</au><au>Hara, Kentaro</au><au>Yamamoto, Sosuke</au><au>Esashi, Ryuki</au><au>Tamagawa, Ayako</au><au>Cho, Haruhiko</au><au>Tanabe, Mie</au><au>Morita, Jyunya</au><au>Numata, Masakatsu</au><au>Kawahara, Shinnosuke</au><au>Oshima, Takashi</au><au>Saito, Aya</au><au>Yukawa, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Global Immune-Nutrition-Information Index Is Independent Prognostic Factor for Gastric Cancer Patients Who Received Curative Treatment</atitle><jtitle>Cancer diagnosis & prognosis</jtitle><addtitle>Cancer Diagn Progn</addtitle><date>2024-07</date><risdate>2024</risdate><volume>4</volume><issue>4</issue><spage>489</spage><epage>495</epage><pages>489-495</pages><issn>2732-7787</issn><eissn>2732-7787</eissn><abstract>The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with gastric cancer (GC) who received curative treatment and to clarify the potential of the GINI as a biomarker.
Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were selected based on their medical records. The GINI was calculated as follows: GINI=[C-reactive protein × platelet × monocyte × neutrophil]/[albumin × lymphocyte].
A total of 258 patients were included in this study. Of these, 169 patients were categorized into the GINI-low group and 89 into the GINI-high group using a cut-off value of 1,730. The three- and five-year overall survival (OS) rates were 86.4% and 78.4%, respectively, in the GINI-low group, and 66.4% and 58.3% in the GINI-high group (p<0.001). In a multivariate analysis for OS, the GINI was identified as an independent prognostic factor [hazard ratio (HR)=1.772; 95% confidence interval (CI)=1.053-2.979, p=0.031]. Similar results were observed for RFS. In addition, the GINI affected the perioperative clinical course, including postoperative surgical complications and postoperative adjuvant treatment.
The GINI is a promising biomarker for the treatment and management of GC.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>38962545</pmid><doi>10.21873/cdp.10353</doi><tpages>7</tpages></addata></record> |
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| title | Global Immune-Nutrition-Information Index Is Independent Prognostic Factor for Gastric Cancer Patients Who Received Curative Treatment |
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