A Bioorthogonal Small Molecule Selective Polymeric “Clickase”

Synthetic polymer scaffolds may serve as gatekeepers preventing the adhesion of biomacromolecules. Herein, we use gating to develop a copper-containing single-chain nanoparticle (SCNP) catalyst as an artificial “clickase” that operates selectively on small molecules that are able to penetrate the po...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-08, Vol.142 (32), p.13966-13973
Hauptverfasser:	Chen, Junfeng, Li, Ke, Bonson, Sarah E, Zimmerman, Steven C
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbonic Anhydrase II - chemistry Carbonic Anhydrase II - metabolism Catalysis Click Chemistry Copper - chemistry HeLa Cells Humans Ligands Metal Nanoparticles - chemistry Models, Molecular Molecular Structure Polymers - chemical synthesis Polymers - chemistry Small Molecule Libraries - chemistry
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