TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation

Sterile inflammation, also known as 'inflammaging', is a hallmark of tissue aging. Cellular senescence contributes to tissue aging, in part, through the secretion of proinflammatory factors collectively known as the senescence-associated secretory phenotype (SASP). The genetic variability...

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Veröffentlicht in:	Nature aging 2024-02, Vol.4 (2), p.185-197
Hauptverfasser:	Hao, Xue, Zhao, Bo, Towers, Martina, Liao, Liping, Monteiro, Edgar Luzete, Xu, Xin, Freeman, Christina, Peng, Hongzhuang, Tang, Hsin-Yao, Havas, Aaron, Kossenkov, Andrew V, Berger, Shelley L, Adams, Peter D, Speicher, David W, Schultz, David, Marmorstein, Ronen, Zaret, Kenneth S, Zhang, Rugang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Cellular Senescence - genetics Gene expression Immunity, Innate - genetics Inflammation Inflammation - genetics Localization Mice Nucleotidyltransferases - genetics Senescence Signal Transduction Thioredoxin Reductase 1 - metabolism
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