Risk factors for infectious complications after gastrectomy in older patients
The present study aimed to identify preoperative and perioperative risk factors for postoperative infectious complications in older patients with gastric cancer. The present retrospective study included 504 patients with gastric cancer aged >65 years who underwent radical gastrectomy. After deter...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2024-08, Vol.28 (2), p.319, Article 319 |
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| creator | Iida, Michihisa Takeda, Shigeru Yamamoto, Tsunenori Nakashima, Chiyo Nishiyama, Mitsuo Watanabe, Yusaku Shindo, Yoshitaro Tokumitsu, Yukio Tomochika, Shinobu Nakagami, Yuki Takahashi, Hidenori Nagano, Hiroaki |
| description | The present study aimed to identify preoperative and perioperative risk factors for postoperative infectious complications in older patients with gastric cancer. The present retrospective study included 504 patients with gastric cancer aged >65 years who underwent radical gastrectomy. After determining the cutoff values for various perioperative factors in the receiver operating characteristic curve analysis, preoperative and perioperative risk factors for the development of infectious complications after gastrectomy were examined using logistic regression analysis. Of the 504 patients who underwent gastrectomy, 95 (18.8%) developed infectious complications of grade II-V based on the Clavien-Dindo classification. In an analysis restricted to preoperative factors, male sex, low prognostic nutritional index, high visceral fat area and total gastrectomy were independent risk factors for infectious complications after gastrectomy. Among all perioperative factors, a low prognostic nutritional index and long operative duration were identified as independent risk factors for infectious complications after gastrectomy. The patients were divided into five groups according to the number of positive preoperative risk factors for infectious complications, and the incidence of infectious complications differed among the five groups (0 factors, 6.7%; 1 factor, 10.4%; 2 factors, 18.9%; 3 factors, 27.8%; and 4 factors, 47.6%; P |
| doi_str_mv | 10.3892/etm.2024.12608 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11208990</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A806500523</galeid><sourcerecordid>A806500523</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-ed53eec0a18b38a4485c66f3cbbd1698ac4b292a449cbe55fbc8308941783ce43</originalsourceid><addsrcrecordid>eNptUU1PGzEQtapWJaK5ckQr9Zzgj7Vjn1AUtYAUhITK2fLO2sF0dx3sDRL_vkMJlEqxD7Zn3nsznkfICaNzoQ0_82M_55TXc8YV1Z_IhC0MnzHK5Of9nRrNjsi0lAeKSyqmtfxKjpAtDFuoCbm-jeV3FRyMKZcqpFzFIXgYY9qVClK_7SI4fA2lcmH0udq4MmYEpP4ZoVXqWgxuEeKHsXwjX4Lrip_uz2Ny9_PHr9XlbH1zcbVarmcgFmyc-VYK74E6phuhXV1rCUoFAU3TMmW0g7rhhmPCQOOlDA1oQbWp2UIL8LU4Juevuttd0_sWsHZ2nd3m2Lv8bJOL9v_MEO_tJj1ZxjjqGIoK3_cKOT3ufBntQ9rlAZu2WKlWXEul_qE2rvMWJ5NQDfpYwC41VRJHygWi5gdQuFvfR0iDDxHjhwiQUynZh_fOGbUvzlp01r44a_86i4TTj_99h7_5KP4AjJefOw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3084628566</pqid></control><display><type>article</type><title>Risk factors for infectious complications after gastrectomy in older patients</title><source>PubMed Central</source><creator>Iida, Michihisa ; Takeda, Shigeru ; Yamamoto, Tsunenori ; Nakashima, Chiyo ; Nishiyama, Mitsuo ; Watanabe, Yusaku ; Shindo, Yoshitaro ; Tokumitsu, Yukio ; Tomochika, Shinobu ; Nakagami, Yuki ; Takahashi, Hidenori ; Nagano, Hiroaki</creator><creatorcontrib>Iida, Michihisa ; Takeda, Shigeru ; Yamamoto, Tsunenori ; Nakashima, Chiyo ; Nishiyama, Mitsuo ; Watanabe, Yusaku ; Shindo, Yoshitaro ; Tokumitsu, Yukio ; Tomochika, Shinobu ; Nakagami, Yuki ; Takahashi, Hidenori ; Nagano, Hiroaki</creatorcontrib><description>The present study aimed to identify preoperative and perioperative risk factors for postoperative infectious complications in older patients with gastric cancer. The present retrospective study included 504 patients with gastric cancer aged >65 years who underwent radical gastrectomy. After determining the cutoff values for various perioperative factors in the receiver operating characteristic curve analysis, preoperative and perioperative risk factors for the development of infectious complications after gastrectomy were examined using logistic regression analysis. Of the 504 patients who underwent gastrectomy, 95 (18.8%) developed infectious complications of grade II-V based on the Clavien-Dindo classification. In an analysis restricted to preoperative factors, male sex, low prognostic nutritional index, high visceral fat area and total gastrectomy were independent risk factors for infectious complications after gastrectomy. Among all perioperative factors, a low prognostic nutritional index and long operative duration were identified as independent risk factors for infectious complications after gastrectomy. The patients were divided into five groups according to the number of positive preoperative risk factors for infectious complications, and the incidence of infectious complications differed among the five groups (0 factors, 6.7%; 1 factor, 10.4%; 2 factors, 18.9%; 3 factors, 27.8%; and 4 factors, 47.6%; P<0.001). Older patients with gastric cancer who have a number of preoperative risk factors require careful consideration of the indication for gastrectomy and a shorter operative time to reduce infectious complications.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2024.12608</identifier><identifier>PMID: 38939176</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Abscesses ; Aged patients ; Anastomosis ; Blood ; Body mass index ; Care and treatment ; Comorbidity ; Complications and side effects ; Development and progression ; Dissection ; Fistula ; Gastrectomy ; Gastric cancer ; Gastrointestinal surgery ; Hospitals ; Lymphatic system ; Lymphocytes ; Musculoskeletal system ; Neutrophils ; Older people ; Patients ; Pneumonia ; Prevention ; Proteins ; Risk factors ; Stomach cancer ; Surgical anastomosis ; Urinary tract diseases ; Urinary tract infections ; Urogenital system ; Variables</subject><ispartof>Experimental and therapeutic medicine, 2024-08, Vol.28 (2), p.319, Article 319</ispartof><rights>Copyright: © 2024 Iida et al.</rights><rights>COPYRIGHT 2024 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2024</rights><rights>Copyright: © 2024 Iida et al. 2024</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c371t-ed53eec0a18b38a4485c66f3cbbd1698ac4b292a449cbe55fbc8308941783ce43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208990/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208990/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38939176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iida, Michihisa</creatorcontrib><creatorcontrib>Takeda, Shigeru</creatorcontrib><creatorcontrib>Yamamoto, Tsunenori</creatorcontrib><creatorcontrib>Nakashima, Chiyo</creatorcontrib><creatorcontrib>Nishiyama, Mitsuo</creatorcontrib><creatorcontrib>Watanabe, Yusaku</creatorcontrib><creatorcontrib>Shindo, Yoshitaro</creatorcontrib><creatorcontrib>Tokumitsu, Yukio</creatorcontrib><creatorcontrib>Tomochika, Shinobu</creatorcontrib><creatorcontrib>Nakagami, Yuki</creatorcontrib><creatorcontrib>Takahashi, Hidenori</creatorcontrib><creatorcontrib>Nagano, Hiroaki</creatorcontrib><title>Risk factors for infectious complications after gastrectomy in older patients</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The present study aimed to identify preoperative and perioperative risk factors for postoperative infectious complications in older patients with gastric cancer. The present retrospective study included 504 patients with gastric cancer aged >65 years who underwent radical gastrectomy. After determining the cutoff values for various perioperative factors in the receiver operating characteristic curve analysis, preoperative and perioperative risk factors for the development of infectious complications after gastrectomy were examined using logistic regression analysis. Of the 504 patients who underwent gastrectomy, 95 (18.8%) developed infectious complications of grade II-V based on the Clavien-Dindo classification. In an analysis restricted to preoperative factors, male sex, low prognostic nutritional index, high visceral fat area and total gastrectomy were independent risk factors for infectious complications after gastrectomy. Among all perioperative factors, a low prognostic nutritional index and long operative duration were identified as independent risk factors for infectious complications after gastrectomy. The patients were divided into five groups according to the number of positive preoperative risk factors for infectious complications, and the incidence of infectious complications differed among the five groups (0 factors, 6.7%; 1 factor, 10.4%; 2 factors, 18.9%; 3 factors, 27.8%; and 4 factors, 47.6%; P<0.001). Older patients with gastric cancer who have a number of preoperative risk factors require careful consideration of the indication for gastrectomy and a shorter operative time to reduce infectious complications.</description><subject>Abscesses</subject><subject>Aged patients</subject><subject>Anastomosis</subject><subject>Blood</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Dissection</subject><subject>Fistula</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Gastrointestinal surgery</subject><subject>Hospitals</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Musculoskeletal system</subject><subject>Neutrophils</subject><subject>Older people</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Prevention</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>Stomach cancer</subject><subject>Surgical anastomosis</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urogenital system</subject><subject>Variables</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptUU1PGzEQtapWJaK5ckQr9Zzgj7Vjn1AUtYAUhITK2fLO2sF0dx3sDRL_vkMJlEqxD7Zn3nsznkfICaNzoQ0_82M_55TXc8YV1Z_IhC0MnzHK5Of9nRrNjsi0lAeKSyqmtfxKjpAtDFuoCbm-jeV3FRyMKZcqpFzFIXgYY9qVClK_7SI4fA2lcmH0udq4MmYEpP4ZoVXqWgxuEeKHsXwjX4Lrip_uz2Ny9_PHr9XlbH1zcbVarmcgFmyc-VYK74E6phuhXV1rCUoFAU3TMmW0g7rhhmPCQOOlDA1oQbWp2UIL8LU4Juevuttd0_sWsHZ2nd3m2Lv8bJOL9v_MEO_tJj1ZxjjqGIoK3_cKOT3ufBntQ9rlAZu2WKlWXEul_qE2rvMWJ5NQDfpYwC41VRJHygWi5gdQuFvfR0iDDxHjhwiQUynZh_fOGbUvzlp01r44a_86i4TTj_99h7_5KP4AjJefOw</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Iida, Michihisa</creator><creator>Takeda, Shigeru</creator><creator>Yamamoto, Tsunenori</creator><creator>Nakashima, Chiyo</creator><creator>Nishiyama, Mitsuo</creator><creator>Watanabe, Yusaku</creator><creator>Shindo, Yoshitaro</creator><creator>Tokumitsu, Yukio</creator><creator>Tomochika, Shinobu</creator><creator>Nakagami, Yuki</creator><creator>Takahashi, Hidenori</creator><creator>Nagano, Hiroaki</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-ed53eec0a18b38a4485c66f3cbbd1698ac4b292a449cbe55fbc8308941783ce43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abscesses</topic><topic>Aged patients</topic><topic>Anastomosis</topic><topic>Blood</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Comorbidity</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Dissection</topic><topic>Fistula</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Gastrointestinal surgery</topic><topic>Hospitals</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Musculoskeletal system</topic><topic>Neutrophils</topic><topic>Older people</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Prevention</topic><topic>Proteins</topic><topic>Risk 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The present retrospective study included 504 patients with gastric cancer aged >65 years who underwent radical gastrectomy. After determining the cutoff values for various perioperative factors in the receiver operating characteristic curve analysis, preoperative and perioperative risk factors for the development of infectious complications after gastrectomy were examined using logistic regression analysis. Of the 504 patients who underwent gastrectomy, 95 (18.8%) developed infectious complications of grade II-V based on the Clavien-Dindo classification. In an analysis restricted to preoperative factors, male sex, low prognostic nutritional index, high visceral fat area and total gastrectomy were independent risk factors for infectious complications after gastrectomy. Among all perioperative factors, a low prognostic nutritional index and long operative duration were identified as independent risk factors for infectious complications after gastrectomy. The patients were divided into five groups according to the number of positive preoperative risk factors for infectious complications, and the incidence of infectious complications differed among the five groups (0 factors, 6.7%; 1 factor, 10.4%; 2 factors, 18.9%; 3 factors, 27.8%; and 4 factors, 47.6%; P<0.001). Older patients with gastric cancer who have a number of preoperative risk factors require careful consideration of the indication for gastrectomy and a shorter operative time to reduce infectious complications.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>38939176</pmid><doi>10.3892/etm.2024.12608</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Abscesses Aged patients Anastomosis Blood Body mass index Care and treatment Comorbidity Complications and side effects Development and progression Dissection Fistula Gastrectomy Gastric cancer Gastrointestinal surgery Hospitals Lymphatic system Lymphocytes Musculoskeletal system Neutrophils Older people Patients Pneumonia Prevention Proteins Risk factors Stomach cancer Surgical anastomosis Urinary tract diseases Urinary tract infections Urogenital system Variables |
| title | Risk factors for infectious complications after gastrectomy in older patients |
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