Structural mechanism of bridge RNA-guided recombination

Insertion sequence (IS) elements are the simplest autonomous transposable elements found in prokaryotic genomes 1 . We recently discovered that IS110 family elements encode a recombinase and a non-coding bridge RNA (bRNA) that confers modular specificity for target DNA and donor DNA through two prog...

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Veröffentlicht in:	Nature (London) 2024-06, Vol.630 (8018), p.994-1002
Hauptverfasser:	Hiraizumi, Masahiro, Perry, Nicholas T., Durrant, Matthew G., Soma, Teppei, Nagahata, Naoto, Okazaki, Sae, Athukoralage, Januka S., Isayama, Yukari, Pai, James J., Pawluk, April, Konermann, Silvana, Yamashita, Keitaro, Hsu, Patrick D., Nishimasu, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/337/149 631/337/2569 631/45/173 631/535 Binding Catalytic Domain Cryoelectron Microscopy Deoxyribonucleic acid Dimers DNA DNA - chemistry DNA - metabolism DNA - ultrastructure DNA Transposable Elements - genetics Electron microscopy Genomes Humanities and Social Sciences Intermediates Microscopy Models, Molecular multidisciplinary Nucleic Acid Conformation Nucleotide sequence Phosphoserine Protein Multimerization Recombinase Recombinases - chemistry Recombinases - genetics Recombinases - metabolism Recombination Recombination reactions Recombination, Genetic Ribonucleic acid RNA RNA, Untranslated - chemistry RNA, Untranslated - genetics RNA, Untranslated - metabolism RNA, Untranslated - ultrastructure Science Science (multidisciplinary) Strands Substrate Specificity
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