Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair
Appropriate biodegradability to meet the demands of wound repair is critical for superficial wound repair membrane applications. Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes...
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| Veröffentlicht in: | Materials 2024-06, Vol.17 (12), p.2839 |
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| creator | Liu, Yu Liu, Xuping Jiao, Yuhong Li, Mingzhong |
| description | Appropriate biodegradability to meet the demands of wound repair is critical for superficial wound repair membrane applications. Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes could be adjusted by reaction ratios of tyrosinase against SF (TYR/SF). Upon reaching a TYR/SF ratio of 20/6000, the degree of crosslinking increased to 88.17 ± 0.20%, without obvious changes in the crystal structure. The degradation behavior was regulated by the TYR/SF ratio and the degradation environment. All c-SF membranes remained stable after immersion without collagenase but showed an adjustable degradation behavior in the presence of collagenase. As the TYR/SF ratio increased, the residual weights increased from 23.31 ± 1.35% to 60.12 ± 0.82% after 7 days of degradation, occurring with low increased amounts of β-sheet structure and free amino acids. This work provides a new c-SF membrane with controllable rapid degradability and favorable cytocompatibility, which can help to meet requirements for biodegradable superficial wound repair membranes. |
| doi_str_mv | 10.3390/ma17122839 |
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Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes could be adjusted by reaction ratios of tyrosinase against SF (TYR/SF). Upon reaching a TYR/SF ratio of 20/6000, the degree of crosslinking increased to 88.17 ± 0.20%, without obvious changes in the crystal structure. The degradation behavior was regulated by the TYR/SF ratio and the degradation environment. All c-SF membranes remained stable after immersion without collagenase but showed an adjustable degradation behavior in the presence of collagenase. As the TYR/SF ratio increased, the residual weights increased from 23.31 ± 1.35% to 60.12 ± 0.82% after 7 days of degradation, occurring with low increased amounts of β-sheet structure and free amino acids. This work provides a new c-SF membrane with controllable rapid degradability and favorable cytocompatibility, which can help to meet requirements for biodegradable superficial wound repair membranes.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma17122839</identifier><identifier>PMID: 38930208</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Analysis ; Biocompatibility ; Biomedical materials ; Care and treatment ; Controllability ; Crosslinked polymers ; Crosslinking ; Crystal structure ; Crystals ; Degradation ; Electronics industry ; Fourier transforms ; Mechanical properties ; Membranes ; Physical properties ; Ratios ; Regenerative medicine ; Silk ; Structure ; Tissue engineering ; Tyrosinase ; Wounds and injuries</subject><ispartof>Materials, 2024-06, Vol.17 (12), p.2839</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c363t-1bc9fe970151f90dfbce4b3ed0e86ed47c545873edc54390e7df809758c2eef53</cites><orcidid>0000-0002-3353-9868 ; 0000-0002-8025-1488</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38930208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Liu, Xuping</creatorcontrib><creatorcontrib>Jiao, Yuhong</creatorcontrib><creatorcontrib>Li, Mingzhong</creatorcontrib><title>Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair</title><title>Materials</title><addtitle>Materials (Basel)</addtitle><description>Appropriate biodegradability to meet the demands of wound repair is critical for superficial wound repair membrane applications. Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes could be adjusted by reaction ratios of tyrosinase against SF (TYR/SF). Upon reaching a TYR/SF ratio of 20/6000, the degree of crosslinking increased to 88.17 ± 0.20%, without obvious changes in the crystal structure. The degradation behavior was regulated by the TYR/SF ratio and the degradation environment. All c-SF membranes remained stable after immersion without collagenase but showed an adjustable degradation behavior in the presence of collagenase. As the TYR/SF ratio increased, the residual weights increased from 23.31 ± 1.35% to 60.12 ± 0.82% after 7 days of degradation, occurring with low increased amounts of β-sheet structure and free amino acids. This work provides a new c-SF membrane with controllable rapid degradability and favorable cytocompatibility, which can help to meet requirements for biodegradable superficial wound repair membranes.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Care and treatment</subject><subject>Controllability</subject><subject>Crosslinked polymers</subject><subject>Crosslinking</subject><subject>Crystal structure</subject><subject>Crystals</subject><subject>Degradation</subject><subject>Electronics industry</subject><subject>Fourier transforms</subject><subject>Mechanical properties</subject><subject>Membranes</subject><subject>Physical properties</subject><subject>Ratios</subject><subject>Regenerative medicine</subject><subject>Silk</subject><subject>Structure</subject><subject>Tissue engineering</subject><subject>Tyrosinase</subject><subject>Wounds and injuries</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk1v1DAQtRCIVksv_AAUiQtCSrHjJLZPqFooIBWB2iKOluOMU7eOvbUTpO2vx2FLPxD2waM3b954PhB6SfAhpQK_GxVhpKo4FU_QPhGiLYmo66cP7D10kNIlzodSwivxHO1RLiiuMN9H21MYZqcmG3wRTDFdQPEBhqj6HfQ9hg3EyUJavOfbGJL1KkG5VpNy2xvoi3XGkrP-yvqhOLPuqvgKYxeVzzEmxOJszgrGaqtc8TPMvi9OYaNsfIGeGeUSHNy-K_Tj-OP5-nN58u3Tl_XRSalpS6eSdFoYEAyThhiBe9NpqDsKPQbeQl8z3dQNZxnIRm4IsN5wLFjDdQVgGrpC73e6m7kbMwv8FJWTm2hHFbcyKCsfe7y9kEP4JQmpcN22bVZ4c6sQw_UMaZKjTRqcyzWGOUmKWcUxb3KDV-j1P9TLMEef6_vDajimuL5nDcqBtN6EnFgvovKI5bFVjLTLxw__w8q3h9Hq4MHYjD8KeLsL0MtIIpi7IgmWy7LI-2XJ5FcP23JH_bsa9Dfu8rrP</recordid><startdate>20240611</startdate><enddate>20240611</enddate><creator>Liu, Yu</creator><creator>Liu, Xuping</creator><creator>Jiao, Yuhong</creator><creator>Li, Mingzhong</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3353-9868</orcidid><orcidid>https://orcid.org/0000-0002-8025-1488</orcidid></search><sort><creationdate>20240611</creationdate><title>Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair</title><author>Liu, Yu ; Liu, Xuping ; Jiao, Yuhong ; Li, Mingzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-1bc9fe970151f90dfbce4b3ed0e86ed47c545873edc54390e7df809758c2eef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amino acids</topic><topic>Analysis</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Care and treatment</topic><topic>Controllability</topic><topic>Crosslinked polymers</topic><topic>Crosslinking</topic><topic>Crystal structure</topic><topic>Crystals</topic><topic>Degradation</topic><topic>Electronics industry</topic><topic>Fourier transforms</topic><topic>Mechanical properties</topic><topic>Membranes</topic><topic>Physical properties</topic><topic>Ratios</topic><topic>Regenerative medicine</topic><topic>Silk</topic><topic>Structure</topic><topic>Tissue engineering</topic><topic>Tyrosinase</topic><topic>Wounds and injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Liu, Xuping</creatorcontrib><creatorcontrib>Jiao, Yuhong</creatorcontrib><creatorcontrib>Li, Mingzhong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yu</au><au>Liu, Xuping</au><au>Jiao, Yuhong</au><au>Li, Mingzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair</atitle><jtitle>Materials</jtitle><addtitle>Materials (Basel)</addtitle><date>2024-06-11</date><risdate>2024</risdate><volume>17</volume><issue>12</issue><spage>2839</spage><pages>2839-</pages><issn>1996-1944</issn><eissn>1996-1944</eissn><abstract>Appropriate biodegradability to meet the demands of wound repair is critical for superficial wound repair membrane applications. Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes could be adjusted by reaction ratios of tyrosinase against SF (TYR/SF). Upon reaching a TYR/SF ratio of 20/6000, the degree of crosslinking increased to 88.17 ± 0.20%, without obvious changes in the crystal structure. The degradation behavior was regulated by the TYR/SF ratio and the degradation environment. All c-SF membranes remained stable after immersion without collagenase but showed an adjustable degradation behavior in the presence of collagenase. As the TYR/SF ratio increased, the residual weights increased from 23.31 ± 1.35% to 60.12 ± 0.82% after 7 days of degradation, occurring with low increased amounts of β-sheet structure and free amino acids. 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amino acids Analysis Biocompatibility Biomedical materials Care and treatment Controllability Crosslinked polymers Crosslinking Crystal structure Crystals Degradation Electronics industry Fourier transforms Mechanical properties Membranes Physical properties Ratios Regenerative medicine Silk Structure Tissue engineering Tyrosinase Wounds and injuries |
| title | Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair |
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