Metabolomics Reveals Tyrosine Kinase Inhibitor Resistance-Associated Metabolic Events in Human Metastatic Renal Cancer Cells

The development of resistance to tyrosine kinase inhibitors (TKIs) is a major cause of treatment failure in metastatic renal cell carcinoma (mRCC). A deeper understanding of the metabolic mechanisms associated with TKI resistance is critical for refining therapeutic strategies. In this study, we est...

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Veröffentlicht in:	International journal of molecular sciences 2024-06, Vol.25 (12), p.6328
Hauptverfasser:	Amaro, Filipa, Carvalho, Márcia, Bastos, Maria de Lourdes, Guedes de Pinho, Paula, Pinto, Joana
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Cancer Cancer therapies Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell death Cell Line, Tumor Cell Proliferation - drug effects Cells Development and progression Drug Resistance, Neoplasm - drug effects Drug therapy Growth factors Health aspects Humans Hypoxia Indazoles - pharmacology Information management Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Lipids Medical prognosis Metabolism Metabolites Metabolome - drug effects Metabolomics - methods Metastasis Niacinamide NMR Nuclear magnetic resonance Pazopanib Phenols Physiological aspects Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Spectrum analysis Sulfonamides - pharmacology Sunitinib - pharmacology Triglycerides Tyrosine Tyrosine Kinase Inhibitors
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