Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K + Efflux Induced by PLO via Signal Point Mutations

is an important opportunistic pathogenic bacterium widely distributed in the environment. Pyolysin (PLO) is a primary virulence factor of and capable of lysing many different cells. PLO is a member of the cholesterol-dependent cytolysin (CDC) family of which the primary structure only presents a low...

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Veröffentlicht in:	International journal of molecular sciences 2024-06, Vol.25 (12), p.6703
Hauptverfasser:	Shan, Qiang, Ma, Wenbo, Li, Bolin, Li, Qian, Wang, Xue, Li, Yanan, Wang, Jiufeng, Zhu, Yaohong, Liu, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Toxins - genetics Bacterial Toxins - metabolism Gene mutations Genes Genetic aspects Hemolysin Proteins - genetics Hemolysin Proteins - metabolism Humans Inflammasomes - metabolism Inflammation - genetics Inflammation - metabolism Inflammatory diseases Mice Mutation NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Point Mutation Potassium Potassium - metabolism Proteins Signal Transduction Toxins Virulence
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