Emerging mechanistic understanding of cilia function in cellular signalling

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a re...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2024-07, Vol.25 (7), p.555-573
Hauptverfasser:	Hilgendorf, Keren I., Myers, Benjamin R., Reiter, Jeremy F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2432 631/80/86 631/80/86/2370 Animals Biochemistry Biomedical and Life Sciences Birth defects Cancer Research Cell Biology Cell Communication Cell interactions Cilia Cilia - metabolism Cilia - physiology Ciliopathies - genetics Ciliopathies - metabolism Ciliopathies - pathology Congenital defects Developmental Biology G protein-coupled receptors Hedgehog protein Hedgehog Proteins - metabolism Homeostasis Hubs Humans Ion channels Kidney diseases Life Sciences Lipids Metabolic disorders Metabolic syndrome Organelles Polycystic kidney Proteins Receptor mechanisms Receptors, G-Protein-Coupled - metabolism Review Article Reviews Sensory integration Signal Transduction Stem Cells TRPP Cation Channels - metabolism
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