Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a re...
Gespeichert in:
| Veröffentlicht in: | Nature reviews. Molecular cell biology 2024-07, Vol.25 (7), p.555-573 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 573 |
|---|---|
| container_issue | 7 |
| container_start_page | 555 |
| container_title | Nature reviews. Molecular cell biology |
| container_volume | 25 |
| creator | Hilgendorf, Keren I. Myers, Benjamin R. Reiter, Jeremy F. |
| description | Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell–cell communication using three signalling pathways as examples: ciliary G-protein-coupled receptors (GPCRs), the Hedgehog (Hh) pathway and polycystin ion channels. We review how defects in these ciliary signalling pathways lead to a heterogeneous group of conditions known as ‘ciliopathies’, including metabolic syndromes, birth defects and polycystic kidney disease. Emerging understanding of these pathways’ transduction mechanisms reveals common themes between these cilia-based signalling pathways that may apply to other pathways as well. These mechanistic insights reveal how cilia orchestrate normal and pathophysiological signalling outputs broadly throughout human biology.
Cilia are microtubule-based cell projections that provide a unique environment with precise protein, lipid and second messenger concentrations, thereby creating specialized signalling hubs. This Review discusses recent multidisciplinary, mechanistic insights into cilia-based signalling pathways during development and homeostasis. |
| doi_str_mv | 10.1038/s41580-023-00698-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11199107</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3072089718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-673111e3afb52d3a260c46798450a4620cfd8538380f86ca6eeea674df680ff43</originalsourceid><addsrcrecordid>eNp9UctOxSAUJEbj-wdcmCZu3FQPjwJdGXPjK5q40TVBChXTUoXWxL-X69XrY-EKOGfOnBkGoT0MRxioPE4MVxJKILQE4LUsqxW0iZnA-SlhdXkXZANtpfQEgDkW1TraoJJyDlRsouuz3sbWh7borXnUwafRm2IKjY1p1KGZdwZXGN95XbgpmNEPofChMLbrpk7HIvk26K7LwB205nSX7O7nuY3uz8_uZpflze3F1ez0pjSM4rHkgmKMLdXuoSIN1YSDYVzUklWgGSdgXCOrLFGCk9xobq3VXLDG8VxxjG6jkwXv8_TQ28bYMEbdqefoex3f1KC9-t0J_lG1w6vKa-sag8gMh58McXiZbBpV79PckQ52mJIiNZGEZQnzZQd_oE_DFLPjpGj-WZC1wDKjyAJl4pBStG6pBoOah6UWYakclvoIS1V5aP-nj-XIVzoZQBeAlFuhtfF79z-075kMoB4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3072089718</pqid></control><display><type>article</type><title>Emerging mechanistic understanding of cilia function in cellular signalling</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><creator>Hilgendorf, Keren I. ; Myers, Benjamin R. ; Reiter, Jeremy F.</creator><creatorcontrib>Hilgendorf, Keren I. ; Myers, Benjamin R. ; Reiter, Jeremy F.</creatorcontrib><description>Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell–cell communication using three signalling pathways as examples: ciliary G-protein-coupled receptors (GPCRs), the Hedgehog (Hh) pathway and polycystin ion channels. We review how defects in these ciliary signalling pathways lead to a heterogeneous group of conditions known as ‘ciliopathies’, including metabolic syndromes, birth defects and polycystic kidney disease. Emerging understanding of these pathways’ transduction mechanisms reveals common themes between these cilia-based signalling pathways that may apply to other pathways as well. These mechanistic insights reveal how cilia orchestrate normal and pathophysiological signalling outputs broadly throughout human biology.
Cilia are microtubule-based cell projections that provide a unique environment with precise protein, lipid and second messenger concentrations, thereby creating specialized signalling hubs. This Review discusses recent multidisciplinary, mechanistic insights into cilia-based signalling pathways during development and homeostasis.</description><identifier>ISSN: 1471-0072</identifier><identifier>ISSN: 1471-0080</identifier><identifier>EISSN: 1471-0080</identifier><identifier>DOI: 10.1038/s41580-023-00698-5</identifier><identifier>PMID: 38366037</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/2432 ; 631/80/86 ; 631/80/86/2370 ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Birth defects ; Cancer Research ; Cell Biology ; Cell Communication ; Cell interactions ; Cilia ; Cilia - metabolism ; Cilia - physiology ; Ciliopathies - genetics ; Ciliopathies - metabolism ; Ciliopathies - pathology ; Congenital defects ; Developmental Biology ; G protein-coupled receptors ; Hedgehog protein ; Hedgehog Proteins - metabolism ; Homeostasis ; Hubs ; Humans ; Ion channels ; Kidney diseases ; Life Sciences ; Lipids ; Metabolic disorders ; Metabolic syndrome ; Organelles ; Polycystic kidney ; Proteins ; Receptor mechanisms ; Receptors, G-Protein-Coupled - metabolism ; Review Article ; Reviews ; Sensory integration ; Signal Transduction ; Stem Cells ; TRPP Cation Channels - metabolism</subject><ispartof>Nature reviews. Molecular cell biology, 2024-07, Vol.25 (7), p.555-573</ispartof><rights>Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-673111e3afb52d3a260c46798450a4620cfd8538380f86ca6eeea674df680ff43</citedby><cites>FETCH-LOGICAL-c431t-673111e3afb52d3a260c46798450a4620cfd8538380f86ca6eeea674df680ff43</cites><orcidid>0000-0003-0975-539X ; 0000-0001-8377-8384</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41580-023-00698-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41580-023-00698-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38366037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hilgendorf, Keren I.</creatorcontrib><creatorcontrib>Myers, Benjamin R.</creatorcontrib><creatorcontrib>Reiter, Jeremy F.</creatorcontrib><title>Emerging mechanistic understanding of cilia function in cellular signalling</title><title>Nature reviews. Molecular cell biology</title><addtitle>Nat Rev Mol Cell Biol</addtitle><addtitle>Nat Rev Mol Cell Biol</addtitle><description>Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell–cell communication using three signalling pathways as examples: ciliary G-protein-coupled receptors (GPCRs), the Hedgehog (Hh) pathway and polycystin ion channels. We review how defects in these ciliary signalling pathways lead to a heterogeneous group of conditions known as ‘ciliopathies’, including metabolic syndromes, birth defects and polycystic kidney disease. Emerging understanding of these pathways’ transduction mechanisms reveals common themes between these cilia-based signalling pathways that may apply to other pathways as well. These mechanistic insights reveal how cilia orchestrate normal and pathophysiological signalling outputs broadly throughout human biology.
Cilia are microtubule-based cell projections that provide a unique environment with precise protein, lipid and second messenger concentrations, thereby creating specialized signalling hubs. This Review discusses recent multidisciplinary, mechanistic insights into cilia-based signalling pathways during development and homeostasis.</description><subject>631/136/2432</subject><subject>631/80/86</subject><subject>631/80/86/2370</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Birth defects</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cell Communication</subject><subject>Cell interactions</subject><subject>Cilia</subject><subject>Cilia - metabolism</subject><subject>Cilia - physiology</subject><subject>Ciliopathies - genetics</subject><subject>Ciliopathies - metabolism</subject><subject>Ciliopathies - pathology</subject><subject>Congenital defects</subject><subject>Developmental Biology</subject><subject>G protein-coupled receptors</subject><subject>Hedgehog protein</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Homeostasis</subject><subject>Hubs</subject><subject>Humans</subject><subject>Ion channels</subject><subject>Kidney diseases</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Organelles</subject><subject>Polycystic kidney</subject><subject>Proteins</subject><subject>Receptor mechanisms</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Review Article</subject><subject>Reviews</subject><subject>Sensory integration</subject><subject>Signal Transduction</subject><subject>Stem Cells</subject><subject>TRPP Cation Channels - metabolism</subject><issn>1471-0072</issn><issn>1471-0080</issn><issn>1471-0080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOxSAUJEbj-wdcmCZu3FQPjwJdGXPjK5q40TVBChXTUoXWxL-X69XrY-EKOGfOnBkGoT0MRxioPE4MVxJKILQE4LUsqxW0iZnA-SlhdXkXZANtpfQEgDkW1TraoJJyDlRsouuz3sbWh7borXnUwafRm2IKjY1p1KGZdwZXGN95XbgpmNEPofChMLbrpk7HIvk26K7LwB205nSX7O7nuY3uz8_uZpflze3F1ez0pjSM4rHkgmKMLdXuoSIN1YSDYVzUklWgGSdgXCOrLFGCk9xobq3VXLDG8VxxjG6jkwXv8_TQ28bYMEbdqefoex3f1KC9-t0J_lG1w6vKa-sag8gMh58McXiZbBpV79PckQ52mJIiNZGEZQnzZQd_oE_DFLPjpGj-WZC1wDKjyAJl4pBStG6pBoOah6UWYakclvoIS1V5aP-nj-XIVzoZQBeAlFuhtfF79z-075kMoB4</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Hilgendorf, Keren I.</creator><creator>Myers, Benjamin R.</creator><creator>Reiter, Jeremy F.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0975-539X</orcidid><orcidid>https://orcid.org/0000-0001-8377-8384</orcidid></search><sort><creationdate>202407</creationdate><title>Emerging mechanistic understanding of cilia function in cellular signalling</title><author>Hilgendorf, Keren I. ; Myers, Benjamin R. ; Reiter, Jeremy F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-673111e3afb52d3a260c46798450a4620cfd8538380f86ca6eeea674df680ff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>631/136/2432</topic><topic>631/80/86</topic><topic>631/80/86/2370</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Birth defects</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Cell Communication</topic><topic>Cell interactions</topic><topic>Cilia</topic><topic>Cilia - metabolism</topic><topic>Cilia - physiology</topic><topic>Ciliopathies - genetics</topic><topic>Ciliopathies - metabolism</topic><topic>Ciliopathies - pathology</topic><topic>Congenital defects</topic><topic>Developmental Biology</topic><topic>G protein-coupled receptors</topic><topic>Hedgehog protein</topic><topic>Hedgehog Proteins - metabolism</topic><topic>Homeostasis</topic><topic>Hubs</topic><topic>Humans</topic><topic>Ion channels</topic><topic>Kidney diseases</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Organelles</topic><topic>Polycystic kidney</topic><topic>Proteins</topic><topic>Receptor mechanisms</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Review Article</topic><topic>Reviews</topic><topic>Sensory integration</topic><topic>Signal Transduction</topic><topic>Stem Cells</topic><topic>TRPP Cation Channels - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilgendorf, Keren I.</creatorcontrib><creatorcontrib>Myers, Benjamin R.</creatorcontrib><creatorcontrib>Reiter, Jeremy F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Molecular cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilgendorf, Keren I.</au><au>Myers, Benjamin R.</au><au>Reiter, Jeremy F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging mechanistic understanding of cilia function in cellular signalling</atitle><jtitle>Nature reviews. Molecular cell biology</jtitle><stitle>Nat Rev Mol Cell Biol</stitle><addtitle>Nat Rev Mol Cell Biol</addtitle><date>2024-07</date><risdate>2024</risdate><volume>25</volume><issue>7</issue><spage>555</spage><epage>573</epage><pages>555-573</pages><issn>1471-0072</issn><issn>1471-0080</issn><eissn>1471-0080</eissn><abstract>Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell–cell communication using three signalling pathways as examples: ciliary G-protein-coupled receptors (GPCRs), the Hedgehog (Hh) pathway and polycystin ion channels. We review how defects in these ciliary signalling pathways lead to a heterogeneous group of conditions known as ‘ciliopathies’, including metabolic syndromes, birth defects and polycystic kidney disease. Emerging understanding of these pathways’ transduction mechanisms reveals common themes between these cilia-based signalling pathways that may apply to other pathways as well. These mechanistic insights reveal how cilia orchestrate normal and pathophysiological signalling outputs broadly throughout human biology.
Cilia are microtubule-based cell projections that provide a unique environment with precise protein, lipid and second messenger concentrations, thereby creating specialized signalling hubs. This Review discusses recent multidisciplinary, mechanistic insights into cilia-based signalling pathways during development and homeostasis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38366037</pmid><doi>10.1038/s41580-023-00698-5</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0003-0975-539X</orcidid><orcidid>https://orcid.org/0000-0001-8377-8384</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-0072 |
| ispartof | Nature reviews. Molecular cell biology, 2024-07, Vol.25 (7), p.555-573 |
| issn | 1471-0072 1471-0080 1471-0080 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11199107 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | 631/136/2432 631/80/86 631/80/86/2370 Animals Biochemistry Biomedical and Life Sciences Birth defects Cancer Research Cell Biology Cell Communication Cell interactions Cilia Cilia - metabolism Cilia - physiology Ciliopathies - genetics Ciliopathies - metabolism Ciliopathies - pathology Congenital defects Developmental Biology G protein-coupled receptors Hedgehog protein Hedgehog Proteins - metabolism Homeostasis Hubs Humans Ion channels Kidney diseases Life Sciences Lipids Metabolic disorders Metabolic syndrome Organelles Polycystic kidney Proteins Receptor mechanisms Receptors, G-Protein-Coupled - metabolism Review Article Reviews Sensory integration Signal Transduction Stem Cells TRPP Cation Channels - metabolism |
| title | Emerging mechanistic understanding of cilia function in cellular signalling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T15%3A28%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Emerging%20mechanistic%20understanding%20of%20cilia%20function%20in%20cellular%20signalling&rft.jtitle=Nature%20reviews.%20Molecular%20cell%20biology&rft.au=Hilgendorf,%20Keren%20I.&rft.date=2024-07&rft.volume=25&rft.issue=7&rft.spage=555&rft.epage=573&rft.pages=555-573&rft.issn=1471-0072&rft.eissn=1471-0080&rft_id=info:doi/10.1038/s41580-023-00698-5&rft_dat=%3Cproquest_pubme%3E3072089718%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3072089718&rft_id=info:pmid/38366037&rfr_iscdi=true |