THE EFFECT OF PARICALCITOL AND CALCITRIOL WITH OR WITHOUT CALCIMIMETICS ON PULSE WAVE VELOCITY AND SERUM LEVELS FOR PARATHYROID HORMONE, CALCIUM AND PHOSPHORUS IN MAINTENANCE HEMODIALYSIS PATIENTS
Different vitamin D analogs might have advantages over calcitriol. To evaluate the effects of paricalcitol . calcitriol based vitamin D receptor activators on calcium-phosphate metabolism and pulse wave velocity in hemodialysis patients. Observational, cross-sectional and 1 year follow-up study. 181...
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Veröffentlicht in: | Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2023-10, Vol.19 (4), p.480-486 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Different vitamin D analogs might have advantages over calcitriol.
To evaluate the effects of paricalcitol
. calcitriol based vitamin D receptor activators on calcium-phosphate metabolism and pulse wave velocity in hemodialysis patients.
Observational, cross-sectional and 1 year follow-up study.
181 hemodialysis patients were enrolled in this study as divided in to 5 groups based on vitamin D therapy. Baseline and 12
month data on blood biochemistry, pulse wave velocity and cumulative dose of treatments were compared in each study group as well as in overall paricalcitol
. calcitriol-based treatment groups.
From baseline to 12
month, significant improvement in pulse wave velocity and parathyroid hormone was shown in paricalcitol-based treatment group without a significant change in calcium, phosphate, alkaline phosphatase. A significant increase in pulse wave velocity, serum phosphate levels, calcium x phosphate product and serum alkaline phosphatase levels were noted in calcitriol-based treatment group with no significant change in serum calcium and parathyroid hormone levels.
Our findings revealed superiority of paricalcitol than calcitriol based vitamin D receptor activator therapy in terms of serum phosphate levels, CaxP product, dose requirement for vitamin D and the control of pulse wave velocity. |
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ISSN: | 1841-0987 1843-066X |
DOI: | 10.4183/aeb.2023.480 |