β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression

To explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), and to investigate the underlying mechanism using network pharmacology. Human hepatocellular carcinoma cell lines (Huh-7 and HCCLM3) w...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2024-07, Vol.37 (4), p.1156-1169
Hauptverfasser:	Wang, Ruoyu, Tang, Dan, Ou, Longyun, Jiang, Jiacheng, Wu, Yu-nan, Tian, Xuefei
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - genetics BAX protein Bcl-2 protein Biomedical and Life Sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Movement - genetics Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Cell Survival - drug effects Cell Survival - genetics Cell viability Cholecystokinin E-cadherin Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Flow cytometry G1 phase Gene Expression - drug effects Gene Expression - genetics Gene Expression Regulation, Neoplastic - drug effects Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Gynecology Hepatocellular carcinoma Humans Kinases Life Sciences Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis N-Cadherin Neoplasm Invasiveness - genetics Network Pharmacology Oncology Phenotype Phenotypes Reproductive Medicine Research Article Sitosterols - pharmacology Stem Cells Surgery Therapeutic targets Tumor cell lines Vimentin
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