VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor in East Asia. Hypoxia, a hallmark of solid tumors, significantly alters redox homeostasis inside tumor microenvironment. This alteration drives tumor proliferation, invasion, and metastasis, leading to poor prognostic outcomes. Ho...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2024, Vol.37 (4), p.1141-1155
Hauptverfasser:	Miao, Huikai, Gao, Wuyou, Zhong, Leqi, Li, Hongmu, Chen, Dongni, Xu, Chunmei, Wen, Zhesheng, Chen, Youfang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy Biomedical and Life Sciences Cell Biology Cell Line, Tumor Cell Proliferation - genetics Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - pathology Esophagus Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics Genes Gynecology Homeostasis Humans Hypoxia Hypoxia - genetics Immunohistochemistry Life Sciences Metastases Oncology Prognosis Reproductive Medicine Research Article Solid tumors Squamous cell carcinoma Stem Cells Surgery Transcriptome - genetics Transcriptomes Tumor Hypoxia - genetics Tumor microenvironment
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