Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status
Background Human epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits of antibody–drug conjugates (ADCs) in breast cancer patients. We aimed to investigate the concordance of HER2 status between core needle biopsy (CNB) and...
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| Veröffentlicht in: | Breast cancer (Tokyo, Japan) Japan), 2024-07, Vol.31 (4), p.705-716 |
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| container_title | Breast cancer (Tokyo, Japan) |
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| creator | Na, Sei Kim, Milim Park, Yujun Kwon, Hyun Jung Shin, Hee-Chul Kim, Eun-Kyu Jang, Mijung Kim, Sun Mi Park, So Yeon |
| description | Background
Human epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits of antibody–drug conjugates (ADCs) in breast cancer patients. We aimed to investigate the concordance of HER2 status between core needle biopsy (CNB) and subsequent surgical resection specimens focusing on the HER2-low status.
Methods
This retrospective study was conducted in 1,387 patients with invasive breast cancer whose HER2 status was evaluated in both CNB and surgical resection specimens. The discordance rates between CNB and surgical resection specimens and the clinicopathological features associated with HER2 status discordance were analyzed.
Results
The overall concordance rates of HER2 status between CNB and surgical resection specimens were 99.0% (
κ
= 0.925) for two-group classification (negative vs. positive) and 78.5% (
κ
= 0.587) for three-group classification (zero vs. low vs. positive). The largest discordance occurred in CNB-HER2-zero cases with 42.8% of them reclassified as HER2-low in surgical resection. HER2 discordance was associated with lower histologic grade, tumor multiplicity, and luminal A subtype. In multivariate analysis, tumor multiplicity and estrogen receptor (ER) positivity were independent predictive factors for HER2-zero to low conversion.
Conclusions
Incorporation of HER2-low category in HER2 status interpretation reduces the concordance rate between CNB and surgical resection specimens. Tumor multiplicity and ER positivity are predictive factors for conversion from HER2-zero to HER2-low status. Therefore, HER2 status should be re-evaluated in resection specimens when considering ADCs in tumors exhibiting multiplicity and ER positivity. |
| doi_str_mv | 10.1007/s12282-024-01585-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11194196</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3043072871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-9a3ab76f0756838dcf7c93447dbc01c54d9ac14726b58423e19f0a882b3ddef03</originalsourceid><addsrcrecordid>eNp9UdtqFDEYDqLYWn0BLySX3ozmNJOMNyJLD0JBkPY6ZDL_bFNmkzV_xrLv4QOb7a5Fb4RAAt8pfB8hbzn7wBnTH5ELYUTDhGoYb03byGfklBvDGiWkfF7fUrGmM505Ia8Q7xlTUrPuJTmRplNSif6U_Fql6FMeXfRA00Svzr8LisWVBekA5QEg0ooDjQDjDHQIaYs76uJIccnr4N1MMyD4ElKkuAUfNhBxbzVkcFio31vnT1VSj5t3GJBOyS8Y4ppWTbmDx9RmTg_H5NfkxeRmhDfH-4zcXpzfrK6a62-XX1dfrhsve1Oa3kk36G5iuu2MNKOftO-lUnocPOO-VWPvPFdadENraiXA-4k5Y8QgxxEmJs_I54Pvdhk2MHqIJbvZbnPYuLyzyQX7LxLDnV2nn5Zz3ived9Xh_dEhpx8LYLGbgB7m2UVIC1pZK2daGM0rVRyoPifEDNNTDmd2v6c97GnrnvZxTyur6N3fP3yS_BmwEuSBgBWKa8j2Pi259oz_s_0NAbyucg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3043072871</pqid></control><display><type>article</type><title>Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Na, Sei ; Kim, Milim ; Park, Yujun ; Kwon, Hyun Jung ; Shin, Hee-Chul ; Kim, Eun-Kyu ; Jang, Mijung ; Kim, Sun Mi ; Park, So Yeon</creator><creatorcontrib>Na, Sei ; Kim, Milim ; Park, Yujun ; Kwon, Hyun Jung ; Shin, Hee-Chul ; Kim, Eun-Kyu ; Jang, Mijung ; Kim, Sun Mi ; Park, So Yeon</creatorcontrib><description>Background
Human epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits of antibody–drug conjugates (ADCs) in breast cancer patients. We aimed to investigate the concordance of HER2 status between core needle biopsy (CNB) and subsequent surgical resection specimens focusing on the HER2-low status.
Methods
This retrospective study was conducted in 1,387 patients with invasive breast cancer whose HER2 status was evaluated in both CNB and surgical resection specimens. The discordance rates between CNB and surgical resection specimens and the clinicopathological features associated with HER2 status discordance were analyzed.
Results
The overall concordance rates of HER2 status between CNB and surgical resection specimens were 99.0% (
κ
= 0.925) for two-group classification (negative vs. positive) and 78.5% (
κ
= 0.587) for three-group classification (zero vs. low vs. positive). The largest discordance occurred in CNB-HER2-zero cases with 42.8% of them reclassified as HER2-low in surgical resection. HER2 discordance was associated with lower histologic grade, tumor multiplicity, and luminal A subtype. In multivariate analysis, tumor multiplicity and estrogen receptor (ER) positivity were independent predictive factors for HER2-zero to low conversion.
Conclusions
Incorporation of HER2-low category in HER2 status interpretation reduces the concordance rate between CNB and surgical resection specimens. Tumor multiplicity and ER positivity are predictive factors for conversion from HER2-zero to HER2-low status. Therefore, HER2 status should be re-evaluated in resection specimens when considering ADCs in tumors exhibiting multiplicity and ER positivity.</description><identifier>ISSN: 1340-6868</identifier><identifier>ISSN: 1880-4233</identifier><identifier>EISSN: 1880-4233</identifier><identifier>DOI: 10.1007/s12282-024-01585-3</identifier><identifier>PMID: 38643429</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - metabolism ; Biopsy, Large-Core Needle ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Cancer Research ; Female ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original ; Original Article ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Retrospective Studies ; Surgery ; Surgical Oncology</subject><ispartof>Breast cancer (Tokyo, Japan), 2024-07, Vol.31 (4), p.705-716</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c398t-9a3ab76f0756838dcf7c93447dbc01c54d9ac14726b58423e19f0a882b3ddef03</cites><orcidid>0000-0002-0299-7268</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12282-024-01585-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12282-024-01585-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38643429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Na, Sei</creatorcontrib><creatorcontrib>Kim, Milim</creatorcontrib><creatorcontrib>Park, Yujun</creatorcontrib><creatorcontrib>Kwon, Hyun Jung</creatorcontrib><creatorcontrib>Shin, Hee-Chul</creatorcontrib><creatorcontrib>Kim, Eun-Kyu</creatorcontrib><creatorcontrib>Jang, Mijung</creatorcontrib><creatorcontrib>Kim, Sun Mi</creatorcontrib><creatorcontrib>Park, So Yeon</creatorcontrib><title>Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status</title><title>Breast cancer (Tokyo, Japan)</title><addtitle>Breast Cancer</addtitle><addtitle>Breast Cancer</addtitle><description>Background
Human epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits of antibody–drug conjugates (ADCs) in breast cancer patients. We aimed to investigate the concordance of HER2 status between core needle biopsy (CNB) and subsequent surgical resection specimens focusing on the HER2-low status.
Methods
This retrospective study was conducted in 1,387 patients with invasive breast cancer whose HER2 status was evaluated in both CNB and surgical resection specimens. The discordance rates between CNB and surgical resection specimens and the clinicopathological features associated with HER2 status discordance were analyzed.
Results
The overall concordance rates of HER2 status between CNB and surgical resection specimens were 99.0% (
κ
= 0.925) for two-group classification (negative vs. positive) and 78.5% (
κ
= 0.587) for three-group classification (zero vs. low vs. positive). The largest discordance occurred in CNB-HER2-zero cases with 42.8% of them reclassified as HER2-low in surgical resection. HER2 discordance was associated with lower histologic grade, tumor multiplicity, and luminal A subtype. In multivariate analysis, tumor multiplicity and estrogen receptor (ER) positivity were independent predictive factors for HER2-zero to low conversion.
Conclusions
Incorporation of HER2-low category in HER2 status interpretation reduces the concordance rate between CNB and surgical resection specimens. Tumor multiplicity and ER positivity are predictive factors for conversion from HER2-zero to HER2-low status. Therefore, HER2 status should be re-evaluated in resection specimens when considering ADCs in tumors exhibiting multiplicity and ER positivity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy, Large-Core Needle</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer Research</subject><subject>Female</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1340-6868</issn><issn>1880-4233</issn><issn>1880-4233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UdtqFDEYDqLYWn0BLySX3ozmNJOMNyJLD0JBkPY6ZDL_bFNmkzV_xrLv4QOb7a5Fb4RAAt8pfB8hbzn7wBnTH5ELYUTDhGoYb03byGfklBvDGiWkfF7fUrGmM505Ia8Q7xlTUrPuJTmRplNSif6U_Fql6FMeXfRA00Svzr8LisWVBekA5QEg0ooDjQDjDHQIaYs76uJIccnr4N1MMyD4ElKkuAUfNhBxbzVkcFio31vnT1VSj5t3GJBOyS8Y4ppWTbmDx9RmTg_H5NfkxeRmhDfH-4zcXpzfrK6a62-XX1dfrhsve1Oa3kk36G5iuu2MNKOftO-lUnocPOO-VWPvPFdadENraiXA-4k5Y8QgxxEmJs_I54Pvdhk2MHqIJbvZbnPYuLyzyQX7LxLDnV2nn5Zz3ived9Xh_dEhpx8LYLGbgB7m2UVIC1pZK2daGM0rVRyoPifEDNNTDmd2v6c97GnrnvZxTyur6N3fP3yS_BmwEuSBgBWKa8j2Pi259oz_s_0NAbyucg</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Na, Sei</creator><creator>Kim, Milim</creator><creator>Park, Yujun</creator><creator>Kwon, Hyun Jung</creator><creator>Shin, Hee-Chul</creator><creator>Kim, Eun-Kyu</creator><creator>Jang, Mijung</creator><creator>Kim, Sun Mi</creator><creator>Park, So Yeon</creator><general>Springer Nature Singapore</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0299-7268</orcidid></search><sort><creationdate>20240701</creationdate><title>Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status</title><author>Na, Sei ; Kim, Milim ; Park, Yujun ; Kwon, Hyun Jung ; Shin, Hee-Chul ; Kim, Eun-Kyu ; Jang, Mijung ; Kim, Sun Mi ; Park, So Yeon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-9a3ab76f0756838dcf7c93447dbc01c54d9ac14726b58423e19f0a882b3ddef03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy, Large-Core Needle</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Cancer Research</topic><topic>Female</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Na, Sei</creatorcontrib><creatorcontrib>Kim, Milim</creatorcontrib><creatorcontrib>Park, Yujun</creatorcontrib><creatorcontrib>Kwon, Hyun Jung</creatorcontrib><creatorcontrib>Shin, Hee-Chul</creatorcontrib><creatorcontrib>Kim, Eun-Kyu</creatorcontrib><creatorcontrib>Jang, Mijung</creatorcontrib><creatorcontrib>Kim, Sun Mi</creatorcontrib><creatorcontrib>Park, So Yeon</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Na, Sei</au><au>Kim, Milim</au><au>Park, Yujun</au><au>Kwon, Hyun Jung</au><au>Shin, Hee-Chul</au><au>Kim, Eun-Kyu</au><au>Jang, Mijung</au><au>Kim, Sun Mi</au><au>Park, So Yeon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status</atitle><jtitle>Breast cancer (Tokyo, Japan)</jtitle><stitle>Breast Cancer</stitle><addtitle>Breast Cancer</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>31</volume><issue>4</issue><spage>705</spage><epage>716</epage><pages>705-716</pages><issn>1340-6868</issn><issn>1880-4233</issn><eissn>1880-4233</eissn><abstract>Background
Human epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits of antibody–drug conjugates (ADCs) in breast cancer patients. We aimed to investigate the concordance of HER2 status between core needle biopsy (CNB) and subsequent surgical resection specimens focusing on the HER2-low status.
Methods
This retrospective study was conducted in 1,387 patients with invasive breast cancer whose HER2 status was evaluated in both CNB and surgical resection specimens. The discordance rates between CNB and surgical resection specimens and the clinicopathological features associated with HER2 status discordance were analyzed.
Results
The overall concordance rates of HER2 status between CNB and surgical resection specimens were 99.0% (
κ
= 0.925) for two-group classification (negative vs. positive) and 78.5% (
κ
= 0.587) for three-group classification (zero vs. low vs. positive). The largest discordance occurred in CNB-HER2-zero cases with 42.8% of them reclassified as HER2-low in surgical resection. HER2 discordance was associated with lower histologic grade, tumor multiplicity, and luminal A subtype. In multivariate analysis, tumor multiplicity and estrogen receptor (ER) positivity were independent predictive factors for HER2-zero to low conversion.
Conclusions
Incorporation of HER2-low category in HER2 status interpretation reduces the concordance rate between CNB and surgical resection specimens. Tumor multiplicity and ER positivity are predictive factors for conversion from HER2-zero to HER2-low status. Therefore, HER2 status should be re-evaluated in resection specimens when considering ADCs in tumors exhibiting multiplicity and ER positivity.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38643429</pmid><doi>10.1007/s12282-024-01585-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0299-7268</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Breast cancer (Tokyo, Japan), 2024-07, Vol.31 (4), p.705-716 |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Biopsy, Large-Core Needle Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer Research Female Humans Medicine Medicine & Public Health Middle Aged Oncology Original Original Article Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Retrospective Studies Surgery Surgical Oncology |
| title | Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status |
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