The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

TIMELESS (TIM) in the fork protection complex acts as a scaffold of the replisome to prevent its uncoupling and ensure efficient DNA replication fork progression. Nevertheless, its underlying basis for coordinating leading and lagging strand synthesis to limit single-stranded DNA (ssDNA) exposure re...

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Veröffentlicht in:	Nucleic acids research 2024-06, Vol.52 (11), p.6424-6440
Hauptverfasser:	Saldanha, Joanne, Rageul, Julie, Patel, Jinal A, Phi, Amy L, Lo, Natalie, Park, Jennifer J, Kim, Hyungjin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism DNA - genetics DNA - metabolism DNA Ligase ATP - genetics DNA Ligase ATP - metabolism DNA Repair DNA Replication DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Flap Endonucleases - genetics Flap Endonucleases - metabolism Genome Integrity, Repair and Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism X-ray Repair Cross Complementing Protein 1 - genetics X-ray Repair Cross Complementing Protein 1 - metabolism
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