MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

N-terminal arginine (NTR) methylation is a conserved feature of PIWI proteins, which are central components of the PIWI-interacting RNA (piRNA) pathway. The significance and precise function of PIWI NTR methylation in mammals remains unknown. In mice, PIWI NTRs bind Tudor domain containing proteins...

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Veröffentlicht in:	Nucleic acids research 2024-06, Vol.52 (11), p.6558-6570
Hauptverfasser:	Vrettos, Nicholas, Oppelt, Jan, Zoch, Ansgar, Sgourdou, Paraskevi, Yoshida, Haruka, Song, Brian, Fink, Ryan, O'Carroll, Dónal, Mourelatos, Zissimos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - genetics Arginine - metabolism Argonaute Proteins - genetics Argonaute Proteins - metabolism DNA Transposable Elements Male Mice Pachytene Stage Piwi-Interacting RNA RNA and RNA-protein complexes RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-Binding Proteins Spermatogenesis Tudor Domain
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