Single-stranded pre-methylated 5mC adapters uncover the methylation profile of plasma ultrashort Single-stranded cell-free DNA

Whole-genome bisulfite sequencing (BS-Seq) measures cytosine methylation changes at single-base resolution and can be used to profile cell-free DNA (cfDNA). In plasma, ultrashort single-stranded cfDNA (uscfDNA, ∼50 nt) has been identified together with 167 bp double-stranded mononucleosomal cell-fre...

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Veröffentlicht in:	Nucleic acids research 2024-06, Vol.52 (11), p.e50-e50
Hauptverfasser:	Cheng, Jordan C, Swarup, Neeti, Morselli, Marco, Huang, Wei-Lun, Aziz, Mohammad, Caggiano, Christa, Kordi, Misagh, Patel, Abhijit A, Chia, David, Kim, Yong, Li, Feng, Wei, Fang, Zaitlen, Noah, Krysan, Kostyantyn, Dubinett, Steve, Pellegrini, Matteo, Wong, David T W
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Cell-Free Nucleic Acids - blood Cell-Free Nucleic Acids - genetics CpG Islands DNA Methylation DNA, Single-Stranded - blood DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Humans Lung Neoplasms - blood Lung Neoplasms - genetics Methods Promoter Regions, Genetic Sequence Analysis, DNA - methods Sulfites - chemistry Whole Genome Sequencing - methods
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