Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma
In a phase 1b–2 study, a five-agent treatment aimed at tumor survival pathways in relapsed and refractory diffuse large B-cell lymphoma was associated with a complete response in 38% of the patients.
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| Veröffentlicht in: | The New England journal of medicine 2024-06, Vol.390 (23), p.2143-2155 |
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| container_issue | 23 |
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| container_title | The New England journal of medicine |
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| creator | Melani, Christopher Lakhotia, Rahul Pittaluga, Stefania Phelan, James D. Huang, Da Wei Wright, George Simard, Jillian Muppidi, Jagan Thomas, Craig J. Ceribelli, Michele Tosto, Frances A. Yang, Yandan Xu, Weihong Davies-Hill, Theresa Pack, Svetlana D. Peer, Cody J. Arisa, Oluwatobi Mena, Esther Lindenberg, Liza Bergvall, Ethan Portell, Craig A. Farah, Rafic J. Lee, Seung Tae Pradhan, Amynah Morrison, Candis Tadese, Atekelt Juanitez, Anna Marie Lu, Crystal Jacob, Allison Simmons, Heidi Figg, William D. Steinberg, Seth M. Jaffe, Elaine S. Roschewski, Mark Staudt, Louis M. Wilson, Wyndham H. |
| description | In a phase 1b–2 study, a five-agent treatment aimed at tumor survival pathways in relapsed and refractory diffuse large B-cell lymphoma was associated with a complete response in 38% of the patients. |
| doi_str_mv | 10.1056/NEJMoa2401532 |
| format | Article |
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Lakhotia, Rahul ; Pittaluga, Stefania ; Phelan, James D. ; Huang, Da Wei ; Wright, George ; Simard, Jillian ; Muppidi, Jagan ; Thomas, Craig J. ; Ceribelli, Michele ; Tosto, Frances A. ; Yang, Yandan ; Xu, Weihong ; Davies-Hill, Theresa ; Pack, Svetlana D. ; Peer, Cody J. ; Arisa, Oluwatobi ; Mena, Esther ; Lindenberg, Liza ; Bergvall, Ethan ; Portell, Craig A. ; Farah, Rafic J. ; Lee, Seung Tae ; Pradhan, Amynah ; Morrison, Candis ; Tadese, Atekelt ; Juanitez, Anna Marie ; Lu, Crystal ; Jacob, Allison ; Simmons, Heidi ; Figg, William D. ; Steinberg, Seth M. ; Jaffe, Elaine S. ; Roschewski, Mark ; Staudt, Louis M. ; Wilson, Wyndham H.</creator><creatorcontrib>Melani, Christopher ; Lakhotia, Rahul ; Pittaluga, Stefania ; Phelan, James D. ; Huang, Da Wei ; Wright, George ; Simard, Jillian ; Muppidi, Jagan ; Thomas, Craig J. ; Ceribelli, Michele ; Tosto, Frances A. ; Yang, Yandan ; Xu, Weihong ; Davies-Hill, Theresa ; Pack, Svetlana D. ; Peer, Cody J. ; Arisa, Oluwatobi ; Mena, Esther ; Lindenberg, Liza ; Bergvall, Ethan ; Portell, Craig A. ; Farah, Rafic J. ; Lee, Seung Tae ; Pradhan, Amynah ; Morrison, Candis ; Tadese, Atekelt ; Juanitez, Anna Marie ; Lu, Crystal ; Jacob, Allison ; Simmons, Heidi ; Figg, William D. ; Steinberg, Seth M. ; Jaffe, Elaine S. ; Roschewski, Mark ; Staudt, Louis M. ; Wilson, Wyndham H.</creatorcontrib><description>In a phase 1b–2 study, a five-agent treatment aimed at tumor survival pathways in relapsed and refractory diffuse large B-cell lymphoma was associated with a complete response in 38% of the patients.</description><identifier>ISSN: 0028-4793</identifier><identifier>ISSN: 1533-4406</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2401532</identifier><identifier>PMID: 38899693</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject><![CDATA[Adenine - administration & dosage ; Adenine - adverse effects ; Adenine - analogs & derivatives ; Adenine - therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized - administration & dosage ; Antibodies, Monoclonal, Humanized - adverse effects ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bcl-2 protein ; Bcl-6 protein ; Biopsy ; Bridged Bicyclo Compounds, Heterocyclic - administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic - adverse effects ; Bridged Bicyclo Compounds, Heterocyclic - therapeutic use ; Disease prevention ; Drug development ; Drug dosages ; Female ; Hematology ; Hemorrhage ; Humans ; Kinases ; Lenalidomide - administration & dosage ; Lenalidomide - adverse effects ; Lenalidomide - therapeutic use ; Leukemia ; Lymphocytes B ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse - drug therapy ; Lymphoma, Large B-Cell, Diffuse - mortality ; Male ; Medical prognosis ; Middle Aged ; Molecular Targeted Therapy ; Myc protein ; Neutropenia ; Oncology ; Piperidines - administration & dosage ; Piperidines - adverse effects ; Piperidines - therapeutic use ; Prednisone ; Prednisone - administration & dosage ; Prednisone - adverse effects ; Prednisone - therapeutic use ; Progression-Free Survival ; Pyrazoles - administration & dosage ; Pyrazoles - adverse effects ; Pyrazoles - therapeutic use ; Pyrimidines - administration & dosage ; Pyrimidines - adverse effects ; Pyrimidines - therapeutic use ; Recurrence ; Sulfonamides - administration & dosage ; Sulfonamides - adverse effects ; Sulfonamides - therapeutic use ; Thrombocytopenia ; Tomography ; Treatments in Oncology]]></subject><ispartof>The New England journal of medicine, 2024-06, Vol.390 (23), p.2143-2155</ispartof><rights>Copyright © 2024 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2024 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-139c9daf5b70f42abba680505057ed102211c9a203b39b9a448c59fdcfcc0ed23</citedby><cites>FETCH-LOGICAL-c337t-139c9daf5b70f42abba680505057ed102211c9a203b39b9a448c59fdcfcc0ed23</cites><orcidid>0000-0002-9661-4570 ; 0000-0003-2428-5613 ; 0000-0002-2862-9711 ; 0000-0002-6645-2435 ; 0000-0003-0278-2635</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3069988100?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38899693$$D View this record in 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Candis</au><au>Tadese, Atekelt</au><au>Juanitez, Anna Marie</au><au>Lu, Crystal</au><au>Jacob, Allison</au><au>Simmons, Heidi</au><au>Figg, William D.</au><au>Steinberg, Seth M.</au><au>Jaffe, Elaine S.</au><au>Roschewski, Mark</au><au>Staudt, Louis M.</au><au>Wilson, Wyndham H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2024-06-20</date><risdate>2024</risdate><volume>390</volume><issue>23</issue><spage>2143</spage><epage>2155</epage><pages>2143-2155</pages><issn>0028-4793</issn><issn>1533-4406</issn><eissn>1533-4406</eissn><abstract>In a phase 1b–2 study, a five-agent treatment aimed at tumor survival pathways in relapsed and refractory diffuse large B-cell lymphoma was associated with a complete response in 38% of the patients.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>38899693</pmid><doi>10.1056/NEJMoa2401532</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-9661-4570</orcidid><orcidid>https://orcid.org/0000-0003-2428-5613</orcidid><orcidid>https://orcid.org/0000-0002-2862-9711</orcidid><orcidid>https://orcid.org/0000-0002-6645-2435</orcidid><orcidid>https://orcid.org/0000-0003-0278-2635</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2024-06, Vol.390 (23), p.2143-2155 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11192235 |
| source | MEDLINE; ProQuest Central UK/Ireland |
| subjects | Adenine - administration & dosage Adenine - adverse effects Adenine - analogs & derivatives Adenine - therapeutic use Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bcl-2 protein Bcl-6 protein Biopsy Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - adverse effects Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Disease prevention Drug development Drug dosages Female Hematology Hemorrhage Humans Kinases Lenalidomide - administration & dosage Lenalidomide - adverse effects Lenalidomide - therapeutic use Leukemia Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - mortality Male Medical prognosis Middle Aged Molecular Targeted Therapy Myc protein Neutropenia Oncology Piperidines - administration & dosage Piperidines - adverse effects Piperidines - therapeutic use Prednisone Prednisone - administration & dosage Prednisone - adverse effects Prednisone - therapeutic use Progression-Free Survival Pyrazoles - administration & dosage Pyrazoles - adverse effects Pyrazoles - therapeutic use Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - therapeutic use Recurrence Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - therapeutic use Thrombocytopenia Tomography Treatments in Oncology |
| title | Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma |
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