A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome
IMPORTANCE: Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest. OBJE...
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| creator | Ni, Mingke Dadon, Ziv Ormerod, Julian O. M Saenen, Johan Hoeksema, Wiert F Antiperovitch, Pavel Tadros, Rafik Christiansen, Morten K Steinberg, Christian Arnaud, Marine Tian, Shanshan Sun, Bo Estillore, John Paul Wang, Ruiwu Khan, Habib R Roston, Thomas M Mazzanti, Andrea Giudicessi, John R Siontis, Konstantinos C Alak, Aiman Acosta, J. Gabriel Divakara Menon, Syamkumar M Tan, Nigel S van der Werf, Christian Nazer, Babak Vivekanantham, Hari Pandya, Tanvi Cunningham, Jennifer Gula, Lorne J Wong, Jorge A Amit, Guy Scheinman, Melvin M Krahn, Andrew D Ackerman, Michael J Priori, Silvia G Gollob, Michael H Healey, Jeff S Sacher, Frederic Nof, Eyal Glikson, Michael Wilde, Arthur A. M Watkins, Hugh Jensen, Henrik K Postema, Pieter G Belhassen, Bernard Chen, S. R. Wayne Roberts, Jason D |
| description | IMPORTANCE: Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest. OBJECTIVE: To explore the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS. DESIGN, SETTING, AND PARTICIPANTS: An international, multicenter, case-control study including individual cases of CRDS, 3 patient control groups (individuals with suspected supraventricular tachycardia; survivors of unexplained cardiac arrest [UCA]; and individuals with genotype-positive catecholaminergic polymorphic ventricular tachycardia [CPVT]), and genetic mouse models (CRDS, wild type, and CPVT were used to define the cellular mechanism) conducted at 10 centers in 7 countries. Patient tracings were recorded between June 2005 and December 2023, and the analyses were performed from April 2023 to December 2023. INTERVENTION: Brief tachycardia and a subsequent pause (either spontaneous or mediated through cardiac pacing). MAIN OUTCOMES AND MEASURES: Change in QT interval and change in T-wave amplitude (defined as the difference between their absolute values on the postpause sinus beat and the last beat prior to tachycardia). RESULTS: Among 10 case patients with CRDS, 45 control patients with suspected supraventricular tachycardia, 10 control patients who experienced UCA, and 3 control patients with genotype-positive CPVT, the median change in T-wave amplitude on the postpause sinus beat (after brief ventricular tachycardia at ≥150 beats/min) was higher in patients with CRDS (P |
| doi_str_mv | 10.1001/jama.2024.8599 |
| format | Article |
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M ; Saenen, Johan ; Hoeksema, Wiert F ; Antiperovitch, Pavel ; Tadros, Rafik ; Christiansen, Morten K ; Steinberg, Christian ; Arnaud, Marine ; Tian, Shanshan ; Sun, Bo ; Estillore, John Paul ; Wang, Ruiwu ; Khan, Habib R ; Roston, Thomas M ; Mazzanti, Andrea ; Giudicessi, John R ; Siontis, Konstantinos C ; Alak, Aiman ; Acosta, J. Gabriel ; Divakara Menon, Syamkumar M ; Tan, Nigel S ; van der Werf, Christian ; Nazer, Babak ; Vivekanantham, Hari ; Pandya, Tanvi ; Cunningham, Jennifer ; Gula, Lorne J ; Wong, Jorge A ; Amit, Guy ; Scheinman, Melvin M ; Krahn, Andrew D ; Ackerman, Michael J ; Priori, Silvia G ; Gollob, Michael H ; Healey, Jeff S ; Sacher, Frederic ; Nof, Eyal ; Glikson, Michael ; Wilde, Arthur A. M ; Watkins, Hugh ; Jensen, Henrik K ; Postema, Pieter G ; Belhassen, Bernard ; Chen, S. R. Wayne ; Roberts, Jason D</creator><creatorcontrib>Ni, Mingke ; Dadon, Ziv ; Ormerod, Julian O. M ; Saenen, Johan ; Hoeksema, Wiert F ; Antiperovitch, Pavel ; Tadros, Rafik ; Christiansen, Morten K ; Steinberg, Christian ; Arnaud, Marine ; Tian, Shanshan ; Sun, Bo ; Estillore, John Paul ; Wang, Ruiwu ; Khan, Habib R ; Roston, Thomas M ; Mazzanti, Andrea ; Giudicessi, John R ; Siontis, Konstantinos C ; Alak, Aiman ; Acosta, J. Gabriel ; Divakara Menon, Syamkumar M ; Tan, Nigel S ; van der Werf, Christian ; Nazer, Babak ; Vivekanantham, Hari ; Pandya, Tanvi ; Cunningham, Jennifer ; Gula, Lorne J ; Wong, Jorge A ; Amit, Guy ; Scheinman, Melvin M ; Krahn, Andrew D ; Ackerman, Michael J ; Priori, Silvia G ; Gollob, Michael H ; Healey, Jeff S ; Sacher, Frederic ; Nof, Eyal ; Glikson, Michael ; Wilde, Arthur A. M ; Watkins, Hugh ; Jensen, Henrik K ; Postema, Pieter G ; Belhassen, Bernard ; Chen, S. R. Wayne ; Roberts, Jason D</creatorcontrib><description>IMPORTANCE: Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest. OBJECTIVE: To explore the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS. DESIGN, SETTING, AND PARTICIPANTS: An international, multicenter, case-control study including individual cases of CRDS, 3 patient control groups (individuals with suspected supraventricular tachycardia; survivors of unexplained cardiac arrest [UCA]; and individuals with genotype-positive catecholaminergic polymorphic ventricular tachycardia [CPVT]), and genetic mouse models (CRDS, wild type, and CPVT were used to define the cellular mechanism) conducted at 10 centers in 7 countries. Patient tracings were recorded between June 2005 and December 2023, and the analyses were performed from April 2023 to December 2023. INTERVENTION: Brief tachycardia and a subsequent pause (either spontaneous or mediated through cardiac pacing). MAIN OUTCOMES AND MEASURES: Change in QT interval and change in T-wave amplitude (defined as the difference between their absolute values on the postpause sinus beat and the last beat prior to tachycardia). RESULTS: Among 10 case patients with CRDS, 45 control patients with suspected supraventricular tachycardia, 10 control patients who experienced UCA, and 3 control patients with genotype-positive CPVT, the median change in T-wave amplitude on the postpause sinus beat (after brief ventricular tachycardia at ≥150 beats/min) was higher in patients with CRDS (P < .001). The smallest change in T-wave amplitude was 0.250 mV for a CRDS case patient compared with the largest change in T-wave amplitude of 0.160 mV for a control patient, indicating 100% discrimination. Although the median change in QT interval was longer in CRDS cases (P = .002), an overlap between the cases and controls was present. The genetic mouse models recapitulated the findings observed in humans and suggested the repolarization response was secondary to a pathologically large systolic release of calcium from the sarcoplasmic reticulum. CONCLUSIONS AND RELEVANCE: There is a unique repolarization response on an electrocardiogram after provocation with brief tachycardia and a subsequent pause in CRDS cases and mouse models, which is absent from the controls. If these findings are confirmed in larger studies, this easy to perform maneuver may serve as an effective clinical diagnostic test for CRDS and become an important part of the evaluation of cardiac arrest.</description><identifier>ISSN: 0098-7484</identifier><identifier>ISSN: 1538-3598</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.2024.8599</identifier><identifier>PMID: 38900490</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adolescent ; Adult ; Animals ; Arrhythmias, Cardiac - diagnosis ; Arrhythmias, Cardiac - etiology ; Calcium - blood ; Calcium - metabolism ; Case-Control Studies ; Disease Models, Animal ; Electrocardiography ; Female ; Heart Arrest - diagnosis ; Heart Arrest - etiology ; Humans ; Male ; Mice ; Middle Aged ; Online First ; Preliminary Communication ; Ryanodine Receptor Calcium Release Channel - genetics ; Tachycardia, Supraventricular - diagnosis ; Tachycardia, Supraventricular - etiology ; Tachycardia, Supraventricular - physiopathology ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - physiopathology ; Young Adult</subject><ispartof>JAMA : the journal of the American Medical Association, 2024-07, Vol.332 (3), p.204-213</ispartof><rights>Copyright 2024 American Medical Association. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a255t-16343d4f2329b52d9f8262db31b9e004e94ddead5b469b47007bceba4af87c5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jama/articlepdf/10.1001/jama.2024.8599$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.8599$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,776,780,881,3327,27903,27904,76235,76238</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38900490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Mingke</creatorcontrib><creatorcontrib>Dadon, Ziv</creatorcontrib><creatorcontrib>Ormerod, Julian O. M</creatorcontrib><creatorcontrib>Saenen, Johan</creatorcontrib><creatorcontrib>Hoeksema, Wiert F</creatorcontrib><creatorcontrib>Antiperovitch, Pavel</creatorcontrib><creatorcontrib>Tadros, Rafik</creatorcontrib><creatorcontrib>Christiansen, Morten K</creatorcontrib><creatorcontrib>Steinberg, Christian</creatorcontrib><creatorcontrib>Arnaud, Marine</creatorcontrib><creatorcontrib>Tian, Shanshan</creatorcontrib><creatorcontrib>Sun, Bo</creatorcontrib><creatorcontrib>Estillore, John Paul</creatorcontrib><creatorcontrib>Wang, Ruiwu</creatorcontrib><creatorcontrib>Khan, Habib R</creatorcontrib><creatorcontrib>Roston, Thomas M</creatorcontrib><creatorcontrib>Mazzanti, Andrea</creatorcontrib><creatorcontrib>Giudicessi, John R</creatorcontrib><creatorcontrib>Siontis, Konstantinos C</creatorcontrib><creatorcontrib>Alak, Aiman</creatorcontrib><creatorcontrib>Acosta, J. Gabriel</creatorcontrib><creatorcontrib>Divakara Menon, Syamkumar M</creatorcontrib><creatorcontrib>Tan, Nigel S</creatorcontrib><creatorcontrib>van der Werf, Christian</creatorcontrib><creatorcontrib>Nazer, Babak</creatorcontrib><creatorcontrib>Vivekanantham, Hari</creatorcontrib><creatorcontrib>Pandya, Tanvi</creatorcontrib><creatorcontrib>Cunningham, Jennifer</creatorcontrib><creatorcontrib>Gula, Lorne J</creatorcontrib><creatorcontrib>Wong, Jorge A</creatorcontrib><creatorcontrib>Amit, Guy</creatorcontrib><creatorcontrib>Scheinman, Melvin M</creatorcontrib><creatorcontrib>Krahn, Andrew D</creatorcontrib><creatorcontrib>Ackerman, Michael J</creatorcontrib><creatorcontrib>Priori, Silvia G</creatorcontrib><creatorcontrib>Gollob, Michael H</creatorcontrib><creatorcontrib>Healey, Jeff S</creatorcontrib><creatorcontrib>Sacher, Frederic</creatorcontrib><creatorcontrib>Nof, Eyal</creatorcontrib><creatorcontrib>Glikson, Michael</creatorcontrib><creatorcontrib>Wilde, Arthur A. M</creatorcontrib><creatorcontrib>Watkins, Hugh</creatorcontrib><creatorcontrib>Jensen, Henrik K</creatorcontrib><creatorcontrib>Postema, Pieter G</creatorcontrib><creatorcontrib>Belhassen, Bernard</creatorcontrib><creatorcontrib>Chen, S. R. Wayne</creatorcontrib><creatorcontrib>Roberts, Jason D</creatorcontrib><title>A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>IMPORTANCE: Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest. OBJECTIVE: To explore the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS. DESIGN, SETTING, AND PARTICIPANTS: An international, multicenter, case-control study including individual cases of CRDS, 3 patient control groups (individuals with suspected supraventricular tachycardia; survivors of unexplained cardiac arrest [UCA]; and individuals with genotype-positive catecholaminergic polymorphic ventricular tachycardia [CPVT]), and genetic mouse models (CRDS, wild type, and CPVT were used to define the cellular mechanism) conducted at 10 centers in 7 countries. Patient tracings were recorded between June 2005 and December 2023, and the analyses were performed from April 2023 to December 2023. INTERVENTION: Brief tachycardia and a subsequent pause (either spontaneous or mediated through cardiac pacing). MAIN OUTCOMES AND MEASURES: Change in QT interval and change in T-wave amplitude (defined as the difference between their absolute values on the postpause sinus beat and the last beat prior to tachycardia). RESULTS: Among 10 case patients with CRDS, 45 control patients with suspected supraventricular tachycardia, 10 control patients who experienced UCA, and 3 control patients with genotype-positive CPVT, the median change in T-wave amplitude on the postpause sinus beat (after brief ventricular tachycardia at ≥150 beats/min) was higher in patients with CRDS (P < .001). The smallest change in T-wave amplitude was 0.250 mV for a CRDS case patient compared with the largest change in T-wave amplitude of 0.160 mV for a control patient, indicating 100% discrimination. Although the median change in QT interval was longer in CRDS cases (P = .002), an overlap between the cases and controls was present. The genetic mouse models recapitulated the findings observed in humans and suggested the repolarization response was secondary to a pathologically large systolic release of calcium from the sarcoplasmic reticulum. CONCLUSIONS AND RELEVANCE: There is a unique repolarization response on an electrocardiogram after provocation with brief tachycardia and a subsequent pause in CRDS cases and mouse models, which is absent from the controls. If these findings are confirmed in larger studies, this easy to perform maneuver may serve as an effective clinical diagnostic test for CRDS and become an important part of the evaluation of cardiac arrest.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - diagnosis</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Calcium - blood</subject><subject>Calcium - metabolism</subject><subject>Case-Control Studies</subject><subject>Disease Models, Animal</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Arrest - diagnosis</subject><subject>Heart Arrest - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Online First</subject><subject>Preliminary Communication</subject><subject>Ryanodine Receptor Calcium Release Channel - genetics</subject><subject>Tachycardia, Supraventricular - diagnosis</subject><subject>Tachycardia, Supraventricular - etiology</subject><subject>Tachycardia, Supraventricular - physiopathology</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Tachycardia, Ventricular - physiopathology</subject><subject>Young Adult</subject><issn>0098-7484</issn><issn>1538-3598</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkLtPwzAQhy0EoqWwMjCgjCwJ50cae0KQ8pIqIUGZLce5FFd5lLhF6n9Poj4EXjzcd7-7-wi5pBBRAHq7MJWJGDARyVipIzKkMZchj5U8JkMAJcNESDEgZ94voHuUJ6dkwKUCEAqG5OE-SEtXO2vKYOLMvG78ytlghn4VFE0bpKa0bl0F71ii8RhMsHDWYW03wcemztumwnNyUpjS48XuH5HPp8dZ-hJO355f0_tpaFgcr0I65oLnomCcqSxmuSokG7M84zRT2G2DSuQ5mjzOxFhlIgFIMouZEaaQiY2Rj8jdNne5zirMLdar1pR62brKtBvdGKf_V2r3pefNj6aUKpDd9BG52SW0zfe6O1FXzlssS1Njs_aaQwKSJRKgQ6MtatvG-xaLwxwKujeve_O6N697813D9d_tDvhedQdcbYG-b19lskuQnP8C0r2IIQ</recordid><startdate>20240716</startdate><enddate>20240716</enddate><creator>Ni, Mingke</creator><creator>Dadon, Ziv</creator><creator>Ormerod, Julian O. 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Gabriel ; Divakara Menon, Syamkumar M ; Tan, Nigel S ; van der Werf, Christian ; Nazer, Babak ; Vivekanantham, Hari ; Pandya, Tanvi ; Cunningham, Jennifer ; Gula, Lorne J ; Wong, Jorge A ; Amit, Guy ; Scheinman, Melvin M ; Krahn, Andrew D ; Ackerman, Michael J ; Priori, Silvia G ; Gollob, Michael H ; Healey, Jeff S ; Sacher, Frederic ; Nof, Eyal ; Glikson, Michael ; Wilde, Arthur A. M ; Watkins, Hugh ; Jensen, Henrik K ; Postema, Pieter G ; Belhassen, Bernard ; Chen, S. R. 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M</creatorcontrib><creatorcontrib>Watkins, Hugh</creatorcontrib><creatorcontrib>Jensen, Henrik K</creatorcontrib><creatorcontrib>Postema, Pieter G</creatorcontrib><creatorcontrib>Belhassen, Bernard</creatorcontrib><creatorcontrib>Chen, S. R. Wayne</creatorcontrib><creatorcontrib>Roberts, Jason D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Mingke</au><au>Dadon, Ziv</au><au>Ormerod, Julian O. M</au><au>Saenen, Johan</au><au>Hoeksema, Wiert F</au><au>Antiperovitch, Pavel</au><au>Tadros, Rafik</au><au>Christiansen, Morten K</au><au>Steinberg, Christian</au><au>Arnaud, Marine</au><au>Tian, Shanshan</au><au>Sun, Bo</au><au>Estillore, John Paul</au><au>Wang, Ruiwu</au><au>Khan, Habib R</au><au>Roston, Thomas M</au><au>Mazzanti, Andrea</au><au>Giudicessi, John R</au><au>Siontis, Konstantinos C</au><au>Alak, Aiman</au><au>Acosta, J. Gabriel</au><au>Divakara Menon, Syamkumar M</au><au>Tan, Nigel S</au><au>van der Werf, Christian</au><au>Nazer, Babak</au><au>Vivekanantham, Hari</au><au>Pandya, Tanvi</au><au>Cunningham, Jennifer</au><au>Gula, Lorne J</au><au>Wong, Jorge A</au><au>Amit, Guy</au><au>Scheinman, Melvin M</au><au>Krahn, Andrew D</au><au>Ackerman, Michael J</au><au>Priori, Silvia G</au><au>Gollob, Michael H</au><au>Healey, Jeff S</au><au>Sacher, Frederic</au><au>Nof, Eyal</au><au>Glikson, Michael</au><au>Wilde, Arthur A. M</au><au>Watkins, Hugh</au><au>Jensen, Henrik K</au><au>Postema, Pieter G</au><au>Belhassen, Bernard</au><au>Chen, S. R. Wayne</au><au>Roberts, Jason D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>2024-07-16</date><risdate>2024</risdate><volume>332</volume><issue>3</issue><spage>204</spage><epage>213</epage><pages>204-213</pages><issn>0098-7484</issn><issn>1538-3598</issn><eissn>1538-3598</eissn><abstract>IMPORTANCE: Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest. OBJECTIVE: To explore the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS. DESIGN, SETTING, AND PARTICIPANTS: An international, multicenter, case-control study including individual cases of CRDS, 3 patient control groups (individuals with suspected supraventricular tachycardia; survivors of unexplained cardiac arrest [UCA]; and individuals with genotype-positive catecholaminergic polymorphic ventricular tachycardia [CPVT]), and genetic mouse models (CRDS, wild type, and CPVT were used to define the cellular mechanism) conducted at 10 centers in 7 countries. Patient tracings were recorded between June 2005 and December 2023, and the analyses were performed from April 2023 to December 2023. INTERVENTION: Brief tachycardia and a subsequent pause (either spontaneous or mediated through cardiac pacing). MAIN OUTCOMES AND MEASURES: Change in QT interval and change in T-wave amplitude (defined as the difference between their absolute values on the postpause sinus beat and the last beat prior to tachycardia). RESULTS: Among 10 case patients with CRDS, 45 control patients with suspected supraventricular tachycardia, 10 control patients who experienced UCA, and 3 control patients with genotype-positive CPVT, the median change in T-wave amplitude on the postpause sinus beat (after brief ventricular tachycardia at ≥150 beats/min) was higher in patients with CRDS (P < .001). The smallest change in T-wave amplitude was 0.250 mV for a CRDS case patient compared with the largest change in T-wave amplitude of 0.160 mV for a control patient, indicating 100% discrimination. Although the median change in QT interval was longer in CRDS cases (P = .002), an overlap between the cases and controls was present. The genetic mouse models recapitulated the findings observed in humans and suggested the repolarization response was secondary to a pathologically large systolic release of calcium from the sarcoplasmic reticulum. CONCLUSIONS AND RELEVANCE: There is a unique repolarization response on an electrocardiogram after provocation with brief tachycardia and a subsequent pause in CRDS cases and mouse models, which is absent from the controls. If these findings are confirmed in larger studies, this easy to perform maneuver may serve as an effective clinical diagnostic test for CRDS and become an important part of the evaluation of cardiac arrest.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>38900490</pmid><doi>10.1001/jama.2024.8599</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 2024-07, Vol.332 (3), p.204-213 |
| issn | 0098-7484 1538-3598 1538-3598 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11190834 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adolescent Adult Animals Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - etiology Calcium - blood Calcium - metabolism Case-Control Studies Disease Models, Animal Electrocardiography Female Heart Arrest - diagnosis Heart Arrest - etiology Humans Male Mice Middle Aged Online First Preliminary Communication Ryanodine Receptor Calcium Release Channel - genetics Tachycardia, Supraventricular - diagnosis Tachycardia, Supraventricular - etiology Tachycardia, Supraventricular - physiopathology Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - etiology Tachycardia, Ventricular - physiopathology Young Adult |
| title | A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome |
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