Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia

Hypoxia poses a significant challenge to the effectiveness of radiotherapy in head and neck squamous cell carcinoma (HNSCC) patients, and it is imperative to discover novel approaches to overcome this. In this study, we investigated the underlying mechanisms contributing to x‐ray radioresistance in...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2024-06, Vol.28 (12), p.e18482-n/a
Hauptverfasser:	Hill, Rhianna M., Li, Chun, Hughes, Jonathan R., Rocha, Sonia, Grundy, Gabrielle J., Parsons, Jason L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Autophagy Autophagy - genetics Autophagy - radiation effects Beclin-1 - genetics Beclin-1 - metabolism BNIP3 protein Cell cycle Cell death Cell Hypoxia - genetics Cell Line, Tumor Chemotherapy DNA Breaks, Double-Stranded - radiation effects DNA damage DNA damage repair DNA repair DNA Repair - genetics DNA Repair - radiation effects Head & neck cancer head and neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Human papillomavirus Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Kinases Larynx Medical prognosis Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Original Patients Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Radiation therapy Radiation Tolerance - genetics Radioresistance Radiosensitivity radiotherapy RNA, Small Interfering - genetics RNA, Small Interfering - metabolism siRNA Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - radiotherapy Tumor Suppressor Proteins Tumors X-Rays
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