Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis
Background and Objective Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as motor neuron disease (MND), ALS also affects non‐motor regions, such as the hypothalamus. This study aimed to quantify the hypothalamic subregion volumes in...
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| Veröffentlicht in: | CNS neuroscience & therapeutics 2024-06, Vol.30 (6), p.e14801-n/a |
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| creator | Ghaderi, Sadegh Fatehi, Farzad Kalra, Sanjay Mohammadi, Sana Zemorshidi, Fariba Ramezani, Mahtab Hesami, Omid Pezeshgi, Saharnaz Batouli, Seyed Amir Hossein |
| description | Background and Objective
Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as motor neuron disease (MND), ALS also affects non‐motor regions, such as the hypothalamus. This study aimed to quantify the hypothalamic subregion volumes in patients with ALS versus healthy controls (HCs) and examine their associations with demographic and clinical features.
Methods
Forty‐eight participants (24 ALS patients and 24 HCs) underwent structural MRI. A deep convolutional neural network was used for the automated segmentation of the hypothalamic subunits, including the anterior‐superior (a‐sHyp), anterior‐inferior (a‐iHyp), superior tuberal (supTub), inferior tuberal (infTub), and posterior (posHyp). The neural network was validated using FreeSurfer v7.4.1, with individual head size variations normalized using total intracranial volume (TIV) normalization. Statistical analyses were performed for comparisons using independent sample t‐tests. Correlations were calculated using Pearson's and Spearman's tests (p 41 and those with a disease duration of 9 months or less.
Discussion and Conclusion
The main finding suggests atrophy of the left a‐sHyp hypothalamic subunit in patients with ALS, which is supported by previous research as an extra‐motor neuroimaging finding for ALS.
This study reveals significant atrophy in the left anterior‐superior hypothalamus of ALS patients compared with healthy controls, highlighting the disease's broader neurological impact beyond motor neuron degeneration. |
| doi_str_mv | 10.1111/cns.14801 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11183167</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A800450235</galeid><sourcerecordid>A800450235</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4011-536c6f64a955901343ac0996a3699963e7908ca5ee469ee569c7aa84f87dffc53</originalsourceid><addsrcrecordid>eNp1kUtuFDEQhi1EREJgwQVQS2zIYiZ2_F6haEQAKYIFj63leMppR267aXeDZpcj5IycBM90MgIk7EWV7K_-eiH0guAlqefUpbIkTGHyCB0RyfmCa6Yf732KD9HTUm4wFmdKqyfokCqlJFHyCLXfcpw6aGIupQmpGdvqgx8bm0YYQh5-3d6Vqd-5TZmuphTGJvsd1276PLY22m7axdpuk8ch921wTbQ13MamuAhDLqE8QwfexgLP7-0x-nrx9svq_eLy07sPq_PLhWOYkAWnwgkvmNWca0woo9ZhrYWlQldDQWqsnOUATGgALrST1irmlVx77zg9Rm9m3X666mDtII21DtMPobPDxmQbzN8_KbTmOv8wdZCKEiGrwut7hSF_n6CMpgvFQYw2QZ6KoVhiqRkjuqKv_kFv8jSk2t-WYkIRyXClljN1bSOYkHydknX1rqELLifwob6fK4wZx2d028PJHODq6MoAfl8-wds6iakbN7uNV_bln_3uyYcVV-B0Bn7WLJv_K5nVx8-z5G_a07e7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3074681740</pqid></control><display><type>article</type><title>Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><creator>Ghaderi, Sadegh ; Fatehi, Farzad ; Kalra, Sanjay ; Mohammadi, Sana ; Zemorshidi, Fariba ; Ramezani, Mahtab ; Hesami, Omid ; Pezeshgi, Saharnaz ; Batouli, Seyed Amir Hossein</creator><creatorcontrib>Ghaderi, Sadegh ; Fatehi, Farzad ; Kalra, Sanjay ; Mohammadi, Sana ; Zemorshidi, Fariba ; Ramezani, Mahtab ; Hesami, Omid ; Pezeshgi, Saharnaz ; Batouli, Seyed Amir Hossein</creatorcontrib><description>Background and Objective
Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as motor neuron disease (MND), ALS also affects non‐motor regions, such as the hypothalamus. This study aimed to quantify the hypothalamic subregion volumes in patients with ALS versus healthy controls (HCs) and examine their associations with demographic and clinical features.
Methods
Forty‐eight participants (24 ALS patients and 24 HCs) underwent structural MRI. A deep convolutional neural network was used for the automated segmentation of the hypothalamic subunits, including the anterior‐superior (a‐sHyp), anterior‐inferior (a‐iHyp), superior tuberal (supTub), inferior tuberal (infTub), and posterior (posHyp). The neural network was validated using FreeSurfer v7.4.1, with individual head size variations normalized using total intracranial volume (TIV) normalization. Statistical analyses were performed for comparisons using independent sample t‐tests. Correlations were calculated using Pearson's and Spearman's tests (p < 0.05). The standard mean difference (SMD) was used to compare the mean differences between parametric variables.
Results
The volume of the left a‐sHyp hypothalamic subunit was significantly lower in ALS patients than in HCs (p = 0.023, SMD = ‐0.681). No significant correlation was found between the volume of the hypothalamic subunits, body mass index (BMI), and ALSFRS‐R in patients with ALS. However, right a‐sHyp (r = 0.420, p = 0.041) was correlated with disease duration, whereas right supTub (r = −0.471, p = 0.020) and left postHyp (r = −0.406, p = 0.049) were negatively correlated with age. There was no significant difference in the volume of hypothalamic subunits between males and females, and no significant difference was found between patients with revised ALS Functional Rating Scale (ALSFRS‐R) scores ≤41 and >41 and those with a disease duration of 9 months or less.
Discussion and Conclusion
The main finding suggests atrophy of the left a‐sHyp hypothalamic subunit in patients with ALS, which is supported by previous research as an extra‐motor neuroimaging finding for ALS.
This study reveals significant atrophy in the left anterior‐superior hypothalamus of ALS patients compared with healthy controls, highlighting the disease's broader neurological impact beyond motor neuron degeneration.</description><identifier>ISSN: 1755-5930</identifier><identifier>ISSN: 1755-5949</identifier><identifier>EISSN: 1755-5949</identifier><identifier>DOI: 10.1111/cns.14801</identifier><identifier>PMID: 38887187</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; ALS ; Alzheimer's disease ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - diagnostic imaging ; Amyotrophic Lateral Sclerosis - pathology ; Atrophy ; Automation ; Body mass index ; Brain research ; Female ; Humans ; Huntingtons disease ; Hypothalamus ; Hypothalamus (anterior) ; Hypothalamus (lateral) ; Hypothalamus - diagnostic imaging ; Hypothalamus - pathology ; Image processing ; Magnetic Resonance Imaging ; Male ; Metabolism ; Middle Aged ; Motor neuron diseases ; MRI ; Neural networks ; Neurodegeneration ; Neuroimaging ; Neurons ; Normal distribution ; Original ; Paralysis ; Parkinson's disease ; Patients ; Physiology ; Software ; Somatotropin ; Statistical analysis ; Variables</subject><ispartof>CNS neuroscience & therapeutics, 2024-06, Vol.30 (6), p.e14801-n/a</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.</rights><rights>COPYRIGHT 2024 John Wiley & Sons, Inc.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4011-536c6f64a955901343ac0996a3699963e7908ca5ee469ee569c7aa84f87dffc53</cites><orcidid>0000-0002-2286-9052 ; 0000-0003-4762-8746 ; 0000-0002-1148-3998 ; 0000-0002-6774-7825 ; 0000-0001-7421-3218 ; 0000-0002-9157-4522 ; 0000-0003-4589-5947 ; 0000-0003-1334-8826</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11183167/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11183167/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38887187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghaderi, Sadegh</creatorcontrib><creatorcontrib>Fatehi, Farzad</creatorcontrib><creatorcontrib>Kalra, Sanjay</creatorcontrib><creatorcontrib>Mohammadi, Sana</creatorcontrib><creatorcontrib>Zemorshidi, Fariba</creatorcontrib><creatorcontrib>Ramezani, Mahtab</creatorcontrib><creatorcontrib>Hesami, Omid</creatorcontrib><creatorcontrib>Pezeshgi, Saharnaz</creatorcontrib><creatorcontrib>Batouli, Seyed Amir Hossein</creatorcontrib><title>Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis</title><title>CNS neuroscience & therapeutics</title><addtitle>CNS Neurosci Ther</addtitle><description>Background and Objective
Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as motor neuron disease (MND), ALS also affects non‐motor regions, such as the hypothalamus. This study aimed to quantify the hypothalamic subregion volumes in patients with ALS versus healthy controls (HCs) and examine their associations with demographic and clinical features.
Methods
Forty‐eight participants (24 ALS patients and 24 HCs) underwent structural MRI. A deep convolutional neural network was used for the automated segmentation of the hypothalamic subunits, including the anterior‐superior (a‐sHyp), anterior‐inferior (a‐iHyp), superior tuberal (supTub), inferior tuberal (infTub), and posterior (posHyp). The neural network was validated using FreeSurfer v7.4.1, with individual head size variations normalized using total intracranial volume (TIV) normalization. Statistical analyses were performed for comparisons using independent sample t‐tests. Correlations were calculated using Pearson's and Spearman's tests (p < 0.05). The standard mean difference (SMD) was used to compare the mean differences between parametric variables.
Results
The volume of the left a‐sHyp hypothalamic subunit was significantly lower in ALS patients than in HCs (p = 0.023, SMD = ‐0.681). No significant correlation was found between the volume of the hypothalamic subunits, body mass index (BMI), and ALSFRS‐R in patients with ALS. However, right a‐sHyp (r = 0.420, p = 0.041) was correlated with disease duration, whereas right supTub (r = −0.471, p = 0.020) and left postHyp (r = −0.406, p = 0.049) were negatively correlated with age. There was no significant difference in the volume of hypothalamic subunits between males and females, and no significant difference was found between patients with revised ALS Functional Rating Scale (ALSFRS‐R) scores ≤41 and >41 and those with a disease duration of 9 months or less.
Discussion and Conclusion
The main finding suggests atrophy of the left a‐sHyp hypothalamic subunit in patients with ALS, which is supported by previous research as an extra‐motor neuroimaging finding for ALS.
This study reveals significant atrophy in the left anterior‐superior hypothalamus of ALS patients compared with healthy controls, highlighting the disease's broader neurological impact beyond motor neuron degeneration.</description><subject>Adult</subject><subject>Aged</subject><subject>ALS</subject><subject>Alzheimer's disease</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - diagnostic imaging</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Atrophy</subject><subject>Automation</subject><subject>Body mass index</subject><subject>Brain research</subject><subject>Female</subject><subject>Humans</subject><subject>Huntingtons disease</subject><subject>Hypothalamus</subject><subject>Hypothalamus (anterior)</subject><subject>Hypothalamus (lateral)</subject><subject>Hypothalamus - diagnostic imaging</subject><subject>Hypothalamus - pathology</subject><subject>Image processing</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Motor neuron diseases</subject><subject>MRI</subject><subject>Neural networks</subject><subject>Neurodegeneration</subject><subject>Neuroimaging</subject><subject>Neurons</subject><subject>Normal distribution</subject><subject>Original</subject><subject>Paralysis</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Physiology</subject><subject>Software</subject><subject>Somatotropin</subject><subject>Statistical analysis</subject><subject>Variables</subject><issn>1755-5930</issn><issn>1755-5949</issn><issn>1755-5949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtuFDEQhi1EREJgwQVQS2zIYiZ2_F6haEQAKYIFj63leMppR267aXeDZpcj5IycBM90MgIk7EWV7K_-eiH0guAlqefUpbIkTGHyCB0RyfmCa6Yf732KD9HTUm4wFmdKqyfokCqlJFHyCLXfcpw6aGIupQmpGdvqgx8bm0YYQh5-3d6Vqd-5TZmuphTGJvsd1276PLY22m7axdpuk8ch921wTbQ13MamuAhDLqE8QwfexgLP7-0x-nrx9svq_eLy07sPq_PLhWOYkAWnwgkvmNWca0woo9ZhrYWlQldDQWqsnOUATGgALrST1irmlVx77zg9Rm9m3X666mDtII21DtMPobPDxmQbzN8_KbTmOv8wdZCKEiGrwut7hSF_n6CMpgvFQYw2QZ6KoVhiqRkjuqKv_kFv8jSk2t-WYkIRyXClljN1bSOYkHydknX1rqELLifwob6fK4wZx2d028PJHODq6MoAfl8-wds6iakbN7uNV_bln_3uyYcVV-B0Bn7WLJv_K5nVx8-z5G_a07e7</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Ghaderi, Sadegh</creator><creator>Fatehi, Farzad</creator><creator>Kalra, Sanjay</creator><creator>Mohammadi, Sana</creator><creator>Zemorshidi, Fariba</creator><creator>Ramezani, Mahtab</creator><creator>Hesami, Omid</creator><creator>Pezeshgi, Saharnaz</creator><creator>Batouli, Seyed Amir Hossein</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2286-9052</orcidid><orcidid>https://orcid.org/0000-0003-4762-8746</orcidid><orcidid>https://orcid.org/0000-0002-1148-3998</orcidid><orcidid>https://orcid.org/0000-0002-6774-7825</orcidid><orcidid>https://orcid.org/0000-0001-7421-3218</orcidid><orcidid>https://orcid.org/0000-0002-9157-4522</orcidid><orcidid>https://orcid.org/0000-0003-4589-5947</orcidid><orcidid>https://orcid.org/0000-0003-1334-8826</orcidid></search><sort><creationdate>202406</creationdate><title>Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis</title><author>Ghaderi, Sadegh ; Fatehi, Farzad ; Kalra, Sanjay ; Mohammadi, Sana ; Zemorshidi, Fariba ; Ramezani, Mahtab ; Hesami, Omid ; Pezeshgi, Saharnaz ; Batouli, Seyed Amir Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4011-536c6f64a955901343ac0996a3699963e7908ca5ee469ee569c7aa84f87dffc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>ALS</topic><topic>Alzheimer's disease</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - diagnostic imaging</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Atrophy</topic><topic>Automation</topic><topic>Body mass index</topic><topic>Brain research</topic><topic>Female</topic><topic>Humans</topic><topic>Huntingtons disease</topic><topic>Hypothalamus</topic><topic>Hypothalamus (anterior)</topic><topic>Hypothalamus (lateral)</topic><topic>Hypothalamus - diagnostic imaging</topic><topic>Hypothalamus - pathology</topic><topic>Image processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Motor neuron diseases</topic><topic>MRI</topic><topic>Neural networks</topic><topic>Neurodegeneration</topic><topic>Neuroimaging</topic><topic>Neurons</topic><topic>Normal distribution</topic><topic>Original</topic><topic>Paralysis</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Physiology</topic><topic>Software</topic><topic>Somatotropin</topic><topic>Statistical analysis</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghaderi, Sadegh</creatorcontrib><creatorcontrib>Fatehi, Farzad</creatorcontrib><creatorcontrib>Kalra, Sanjay</creatorcontrib><creatorcontrib>Mohammadi, Sana</creatorcontrib><creatorcontrib>Zemorshidi, Fariba</creatorcontrib><creatorcontrib>Ramezani, Mahtab</creatorcontrib><creatorcontrib>Hesami, Omid</creatorcontrib><creatorcontrib>Pezeshgi, Saharnaz</creatorcontrib><creatorcontrib>Batouli, Seyed Amir Hossein</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest 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(Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>CNS neuroscience & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghaderi, Sadegh</au><au>Fatehi, Farzad</au><au>Kalra, Sanjay</au><au>Mohammadi, Sana</au><au>Zemorshidi, Fariba</au><au>Ramezani, Mahtab</au><au>Hesami, Omid</au><au>Pezeshgi, Saharnaz</au><au>Batouli, Seyed Amir Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis</atitle><jtitle>CNS neuroscience & therapeutics</jtitle><addtitle>CNS Neurosci Ther</addtitle><date>2024-06</date><risdate>2024</risdate><volume>30</volume><issue>6</issue><spage>e14801</spage><epage>n/a</epage><pages>e14801-n/a</pages><issn>1755-5930</issn><issn>1755-5949</issn><eissn>1755-5949</eissn><abstract>Background and Objective
Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as motor neuron disease (MND), ALS also affects non‐motor regions, such as the hypothalamus. This study aimed to quantify the hypothalamic subregion volumes in patients with ALS versus healthy controls (HCs) and examine their associations with demographic and clinical features.
Methods
Forty‐eight participants (24 ALS patients and 24 HCs) underwent structural MRI. A deep convolutional neural network was used for the automated segmentation of the hypothalamic subunits, including the anterior‐superior (a‐sHyp), anterior‐inferior (a‐iHyp), superior tuberal (supTub), inferior tuberal (infTub), and posterior (posHyp). The neural network was validated using FreeSurfer v7.4.1, with individual head size variations normalized using total intracranial volume (TIV) normalization. Statistical analyses were performed for comparisons using independent sample t‐tests. Correlations were calculated using Pearson's and Spearman's tests (p < 0.05). The standard mean difference (SMD) was used to compare the mean differences between parametric variables.
Results
The volume of the left a‐sHyp hypothalamic subunit was significantly lower in ALS patients than in HCs (p = 0.023, SMD = ‐0.681). No significant correlation was found between the volume of the hypothalamic subunits, body mass index (BMI), and ALSFRS‐R in patients with ALS. However, right a‐sHyp (r = 0.420, p = 0.041) was correlated with disease duration, whereas right supTub (r = −0.471, p = 0.020) and left postHyp (r = −0.406, p = 0.049) were negatively correlated with age. There was no significant difference in the volume of hypothalamic subunits between males and females, and no significant difference was found between patients with revised ALS Functional Rating Scale (ALSFRS‐R) scores ≤41 and >41 and those with a disease duration of 9 months or less.
Discussion and Conclusion
The main finding suggests atrophy of the left a‐sHyp hypothalamic subunit in patients with ALS, which is supported by previous research as an extra‐motor neuroimaging finding for ALS.
This study reveals significant atrophy in the left anterior‐superior hypothalamus of ALS patients compared with healthy controls, highlighting the disease's broader neurological impact beyond motor neuron degeneration.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38887187</pmid><doi>10.1111/cns.14801</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2286-9052</orcidid><orcidid>https://orcid.org/0000-0003-4762-8746</orcidid><orcidid>https://orcid.org/0000-0002-1148-3998</orcidid><orcidid>https://orcid.org/0000-0002-6774-7825</orcidid><orcidid>https://orcid.org/0000-0001-7421-3218</orcidid><orcidid>https://orcid.org/0000-0002-9157-4522</orcidid><orcidid>https://orcid.org/0000-0003-4589-5947</orcidid><orcidid>https://orcid.org/0000-0003-1334-8826</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | CNS neuroscience & therapeutics, 2024-06, Vol.30 (6), p.e14801-n/a |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Adult Aged ALS Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnostic imaging Amyotrophic Lateral Sclerosis - pathology Atrophy Automation Body mass index Brain research Female Humans Huntingtons disease Hypothalamus Hypothalamus (anterior) Hypothalamus (lateral) Hypothalamus - diagnostic imaging Hypothalamus - pathology Image processing Magnetic Resonance Imaging Male Metabolism Middle Aged Motor neuron diseases MRI Neural networks Neurodegeneration Neuroimaging Neurons Normal distribution Original Paralysis Parkinson's disease Patients Physiology Software Somatotropin Statistical analysis Variables |
| title | Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis |
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