Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

Background Tregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in peripheral blood (PB)-Tregs isolated from primary RCC patients. Methods PB-Tregs were isolated from 77 RCC patients and 38 healthy donors (HDs). CFSE-T eff...

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Veröffentlicht in:	British journal of cancer 2024-06, Vol.130 (12), p.2016-2026
Hauptverfasser:	Santagata, Sara, Rea, Giuseppina, Bello, Anna Maria, Capiluongo, Anna, Napolitano, Maria, Desicato, Sonia, Fragale, Alessandra, D’Alterio, Crescenzo, Trotta, Anna Maria, Ieranò, Caterina, Portella, Luigi, Persico, Francesco, Di Napoli, Marilena, Di Maro, Salvatore, Feroce, Florinda, Azzaro, Rosa, Gabriele, Lucia, Longo, Nicola, Pignata, Sandro, Perdonà, Sisto, Scala, Stefania
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/67 631/67/589/1588 AKT protein Biomedical and Life Sciences Biomedicine Cancer Research CD25 antigen CD40L protein Cell growth CTLA-4 protein CXCL12 protein CXCR4 protein Demethylation DNA methylation DNMT1 protein Drug Resistance Epidemiology Foxp3 protein Interleukin 10 Kidney cancer Laboratories Ligands Lymphocytes Lymphocytes T Methylation Molecular Medicine Oncology Ovarian cancer PD-1 protein Peripheral blood PTEN protein Renal cell carcinoma Renal function Signal transduction Transforming growth factor-b1 Tumor microenvironment Urology γ-Interferon
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