DIPG-70. NQO1 AS A RESISTANCE DRIVER AND THERAPEUTIC TARGET IN DMG

p53 pathway reactivation through pharmacologic inhibition of negative regulators was identified as a promising therapeutic strategy for TP53 wild-type (WT) high-grade gliomas, including Diffuse Midline Gliomas (DMGs). Despite widespread theoretical promise, the therapeutic efficacy of MDM2 inhibitor...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2024-06, Vol.26 (Supplement_4), p.0-0
Hauptverfasser:	Lupien, Leslie E, Morin, Eric, Zhang, Daren F, Novikov, Dana R, Chacon, Madison S, Khuu, Nicholas, Keshishian, Hasmik, Seidel, Olivia, Carr, Steven A, Goodale, Amy, Persky, Nicole S, Root, David E, Cusick, Margaret, Ligon, Keith L, Beroukhim, Rameen, Phoenix, Timothy M, Rendo, Veronica, Bandopadhayay, Pratiti
Format:	Artikel
Sprache:	eng
Schlagworte:	Final category: Diffuse Midline Glioma, Diffuse Intrinsic Pontine Glioma
Online-Zugang:	Volltext
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