Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance

Synapse maintenance is essential for generating functional circuitry, and decrement in this process is a hallmark of neurodegenerative disease. Yet, little is known about synapse maintenance in vivo. Cysteine string protein α (CSPα), encoded by the gene, is a synaptic vesicle chaperone that is neces...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-06, Vol.121 (24), p.e2320064121
Hauptverfasser:	Wang, Na, Zhu, Biqing, Allnutt, Mary Alice, Grijalva, Rosalie M, Zhao, Hongyu, Chandra, Sreeganga S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Biological Sciences Cell activation Cell interactions Circuits Cysteine Electron microscopy Functional anatomy Gene expression Glial cells HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Maintenance Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Microglia Neurodegeneration Neurodegenerative diseases Neuroglia Neuroglia - metabolism Neuronal-glial interactions Neurons Neurons - metabolism Phagosomes Proteins Signatures String protein Strings Synapses Synapses - metabolism Transcriptome Transcriptomics
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