Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment

INTRODUCTION Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of Alzheimer's disease (AD). METHODS Ten cognitivel...

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Veröffentlicht in:	Alzheimer's & dementia 2024-06, Vol.20 (6), p.3876-3888
Hauptverfasser:	Wang, Jie, Huang, Qi, He, Kun, Li, Junpeng, Guo, Tengfei, Yang, Yang, Lin, Zengping, Li, Songye, Vanderlinden, Greet, Huang, Yiyun, Van Laere, Koen, Guan, Yihui, Guo, Qihao, Ni, Ruiqing, Li, Binying, Xie, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease amyloid deposition cognition mGluR5 availability PET/MR synaptic density
Online-Zugang:	Volltext
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