Molecular epidemiological and clinical infection characteristics analysis of Ralstonia
Purpose This study was to clarify the molecular epidemiology and clinical infection characteristics of Ralstonia pickettii and establish sequence typing system. Methods 48 nonrepetitive Ralstonia pickettii strains were collected from January 2008 to December 2013 at the Chinese People’s Liberation A...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2024-06, Vol.43 (6), p.1161-1170 |
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| creator | Sheng, Zhaojun Li, Jiaxin Han, Guojing Fan, Ru Zhu, Pingjun Fang, Xiangqun |
| description | Purpose
This study was to clarify the molecular epidemiology and clinical infection characteristics of
Ralstonia pickettii
and establish sequence typing system.
Methods
48 nonrepetitive
Ralstonia pickettii
strains were collected from January 2008 to December 2013 at the Chinese People’s Liberation Army General Hospital (PLAGH) and were identified through a specific PCR experiment, 16 S rDNA experiment and VITEK 2 system to compare the identification accuracy. The sequence types of the strains were analyzed by multilocus sequence typing (MLST) method. The antibiotic sensitivity of these strains was determined with disc diffusion tests and broth microdilution method. The clinical data of
Ralstonia pickettii
infected patients were collected.
Results
All of the 48 strains were identified as
Ralstonia pickettii
by VITEK 2 system. 30 and 34 strains were identified as
Ralstonia pickettii
by PCR and 16 S rDNA experiment respectively. ST9 was the most sequence types (STs) in these 18 STs of 42 strains. 42 strains were divided into 2 groups (A and B) and 18 genotypes.
Ralstonia pickettii
was sensitive to some cephalosporins, β-lactam/β-lactamase inhibitor, levofloxacin and trimethoprim/sulfamethoxazole. Cough, sputum, shortness of breath and pulmonary rales were the common clinical symptoms of most
Ralstonia pickettii
infected patients.
Conclusion
We established a sequence typing system with a relatively fine resolution and the PCR assay is a faster and more sensitive method for clinical identification of
Ralstonia pickettii
. ST9 is the most common sequence types of
Ralstonia pickettii
. The most common clinical characteristics of
Ralstonia pickettii
infected patients were cough, sputum, shortness of breath and pulmonary rales. |
| doi_str_mv | 10.1007/s10096-024-04823-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11178629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3043072996</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-87a49a0eed60771b92c56a179e024fa8213ead5ebefc2be495b094ebc9ba47f43</originalsourceid><addsrcrecordid>eNp9kUtP3DAUha2qVZnS_gEWKFI3bNL6ldheIYToQ6KqVEG31o1zMxh57KmdgPj3NQylj0U3fuh-59hHh5ADRt8xStX7UlfTt5TLlkrNRXv7jKyYFF0rhRLPyYoaIVujuNgjr0q5plWklXpJ9oTuhdEdXZHvX1JAtwTIDW79iBufQlp7B6GBODYu-Phw8XFCN_sUG3cFGdyM2ZfZu1IxCHfFlyZNzTcIZU7Rw2vyYqpnfPO475PLD2cXp5_a868fP5-enLdO8n5utQJpgCKOPVWKDYa7rgemDNZQE2jOBMLY4YCT4wNK0w3USBycGUCqSYp9crzz3S7DBkeHcc4Q7Db7DeQ7m8DbvyfRX9l1urGMMaV7bqrD0aNDTj8WLLPd-OIwBIiYlmIFlYIqbkxf0bf_oNdpyTX-PdXXArQ0ulJ8R7mcSsk4Pf2GUXvfm931ZmtE-9Cbva2iwz9zPEl-FVUBsQNKHcU15t9v_8f2J5fLpoU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3068238498</pqid></control><display><type>article</type><title>Molecular epidemiological and clinical infection characteristics analysis of Ralstonia</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Sheng, Zhaojun ; Li, Jiaxin ; Han, Guojing ; Fan, Ru ; Zhu, Pingjun ; Fang, Xiangqun</creator><creatorcontrib>Sheng, Zhaojun ; Li, Jiaxin ; Han, Guojing ; Fan, Ru ; Zhu, Pingjun ; Fang, Xiangqun</creatorcontrib><description>Purpose
This study was to clarify the molecular epidemiology and clinical infection characteristics of
Ralstonia pickettii
and establish sequence typing system.
Methods
48 nonrepetitive
Ralstonia pickettii
strains were collected from January 2008 to December 2013 at the Chinese People’s Liberation Army General Hospital (PLAGH) and were identified through a specific PCR experiment, 16 S rDNA experiment and VITEK 2 system to compare the identification accuracy. The sequence types of the strains were analyzed by multilocus sequence typing (MLST) method. The antibiotic sensitivity of these strains was determined with disc diffusion tests and broth microdilution method. The clinical data of
Ralstonia pickettii
infected patients were collected.
Results
All of the 48 strains were identified as
Ralstonia pickettii
by VITEK 2 system. 30 and 34 strains were identified as
Ralstonia pickettii
by PCR and 16 S rDNA experiment respectively. ST9 was the most sequence types (STs) in these 18 STs of 42 strains. 42 strains were divided into 2 groups (A and B) and 18 genotypes.
Ralstonia pickettii
was sensitive to some cephalosporins, β-lactam/β-lactamase inhibitor, levofloxacin and trimethoprim/sulfamethoxazole. Cough, sputum, shortness of breath and pulmonary rales were the common clinical symptoms of most
Ralstonia pickettii
infected patients.
Conclusion
We established a sequence typing system with a relatively fine resolution and the PCR assay is a faster and more sensitive method for clinical identification of
Ralstonia pickettii
. ST9 is the most common sequence types of
Ralstonia pickettii
. The most common clinical characteristics of
Ralstonia pickettii
infected patients were cough, sputum, shortness of breath and pulmonary rales.</description><identifier>ISSN: 0934-9723</identifier><identifier>ISSN: 1435-4373</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-024-04823-w</identifier><identifier>PMID: 38639850</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Amides ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Biomedical and Life Sciences ; Biomedicine ; Cephalosporins ; China - epidemiology ; Cough ; Diffusion tests ; DNA, Bacterial - genetics ; DNA, Ribosomal - genetics ; Dyspnea ; Epidemiology ; Female ; Genotype ; Genotypes ; Gram-Negative Bacterial Infections - epidemiology ; Gram-Negative Bacterial Infections - microbiology ; Humans ; Internal Medicine ; Levofloxacin ; Male ; Medical Microbiology ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Epidemiology ; Multilocus Sequence Typing ; Original ; Original Article ; Patients ; Polymerase Chain Reaction ; Ralstonia pickettii ; Ralstonia pickettii - genetics ; Ralstonia pickettii - isolation & purification ; RNA, Ribosomal, 16S - genetics ; Soil bacteria ; Sputum ; Strains (organisms) ; Sulfamethoxazole ; Trimethoprim ; Young Adult ; β Lactamase ; β-Lactam antibiotics</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2024-06, Vol.43 (6), p.1161-1170</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-87a49a0eed60771b92c56a179e024fa8213ead5ebefc2be495b094ebc9ba47f43</cites><orcidid>0000-0002-9687-9683</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-024-04823-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-024-04823-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38639850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheng, Zhaojun</creatorcontrib><creatorcontrib>Li, Jiaxin</creatorcontrib><creatorcontrib>Han, Guojing</creatorcontrib><creatorcontrib>Fan, Ru</creatorcontrib><creatorcontrib>Zhu, Pingjun</creatorcontrib><creatorcontrib>Fang, Xiangqun</creatorcontrib><title>Molecular epidemiological and clinical infection characteristics analysis of Ralstonia</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Purpose
This study was to clarify the molecular epidemiology and clinical infection characteristics of
Ralstonia pickettii
and establish sequence typing system.
Methods
48 nonrepetitive
Ralstonia pickettii
strains were collected from January 2008 to December 2013 at the Chinese People’s Liberation Army General Hospital (PLAGH) and were identified through a specific PCR experiment, 16 S rDNA experiment and VITEK 2 system to compare the identification accuracy. The sequence types of the strains were analyzed by multilocus sequence typing (MLST) method. The antibiotic sensitivity of these strains was determined with disc diffusion tests and broth microdilution method. The clinical data of
Ralstonia pickettii
infected patients were collected.
Results
All of the 48 strains were identified as
Ralstonia pickettii
by VITEK 2 system. 30 and 34 strains were identified as
Ralstonia pickettii
by PCR and 16 S rDNA experiment respectively. ST9 was the most sequence types (STs) in these 18 STs of 42 strains. 42 strains were divided into 2 groups (A and B) and 18 genotypes.
Ralstonia pickettii
was sensitive to some cephalosporins, β-lactam/β-lactamase inhibitor, levofloxacin and trimethoprim/sulfamethoxazole. Cough, sputum, shortness of breath and pulmonary rales were the common clinical symptoms of most
Ralstonia pickettii
infected patients.
Conclusion
We established a sequence typing system with a relatively fine resolution and the PCR assay is a faster and more sensitive method for clinical identification of
Ralstonia pickettii
. ST9 is the most common sequence types of
Ralstonia pickettii
. The most common clinical characteristics of
Ralstonia pickettii
infected patients were cough, sputum, shortness of breath and pulmonary rales.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amides</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cephalosporins</subject><subject>China - epidemiology</subject><subject>Cough</subject><subject>Diffusion tests</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Ribosomal - genetics</subject><subject>Dyspnea</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Gram-Negative Bacterial Infections - epidemiology</subject><subject>Gram-Negative Bacterial Infections - microbiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Levofloxacin</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Multilocus Sequence Typing</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Polymerase Chain Reaction</subject><subject>Ralstonia pickettii</subject><subject>Ralstonia pickettii - genetics</subject><subject>Ralstonia pickettii - isolation & purification</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Soil bacteria</subject><subject>Sputum</subject><subject>Strains (organisms)</subject><subject>Sulfamethoxazole</subject><subject>Trimethoprim</subject><subject>Young Adult</subject><subject>β Lactamase</subject><subject>β-Lactam antibiotics</subject><issn>0934-9723</issn><issn>1435-4373</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtP3DAUha2qVZnS_gEWKFI3bNL6ldheIYToQ6KqVEG31o1zMxh57KmdgPj3NQylj0U3fuh-59hHh5ADRt8xStX7UlfTt5TLlkrNRXv7jKyYFF0rhRLPyYoaIVujuNgjr0q5plWklXpJ9oTuhdEdXZHvX1JAtwTIDW79iBufQlp7B6GBODYu-Phw8XFCN_sUG3cFGdyM2ZfZu1IxCHfFlyZNzTcIZU7Rw2vyYqpnfPO475PLD2cXp5_a868fP5-enLdO8n5utQJpgCKOPVWKDYa7rgemDNZQE2jOBMLY4YCT4wNK0w3USBycGUCqSYp9crzz3S7DBkeHcc4Q7Db7DeQ7m8DbvyfRX9l1urGMMaV7bqrD0aNDTj8WLLPd-OIwBIiYlmIFlYIqbkxf0bf_oNdpyTX-PdXXArQ0ulJ8R7mcSsk4Pf2GUXvfm931ZmtE-9Cbva2iwz9zPEl-FVUBsQNKHcU15t9v_8f2J5fLpoU</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Sheng, Zhaojun</creator><creator>Li, Jiaxin</creator><creator>Han, Guojing</creator><creator>Fan, Ru</creator><creator>Zhu, Pingjun</creator><creator>Fang, Xiangqun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9687-9683</orcidid></search><sort><creationdate>20240601</creationdate><title>Molecular epidemiological and clinical infection characteristics analysis of Ralstonia</title><author>Sheng, Zhaojun ; Li, Jiaxin ; Han, Guojing ; Fan, Ru ; Zhu, Pingjun ; Fang, Xiangqun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-87a49a0eed60771b92c56a179e024fa8213ead5ebefc2be495b094ebc9ba47f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Amides</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cephalosporins</topic><topic>China - epidemiology</topic><topic>Cough</topic><topic>Diffusion tests</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Ribosomal - genetics</topic><topic>Dyspnea</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Gram-Negative Bacterial Infections - epidemiology</topic><topic>Gram-Negative Bacterial Infections - microbiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Levofloxacin</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Multilocus Sequence Typing</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Polymerase Chain Reaction</topic><topic>Ralstonia pickettii</topic><topic>Ralstonia pickettii - genetics</topic><topic>Ralstonia pickettii - isolation & purification</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Soil bacteria</topic><topic>Sputum</topic><topic>Strains (organisms)</topic><topic>Sulfamethoxazole</topic><topic>Trimethoprim</topic><topic>Young Adult</topic><topic>β Lactamase</topic><topic>β-Lactam antibiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheng, Zhaojun</creatorcontrib><creatorcontrib>Li, Jiaxin</creatorcontrib><creatorcontrib>Han, Guojing</creatorcontrib><creatorcontrib>Fan, Ru</creatorcontrib><creatorcontrib>Zhu, Pingjun</creatorcontrib><creatorcontrib>Fang, Xiangqun</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheng, Zhaojun</au><au>Li, Jiaxin</au><au>Han, Guojing</au><au>Fan, Ru</au><au>Zhu, Pingjun</au><au>Fang, Xiangqun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular epidemiological and clinical infection characteristics analysis of Ralstonia</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>43</volume><issue>6</issue><spage>1161</spage><epage>1170</epage><pages>1161-1170</pages><issn>0934-9723</issn><issn>1435-4373</issn><eissn>1435-4373</eissn><abstract>Purpose
This study was to clarify the molecular epidemiology and clinical infection characteristics of
Ralstonia pickettii
and establish sequence typing system.
Methods
48 nonrepetitive
Ralstonia pickettii
strains were collected from January 2008 to December 2013 at the Chinese People’s Liberation Army General Hospital (PLAGH) and were identified through a specific PCR experiment, 16 S rDNA experiment and VITEK 2 system to compare the identification accuracy. The sequence types of the strains were analyzed by multilocus sequence typing (MLST) method. The antibiotic sensitivity of these strains was determined with disc diffusion tests and broth microdilution method. The clinical data of
Ralstonia pickettii
infected patients were collected.
Results
All of the 48 strains were identified as
Ralstonia pickettii
by VITEK 2 system. 30 and 34 strains were identified as
Ralstonia pickettii
by PCR and 16 S rDNA experiment respectively. ST9 was the most sequence types (STs) in these 18 STs of 42 strains. 42 strains were divided into 2 groups (A and B) and 18 genotypes.
Ralstonia pickettii
was sensitive to some cephalosporins, β-lactam/β-lactamase inhibitor, levofloxacin and trimethoprim/sulfamethoxazole. Cough, sputum, shortness of breath and pulmonary rales were the common clinical symptoms of most
Ralstonia pickettii
infected patients.
Conclusion
We established a sequence typing system with a relatively fine resolution and the PCR assay is a faster and more sensitive method for clinical identification of
Ralstonia pickettii
. ST9 is the most common sequence types of
Ralstonia pickettii
. The most common clinical characteristics of
Ralstonia pickettii
infected patients were cough, sputum, shortness of breath and pulmonary rales.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38639850</pmid><doi>10.1007/s10096-024-04823-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9687-9683</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2024-06, Vol.43 (6), p.1161-1170 |
| issn | 0934-9723 1435-4373 1435-4373 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11178629 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Aged Amides Anti-Bacterial Agents - pharmacology Antibiotics Biomedical and Life Sciences Biomedicine Cephalosporins China - epidemiology Cough Diffusion tests DNA, Bacterial - genetics DNA, Ribosomal - genetics Dyspnea Epidemiology Female Genotype Genotypes Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - microbiology Humans Internal Medicine Levofloxacin Male Medical Microbiology Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Original Original Article Patients Polymerase Chain Reaction Ralstonia pickettii Ralstonia pickettii - genetics Ralstonia pickettii - isolation & purification RNA, Ribosomal, 16S - genetics Soil bacteria Sputum Strains (organisms) Sulfamethoxazole Trimethoprim Young Adult β Lactamase β-Lactam antibiotics |
| title | Molecular epidemiological and clinical infection characteristics analysis of Ralstonia |
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