High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin

Serotonergic psychedelics are emerging therapeutics for psychiatric disorders, yet their underlying mechanisms of action in the brain remain largely elusive. Here, we developed a wide-field behavioral tracking system for larval zebrafish and investigated the effects of psilocybin, a psychedelic sero...

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Veröffentlicht in:	Molecular psychiatry 2024-04, Vol.29 (4), p.1046-1062
Hauptverfasser:	Braun, Dotan, Rosenberg, Ayelet M., Rabaniam, Elad, Haruvi, Ravid, Malamud, Dorel, Barbara, Rani, Aiznkot, Tomer, Levavi-Sivan, Berta, Kawashima, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	101/47 13/51 631/154 631/378 631/443 64 64/116 96/63 Animals Anti-Anxiety Agents - pharmacology Anxiety - drug therapy Behavior, Animal - drug effects Behavioral Sciences Biological Psychology Brain - drug effects Danio rerio Dorsal raphe nucleus Dorsal Raphe Nucleus - drug effects Exploration GABAergic Neurons - drug effects Hallucinogens - pharmacology Immediate Communication Ketamine Ketamine - pharmacology Kinematics Larva - drug effects Medicine Medicine & Public Health Mental disorders Neuroimaging Neurons Neurosciences Pharmacotherapy Psilocybin Psilocybin - pharmacology Psychedelic drugs Psychiatry Raphe nuclei Selective Serotonin Reuptake Inhibitors - pharmacology Serotonergic Neurons - drug effects Serotonin Receptor Agonists - pharmacology Serotonin uptake inhibitors Swimming Zebrafish γ-Aminobutyric acid
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