Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five...
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| Veröffentlicht in: | Molecular psychiatry 2024-04, Vol.29 (4), p.1033-1045 |
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| creator | Vriend, Chris de Joode, Niels T. Pouwels, Petra J. W. Liu, Feng Otaduy, Maria C. G. Pastorello, Bruno Robertson, Frances C. Ipser, Jonathan Lee, Seonjoo Hezel, Dianne M. van Meter, Page E. Batistuzzo, Marcelo C. Hoexter, Marcelo Q. Sheshachala, Karthik Narayanaswamy, Janardhanan C. Venkatasubramanian, Ganesan Lochner, Christine Miguel, Euripedes C. Reddy, Y. C. Janardhan Shavitt, Roseli G. Stein, Dan J. Wall, Melanie Simpson, Helen Blair van den Heuvel, Odile A. |
| description | Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early ( |
| doi_str_mv | 10.1038/s41380-023-02390-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11176057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2915990444</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-aefac2d382e5c92351e4a83d7c911fe5e908e205cfb9de1bd3f84e20591d23153</originalsourceid><addsrcrecordid>eNp9UU1PGzEUtFBRgbR_oIdqpV64LPgza58qFJUPKRIXOBvH-xyMdtep7aXKv8dLKJQeOFge-80bz_Mg9I3gE4KZPE2cMIlrTNm0FK7lHjokvJnXQjTyU8FMqJoTyQ_QUUoPGE9F8RkdMEmplAoforuzNVTBVWFIkJ_BKkFK_hFqG_rN2E2wan0KsYVYgHMQYcjedN22MuVkc6r-3PsMVW9yLpze2xhSjqPNY4QvaN-ZLsHXl32Gbs9_3Swu6-X1xdXibFlb3ohcG3DG0rYYA2EVZYIAN5K1jVWEOBCgsASKhXUr1QJZtcxJPl0o0lJGBJuhnzvdzbjqobXFYzSd3kTfm7jVwXj9vjL4e70Oj5oQ0syxaIrC8YtCDL9HSFn3PlnoOjNAGJOmigilMOe8UH_8R30IYxzKfJrheSPmxZEsLLpjTf-RIrhXNwTrKUG9S1CX9PRzgnpq-v7vHK8tfyMrBLYjpFIa1hDf3v5A9gm6IKl0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3067563158</pqid></control><display><type>article</type><title>Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure</title><source>Springer Nature - Complete Springer Journals</source><creator>Vriend, Chris ; de Joode, Niels T. ; Pouwels, Petra J. W. ; Liu, Feng ; Otaduy, Maria C. G. ; Pastorello, Bruno ; Robertson, Frances C. ; Ipser, Jonathan ; Lee, Seonjoo ; Hezel, Dianne M. ; van Meter, Page E. ; Batistuzzo, Marcelo C. ; Hoexter, Marcelo Q. ; Sheshachala, Karthik ; Narayanaswamy, Janardhanan C. ; Venkatasubramanian, Ganesan ; Lochner, Christine ; Miguel, Euripedes C. ; Reddy, Y. C. Janardhan ; Shavitt, Roseli G. ; Stein, Dan J. ; Wall, Melanie ; Simpson, Helen Blair ; van den Heuvel, Odile A.</creator><creatorcontrib>Vriend, Chris ; de Joode, Niels T. ; Pouwels, Petra J. W. ; Liu, Feng ; Otaduy, Maria C. G. ; Pastorello, Bruno ; Robertson, Frances C. ; Ipser, Jonathan ; Lee, Seonjoo ; Hezel, Dianne M. ; van Meter, Page E. ; Batistuzzo, Marcelo C. ; Hoexter, Marcelo Q. ; Sheshachala, Karthik ; Narayanaswamy, Janardhanan C. ; Venkatasubramanian, Ganesan ; Lochner, Christine ; Miguel, Euripedes C. ; Reddy, Y. C. Janardhan ; Shavitt, Roseli G. ; Stein, Dan J. ; Wall, Melanie ; Simpson, Helen Blair ; van den Heuvel, Odile A.</creatorcontrib><description>Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early (<18) versus late (18+) OCD onset using mixed-model and Bayesian multilevel analysis. Compared with healthy controls, adult OCD individuals showed higher fiber density in the sagittal stratum (
B[SE]
= 0.10[0.05],
P
= 0.04) and credible evidence for higher fiber density in several other tracts. When comparing early (
n
= 145) and late-onset (
n
= 114) cases, converging evidence showed lower integrity of the posterior thalamic radiation —particularly radial diffusivity (
B[SE]
= 0.28[0.12],
P
= 0.03)—and lower global efficiency of the structural connectome (
B[SE]
= 15.3[6.6],
P
= 0.03) in late-onset cases. Post-hoc analyses indicated divergent direction of effects of the two OCD groups compared to healthy controls. Age of OCD onset differentially affects the integrity of thalamo-parietal/occipital tracts and the efficiency of the structural brain network. These results lend further support for the role of the thalamus and its afferent fibers and visual attentional processes in the pathophysiology of OCD.</description><identifier>ISSN: 1359-4184</identifier><identifier>ISSN: 1476-5578</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-023-02390-8</identifier><identifier>PMID: 38228890</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/378 ; 692/699/476 ; Anisotropy ; Bayesian analysis ; Behavioral Sciences ; Biological Psychology ; Medicine ; Medicine & Public Health ; Neuroimaging ; Neurosciences ; Neuroses ; Obsessive compulsive disorder ; Orientation behavior ; Pharmacotherapy ; Psychiatry ; Sensory neurons ; Substantia alba ; Thalamus ; Visual pathways</subject><ispartof>Molecular psychiatry, 2024-04, Vol.29 (4), p.1033-1045</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-aefac2d382e5c92351e4a83d7c911fe5e908e205cfb9de1bd3f84e20591d23153</citedby><cites>FETCH-LOGICAL-c475t-aefac2d382e5c92351e4a83d7c911fe5e908e205cfb9de1bd3f84e20591d23153</cites><orcidid>0000-0002-2097-2283 ; 0000-0003-2515-1131 ; 0000-0001-7218-7810 ; 0000-0001-8430-0606 ; 0000-0002-9393-3103 ; 0000-0002-9804-7653 ; 0000-0002-4766-3704 ; 0000-0002-0949-898X ; 0000-0003-1347-8241 ; 0000-0003-3111-1304</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-023-02390-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-023-02390-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38228890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vriend, Chris</creatorcontrib><creatorcontrib>de Joode, Niels T.</creatorcontrib><creatorcontrib>Pouwels, Petra J. W.</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Otaduy, Maria C. G.</creatorcontrib><creatorcontrib>Pastorello, Bruno</creatorcontrib><creatorcontrib>Robertson, Frances C.</creatorcontrib><creatorcontrib>Ipser, Jonathan</creatorcontrib><creatorcontrib>Lee, Seonjoo</creatorcontrib><creatorcontrib>Hezel, Dianne M.</creatorcontrib><creatorcontrib>van Meter, Page E.</creatorcontrib><creatorcontrib>Batistuzzo, Marcelo C.</creatorcontrib><creatorcontrib>Hoexter, Marcelo Q.</creatorcontrib><creatorcontrib>Sheshachala, Karthik</creatorcontrib><creatorcontrib>Narayanaswamy, Janardhanan C.</creatorcontrib><creatorcontrib>Venkatasubramanian, Ganesan</creatorcontrib><creatorcontrib>Lochner, Christine</creatorcontrib><creatorcontrib>Miguel, Euripedes C.</creatorcontrib><creatorcontrib>Reddy, Y. C. Janardhan</creatorcontrib><creatorcontrib>Shavitt, Roseli G.</creatorcontrib><creatorcontrib>Stein, Dan J.</creatorcontrib><creatorcontrib>Wall, Melanie</creatorcontrib><creatorcontrib>Simpson, Helen Blair</creatorcontrib><creatorcontrib>van den Heuvel, Odile A.</creatorcontrib><title>Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early (<18) versus late (18+) OCD onset using mixed-model and Bayesian multilevel analysis. Compared with healthy controls, adult OCD individuals showed higher fiber density in the sagittal stratum (
B[SE]
= 0.10[0.05],
P
= 0.04) and credible evidence for higher fiber density in several other tracts. When comparing early (
n
= 145) and late-onset (
n
= 114) cases, converging evidence showed lower integrity of the posterior thalamic radiation —particularly radial diffusivity (
B[SE]
= 0.28[0.12],
P
= 0.03)—and lower global efficiency of the structural connectome (
B[SE]
= 15.3[6.6],
P
= 0.03) in late-onset cases. Post-hoc analyses indicated divergent direction of effects of the two OCD groups compared to healthy controls. Age of OCD onset differentially affects the integrity of thalamo-parietal/occipital tracts and the efficiency of the structural brain network. These results lend further support for the role of the thalamus and its afferent fibers and visual attentional processes in the pathophysiology of OCD.</description><subject>59/57</subject><subject>631/378</subject><subject>692/699/476</subject><subject>Anisotropy</subject><subject>Bayesian analysis</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Neuroses</subject><subject>Obsessive compulsive disorder</subject><subject>Orientation behavior</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Sensory neurons</subject><subject>Substantia alba</subject><subject>Thalamus</subject><subject>Visual pathways</subject><issn>1359-4184</issn><issn>1476-5578</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9UU1PGzEUtFBRgbR_oIdqpV64LPgza58qFJUPKRIXOBvH-xyMdtep7aXKv8dLKJQeOFge-80bz_Mg9I3gE4KZPE2cMIlrTNm0FK7lHjokvJnXQjTyU8FMqJoTyQ_QUUoPGE9F8RkdMEmplAoforuzNVTBVWFIkJ_BKkFK_hFqG_rN2E2wan0KsYVYgHMQYcjedN22MuVkc6r-3PsMVW9yLpze2xhSjqPNY4QvaN-ZLsHXl32Gbs9_3Swu6-X1xdXibFlb3ohcG3DG0rYYA2EVZYIAN5K1jVWEOBCgsASKhXUr1QJZtcxJPl0o0lJGBJuhnzvdzbjqobXFYzSd3kTfm7jVwXj9vjL4e70Oj5oQ0syxaIrC8YtCDL9HSFn3PlnoOjNAGJOmigilMOe8UH_8R30IYxzKfJrheSPmxZEsLLpjTf-RIrhXNwTrKUG9S1CX9PRzgnpq-v7vHK8tfyMrBLYjpFIa1hDf3v5A9gm6IKl0</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Vriend, Chris</creator><creator>de Joode, Niels T.</creator><creator>Pouwels, Petra J. 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G.</au><au>Pastorello, Bruno</au><au>Robertson, Frances C.</au><au>Ipser, Jonathan</au><au>Lee, Seonjoo</au><au>Hezel, Dianne M.</au><au>van Meter, Page E.</au><au>Batistuzzo, Marcelo C.</au><au>Hoexter, Marcelo Q.</au><au>Sheshachala, Karthik</au><au>Narayanaswamy, Janardhanan C.</au><au>Venkatasubramanian, Ganesan</au><au>Lochner, Christine</au><au>Miguel, Euripedes C.</au><au>Reddy, Y. C. Janardhan</au><au>Shavitt, Roseli G.</au><au>Stein, Dan J.</au><au>Wall, Melanie</au><au>Simpson, Helen Blair</au><au>van den Heuvel, Odile A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>29</volume><issue>4</issue><spage>1033</spage><epage>1045</epage><pages>1033-1045</pages><issn>1359-4184</issn><issn>1476-5578</issn><eissn>1476-5578</eissn><abstract>Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early (<18) versus late (18+) OCD onset using mixed-model and Bayesian multilevel analysis. Compared with healthy controls, adult OCD individuals showed higher fiber density in the sagittal stratum (
B[SE]
= 0.10[0.05],
P
= 0.04) and credible evidence for higher fiber density in several other tracts. When comparing early (
n
= 145) and late-onset (
n
= 114) cases, converging evidence showed lower integrity of the posterior thalamic radiation —particularly radial diffusivity (
B[SE]
= 0.28[0.12],
P
= 0.03)—and lower global efficiency of the structural connectome (
B[SE]
= 15.3[6.6],
P
= 0.03) in late-onset cases. Post-hoc analyses indicated divergent direction of effects of the two OCD groups compared to healthy controls. Age of OCD onset differentially affects the integrity of thalamo-parietal/occipital tracts and the efficiency of the structural brain network. These results lend further support for the role of the thalamus and its afferent fibers and visual attentional processes in the pathophysiology of OCD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38228890</pmid><doi>10.1038/s41380-023-02390-8</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2097-2283</orcidid><orcidid>https://orcid.org/0000-0003-2515-1131</orcidid><orcidid>https://orcid.org/0000-0001-7218-7810</orcidid><orcidid>https://orcid.org/0000-0001-8430-0606</orcidid><orcidid>https://orcid.org/0000-0002-9393-3103</orcidid><orcidid>https://orcid.org/0000-0002-9804-7653</orcidid><orcidid>https://orcid.org/0000-0002-4766-3704</orcidid><orcidid>https://orcid.org/0000-0002-0949-898X</orcidid><orcidid>https://orcid.org/0000-0003-1347-8241</orcidid><orcidid>https://orcid.org/0000-0003-3111-1304</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular psychiatry, 2024-04, Vol.29 (4), p.1033-1045 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | 59/57 631/378 692/699/476 Anisotropy Bayesian analysis Behavioral Sciences Biological Psychology Medicine Medicine & Public Health Neuroimaging Neurosciences Neuroses Obsessive compulsive disorder Orientation behavior Pharmacotherapy Psychiatry Sensory neurons Substantia alba Thalamus Visual pathways |
| title | Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure |
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