Placenta-Related Parameters at Delivery in Relation to Folic Acid Supplementation in Different Pregnancies
Folic acid plays an important role in the synthesis, repair, and methylation of deoxyribonucleic acid (DNA). Currently, most studies have focused on the effects of periconceptional folic acid (FA) supplementation on fetal development, and there is still a lack of population-based research exploring...
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| Veröffentlicht in: | Nutrients 2024-05, Vol.16 (11), p.1729 |
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| creator | Ren, Yating Yang, Maoyuan Ren, Siyi Ge, Zhihao Cao, Yu Qin, Xinsheng Sheng, Jie Wang, Sufang |
| description | Folic acid plays an important role in the synthesis, repair, and methylation of deoxyribonucleic acid (DNA). Currently, most studies have focused on the effects of periconceptional folic acid (FA) supplementation on fetal development, and there is still a lack of population-based research exploring the association between FA use during pregnancy and placental development. This study aimed to investigate the impacts of FA supplementation in different pregnancies on placenta-related parameters at delivery. The study included 2708 pregnant women recruited from Ma'anshan City, Anhui Province, China, between May 2013 and September 2014. Information on FA use from one month before conception to delivery was collected. Placental length, width, and thickness were measured. Multivariable logistic regression analysis was used to assess the effects of FA supplementation in different pregnancies on placenta-related parameters. Based on multiple regression analysis, propensity score weighting was adopted to enhance comparability between different FA supplementation groups. Compared with FA non-users, FA supplementation before conception was associated with increased placental width (0.241 cm, 95%CI: 0.052-0.429,
= 0.013) and increased placental surface area (6.398 cm
, 95%CI: 1.407-11.389,
= 0.012), and FA use in early/middle pregnancy was, respectively, related with increased placental thickness (0.061 cm, 95%CI: 0.004-0.117,
= 0.036; 0.066 cm, 95%CI: 0.004-0.129,
= 0.038). FA use before conception could increase placental width and area, and FA use in early/middle pregnancy could increase placental thickness. To confirm the findings, further investigations are needed. |
| doi_str_mv | 10.3390/nu16111729 |
| format | Article |
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= 0.013) and increased placental surface area (6.398 cm
, 95%CI: 1.407-11.389,
= 0.012), and FA use in early/middle pregnancy was, respectively, related with increased placental thickness (0.061 cm, 95%CI: 0.004-0.117,
= 0.036; 0.066 cm, 95%CI: 0.004-0.129,
= 0.038). FA use before conception could increase placental width and area, and FA use in early/middle pregnancy could increase placental thickness. To confirm the findings, further investigations are needed.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16111729</identifier><identifier>PMID: 38892661</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Birth weight ; Blood pressure ; Blood vessels ; Body mass index ; Carbon ; Cell division ; China ; Delivery, Obstetric - methods ; Diabetes ; Dietary Supplements ; DNA binding proteins ; DNA methylation ; Female ; Fetuses ; Folic acid ; Folic Acid - administration & dosage ; Gene expression ; Genes ; Histones ; Homocysteine ; Humans ; Maternal & child health ; Metabolism ; Methylation ; Physiological aspects ; Placenta ; Placenta - drug effects ; Placentation - drug effects ; Pregnancy ; Pregnant women ; Questionnaires ; Regression analysis ; Variables ; Variance analysis ; Vitamin B ; Womens health ; Young Adult</subject><ispartof>Nutrients, 2024-05, Vol.16 (11), p.1729</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c363t-71d3be188f5dca6d2540e3094e86f8e89d5a16edfdb9d4a490252a793d025cf3</cites><orcidid>0009-0008-6794-2947</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11174953/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11174953/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38892661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Yating</creatorcontrib><creatorcontrib>Yang, Maoyuan</creatorcontrib><creatorcontrib>Ren, Siyi</creatorcontrib><creatorcontrib>Ge, Zhihao</creatorcontrib><creatorcontrib>Cao, Yu</creatorcontrib><creatorcontrib>Qin, Xinsheng</creatorcontrib><creatorcontrib>Sheng, Jie</creatorcontrib><creatorcontrib>Wang, Sufang</creatorcontrib><title>Placenta-Related Parameters at Delivery in Relation to Folic Acid Supplementation in Different Pregnancies</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Folic acid plays an important role in the synthesis, repair, and methylation of deoxyribonucleic acid (DNA). Currently, most studies have focused on the effects of periconceptional folic acid (FA) supplementation on fetal development, and there is still a lack of population-based research exploring the association between FA use during pregnancy and placental development. This study aimed to investigate the impacts of FA supplementation in different pregnancies on placenta-related parameters at delivery. The study included 2708 pregnant women recruited from Ma'anshan City, Anhui Province, China, between May 2013 and September 2014. Information on FA use from one month before conception to delivery was collected. Placental length, width, and thickness were measured. Multivariable logistic regression analysis was used to assess the effects of FA supplementation in different pregnancies on placenta-related parameters. Based on multiple regression analysis, propensity score weighting was adopted to enhance comparability between different FA supplementation groups. Compared with FA non-users, FA supplementation before conception was associated with increased placental width (0.241 cm, 95%CI: 0.052-0.429,
= 0.013) and increased placental surface area (6.398 cm
, 95%CI: 1.407-11.389,
= 0.012), and FA use in early/middle pregnancy was, respectively, related with increased placental thickness (0.061 cm, 95%CI: 0.004-0.117,
= 0.036; 0.066 cm, 95%CI: 0.004-0.129,
= 0.038). FA use before conception could increase placental width and area, and FA use in early/middle pregnancy could increase placental thickness. To confirm the findings, further investigations are needed.</description><subject>Adult</subject><subject>Birth weight</subject><subject>Blood pressure</subject><subject>Blood vessels</subject><subject>Body mass index</subject><subject>Carbon</subject><subject>Cell division</subject><subject>China</subject><subject>Delivery, Obstetric - methods</subject><subject>Diabetes</subject><subject>Dietary Supplements</subject><subject>DNA binding proteins</subject><subject>DNA methylation</subject><subject>Female</subject><subject>Fetuses</subject><subject>Folic acid</subject><subject>Folic Acid - administration & dosage</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Histones</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Maternal & child health</subject><subject>Metabolism</subject><subject>Methylation</subject><subject>Physiological aspects</subject><subject>Placenta</subject><subject>Placenta - drug effects</subject><subject>Placentation - drug effects</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Variables</subject><subject>Variance analysis</subject><subject>Vitamin B</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkl1rHSEQhqW0NCHNTX9AEXpTApvquqvrVTkkTVsI9NDmXjw6nnpw9VR3A_n3dZM0H6V64TDzzCvvMAi9peSUMUk-xplySqlo5Qt02BLRNpx37OWT-AAdl7IjyxFEcPYaHbBhkC3n9BDt1kEbiJNufkDQE1i81lmPMEEuWE_4HIK_hnyDfcS3hE8RTwlfpOANXhlv8c95vw8wLiK31Uqee-cg1wxeZ9hGHY2H8ga9cjoUOL5_j9DVxeers6_N5fcv385Wl41hnE2NoJZtgA6D663R3LZ9R4AR2cHA3QCDtL2mHKyzG2k73UnS9q0WktkaGMeO0Kc72f28GcEu5rIOap_9qPONStqr55Xof6ltulbLFDvZs6rw4V4hp98zlEmNvhgIQUdIc1GsznEgtBML-v4fdJfmHKu9SnHRV6qnj9RWB1A-ulQ_NouoWgkpJOk7KSt1-h-qXgujNymC8zX_rOHkrsHkVEoG92CSErUsh3pcjgq_ezqWB_TvKrA_9zaz_g</recordid><startdate>20240531</startdate><enddate>20240531</enddate><creator>Ren, Yating</creator><creator>Yang, Maoyuan</creator><creator>Ren, Siyi</creator><creator>Ge, Zhihao</creator><creator>Cao, Yu</creator><creator>Qin, Xinsheng</creator><creator>Sheng, Jie</creator><creator>Wang, Sufang</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0008-6794-2947</orcidid></search><sort><creationdate>20240531</creationdate><title>Placenta-Related Parameters at Delivery in Relation to Folic Acid Supplementation in Different Pregnancies</title><author>Ren, Yating ; 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Currently, most studies have focused on the effects of periconceptional folic acid (FA) supplementation on fetal development, and there is still a lack of population-based research exploring the association between FA use during pregnancy and placental development. This study aimed to investigate the impacts of FA supplementation in different pregnancies on placenta-related parameters at delivery. The study included 2708 pregnant women recruited from Ma'anshan City, Anhui Province, China, between May 2013 and September 2014. Information on FA use from one month before conception to delivery was collected. Placental length, width, and thickness were measured. Multivariable logistic regression analysis was used to assess the effects of FA supplementation in different pregnancies on placenta-related parameters. Based on multiple regression analysis, propensity score weighting was adopted to enhance comparability between different FA supplementation groups. Compared with FA non-users, FA supplementation before conception was associated with increased placental width (0.241 cm, 95%CI: 0.052-0.429,
= 0.013) and increased placental surface area (6.398 cm
, 95%CI: 1.407-11.389,
= 0.012), and FA use in early/middle pregnancy was, respectively, related with increased placental thickness (0.061 cm, 95%CI: 0.004-0.117,
= 0.036; 0.066 cm, 95%CI: 0.004-0.129,
= 0.038). FA use before conception could increase placental width and area, and FA use in early/middle pregnancy could increase placental thickness. To confirm the findings, further investigations are needed.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38892661</pmid><doi>10.3390/nu16111729</doi><orcidid>https://orcid.org/0009-0008-6794-2947</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Birth weight Blood pressure Blood vessels Body mass index Carbon Cell division China Delivery, Obstetric - methods Diabetes Dietary Supplements DNA binding proteins DNA methylation Female Fetuses Folic acid Folic Acid - administration & dosage Gene expression Genes Histones Homocysteine Humans Maternal & child health Metabolism Methylation Physiological aspects Placenta Placenta - drug effects Placentation - drug effects Pregnancy Pregnant women Questionnaires Regression analysis Variables Variance analysis Vitamin B Womens health Young Adult |
| title | Placenta-Related Parameters at Delivery in Relation to Folic Acid Supplementation in Different Pregnancies |
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