Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review
Our objective was to conduct a systematic review of the effects of hydrolyzed collagen supplementation on the proliferation and activation of fibroblasts. The search was conducted for journals that published articles in the English language, peer-reviewed, meeting the following criteria: (a) randomi...
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| Veröffentlicht in: | Nutrients 2024-05, Vol.16 (11), p.1543 |
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| creator | Inacio, Pedro Augusto Querido Chaluppe, Felipe Augusto Aguiar, Gerson Ferreira Coelho, Carly de Faria Vieira, Rodolfo P |
| description | Our objective was to conduct a systematic review of the effects of hydrolyzed collagen supplementation on the proliferation and activation of fibroblasts.
The search was conducted for journals that published articles in the English language, peer-reviewed, meeting the following criteria: (a) randomized clinical trials, (b) randomized studies in animals or humans, (c) in vitro studies, (d) studies using hydrolyzed collagens or collagen peptides, and (e) studies assessing alterations on fibroblasts as the primary or secondary outcome. We utilized the main journal databases PubMed/Web of Science and ongoing reviews by PROSPERO. For bias risk and methodological quality, we used an adaptation of the Downs and Black checklist. Our review followed the PRISMA checklist, conducted from February 2024 to the first week of March 2024, by two independent researchers (P.A.Q.I. and R.P.V.).
Eleven studies were included in this review, where our findings reinforce the notion that hydrolyzed collagens or collagen peptides at concentrations of 50-500 μg/mL are sufficient to stimulate fibroblasts in human and animal tissues without inducing toxicity. Different enzymatic processes may confer distinct biological properties to collagens, allowing for scenarios favoring fibroblast promotion or antioxidant effects. Lastly, collagens with lower molecular weights exhibit greater bioavailability to adjacent tissues.
Hydrolyzed collagens or collagen peptides with molecular sizes ranging from |
| doi_str_mv | 10.3390/nu16111543 |
| format | Article |
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The search was conducted for journals that published articles in the English language, peer-reviewed, meeting the following criteria: (a) randomized clinical trials, (b) randomized studies in animals or humans, (c) in vitro studies, (d) studies using hydrolyzed collagens or collagen peptides, and (e) studies assessing alterations on fibroblasts as the primary or secondary outcome. We utilized the main journal databases PubMed/Web of Science and ongoing reviews by PROSPERO. For bias risk and methodological quality, we used an adaptation of the Downs and Black checklist. Our review followed the PRISMA checklist, conducted from February 2024 to the first week of March 2024, by two independent researchers (P.A.Q.I. and R.P.V.).
Eleven studies were included in this review, where our findings reinforce the notion that hydrolyzed collagens or collagen peptides at concentrations of 50-500 μg/mL are sufficient to stimulate fibroblasts in human and animal tissues without inducing toxicity. Different enzymatic processes may confer distinct biological properties to collagens, allowing for scenarios favoring fibroblast promotion or antioxidant effects. Lastly, collagens with lower molecular weights exhibit greater bioavailability to adjacent tissues.
Hydrolyzed collagens or collagen peptides with molecular sizes ranging from <3 to 3000 KDa promote the stimulation of fibroblasts in human tissues.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16111543</identifier><identifier>PMID: 38892477</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Animals ; Bones ; Cell Proliferation - drug effects ; Collagen ; Collagen - pharmacology ; Connective tissue ; Dietary Supplements ; Enzymes ; Extracellular matrix ; Fibroblasts ; Fibroblasts - drug effects ; Humans ; Hydrolysis ; Industrial production ; Medical research ; Medicine, Experimental ; Molecular weight ; Peptides ; Proteins ; Quality control ; Skin ; Systematic Review ; Wound healing</subject><ispartof>Nutrients, 2024-05, Vol.16 (11), p.1543</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c433t-6403dcfc5754bc4d5d09d777a38898f1ad3766ac0fde0e22ca7bc83a97284c1d3</cites><orcidid>0009-0004-8651-6514 ; 0000-0001-9354-1460 ; 0000-0002-9298-4056 ; 0000-0001-6379-1143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11173906/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11173906/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38892477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inacio, Pedro Augusto Querido</creatorcontrib><creatorcontrib>Chaluppe, Felipe Augusto</creatorcontrib><creatorcontrib>Aguiar, Gerson Ferreira</creatorcontrib><creatorcontrib>Coelho, Carly de Faria</creatorcontrib><creatorcontrib>Vieira, Rodolfo P</creatorcontrib><title>Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Our objective was to conduct a systematic review of the effects of hydrolyzed collagen supplementation on the proliferation and activation of fibroblasts.
The search was conducted for journals that published articles in the English language, peer-reviewed, meeting the following criteria: (a) randomized clinical trials, (b) randomized studies in animals or humans, (c) in vitro studies, (d) studies using hydrolyzed collagens or collagen peptides, and (e) studies assessing alterations on fibroblasts as the primary or secondary outcome. We utilized the main journal databases PubMed/Web of Science and ongoing reviews by PROSPERO. For bias risk and methodological quality, we used an adaptation of the Downs and Black checklist. Our review followed the PRISMA checklist, conducted from February 2024 to the first week of March 2024, by two independent researchers (P.A.Q.I. and R.P.V.).
Eleven studies were included in this review, where our findings reinforce the notion that hydrolyzed collagens or collagen peptides at concentrations of 50-500 μg/mL are sufficient to stimulate fibroblasts in human and animal tissues without inducing toxicity. Different enzymatic processes may confer distinct biological properties to collagens, allowing for scenarios favoring fibroblast promotion or antioxidant effects. Lastly, collagens with lower molecular weights exhibit greater bioavailability to adjacent tissues.
Hydrolyzed collagens or collagen peptides with molecular sizes ranging from <3 to 3000 KDa promote the stimulation of fibroblasts in human tissues.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Bones</subject><subject>Cell Proliferation - drug effects</subject><subject>Collagen</subject><subject>Collagen - pharmacology</subject><subject>Connective tissue</subject><subject>Dietary Supplements</subject><subject>Enzymes</subject><subject>Extracellular matrix</subject><subject>Fibroblasts</subject><subject>Fibroblasts - drug effects</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Industrial production</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Molecular weight</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Quality control</subject><subject>Skin</subject><subject>Systematic Review</subject><subject>Wound healing</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkl1rFDEUhoNYbGl74w-QgDdS2JpMMpMZb2RZWysUBKvXIZOcrCkzyZpkVtZfb4bWui1NLvL1nDfnvByEXlNyzlhH3vuJNpTSmrMX6Kgiolo0DWcv9_aH6DSlWzIPQUTDXqFD1rZdxYU4QubCWtA54WDx1c7EMOz-gMGrMAxqDR6rhBX-5CCruMM302YzwAg-4-Dxpetj6AeVMl7q7LYqu-A_4CW-2aUMYzlq_A22Dn6foAOrhgSn9-sx-nF58X11tbj--vnLanm90JyxvGg4YUZbXYua95qb2pDOCCHUnG5rqTJMNI3SxBogUFVaiV63THWiarmmhh2jj3e6m6kfweiSaFSD3EQ3lvRlUE4-fvHup1yHrSwGimJmUxTe3SvE8GuClOXokoZihocwJcmKhS0hrO0K-vYJehum6Et9hWpETSgne9RaDSCdt6F8rGdRuRSd6EhNu5k6f4Yq08DodPBgXbl_FHB2F6BjSCmCfSiSEjn3hfzfFwV-s2_LA_qvC9hfZ5Ox2g</recordid><startdate>20240521</startdate><enddate>20240521</enddate><creator>Inacio, Pedro Augusto Querido</creator><creator>Chaluppe, Felipe Augusto</creator><creator>Aguiar, Gerson Ferreira</creator><creator>Coelho, Carly de Faria</creator><creator>Vieira, Rodolfo P</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0004-8651-6514</orcidid><orcidid>https://orcid.org/0000-0001-9354-1460</orcidid><orcidid>https://orcid.org/0000-0002-9298-4056</orcidid><orcidid>https://orcid.org/0000-0001-6379-1143</orcidid></search><sort><creationdate>20240521</creationdate><title>Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review</title><author>Inacio, Pedro Augusto Querido ; 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The search was conducted for journals that published articles in the English language, peer-reviewed, meeting the following criteria: (a) randomized clinical trials, (b) randomized studies in animals or humans, (c) in vitro studies, (d) studies using hydrolyzed collagens or collagen peptides, and (e) studies assessing alterations on fibroblasts as the primary or secondary outcome. We utilized the main journal databases PubMed/Web of Science and ongoing reviews by PROSPERO. For bias risk and methodological quality, we used an adaptation of the Downs and Black checklist. Our review followed the PRISMA checklist, conducted from February 2024 to the first week of March 2024, by two independent researchers (P.A.Q.I. and R.P.V.).
Eleven studies were included in this review, where our findings reinforce the notion that hydrolyzed collagens or collagen peptides at concentrations of 50-500 μg/mL are sufficient to stimulate fibroblasts in human and animal tissues without inducing toxicity. Different enzymatic processes may confer distinct biological properties to collagens, allowing for scenarios favoring fibroblast promotion or antioxidant effects. Lastly, collagens with lower molecular weights exhibit greater bioavailability to adjacent tissues.
Hydrolyzed collagens or collagen peptides with molecular sizes ranging from <3 to 3000 KDa promote the stimulation of fibroblasts in human tissues.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38892477</pmid><doi>10.3390/nu16111543</doi><orcidid>https://orcid.org/0009-0004-8651-6514</orcidid><orcidid>https://orcid.org/0000-0001-9354-1460</orcidid><orcidid>https://orcid.org/0000-0002-9298-4056</orcidid><orcidid>https://orcid.org/0000-0001-6379-1143</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Amino acids Animals Bones Cell Proliferation - drug effects Collagen Collagen - pharmacology Connective tissue Dietary Supplements Enzymes Extracellular matrix Fibroblasts Fibroblasts - drug effects Humans Hydrolysis Industrial production Medical research Medicine, Experimental Molecular weight Peptides Proteins Quality control Skin Systematic Review Wound healing |
| title | Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review |
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