hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis -Induced Periodontal Disease and Systemic Disorders in ApoE -Deficient Mice
GV1001, an anticancer vaccine, exhibits other biological functions, including anti-inflammatory and antioxidant activity. It also suppresses the development of ligature-induced periodontitis in mice. ( ), a major human oral bacterium implicated in the development of periodontitis, is associated with...
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| Veröffentlicht in: | International journal of molecular sciences 2024-06, Vol.25 (11), p.6126 |
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| creator | Chen, Wei Kim, Sharon Y Lee, Alicia Kim, Yun-Jeong Chang, Chungyu Ton-That, Hung Kim, Reuben Kim, Sangjae Park, No-Hee |
| description | GV1001, an anticancer vaccine, exhibits other biological functions, including anti-inflammatory and antioxidant activity. It also suppresses the development of ligature-induced periodontitis in mice.
(
), a major human oral bacterium implicated in the development of periodontitis, is associated with various systemic disorders, such as atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the protective effects of GV1001 against
-induced periodontal disease, atherosclerosis, and AD-like conditions in
(
)-deficient mice. GV1001 effectively mitigated the development of
-induced periodontal disease, atherosclerosis, and AD-like conditions by counteracting
-induced local and systemic inflammation, partly by inhibiting the accumulation of
DNA aggregates,
lipopolysaccharides (LPS), and gingipains in the gingival tissue, arterial wall, and brain. GV1001 attenuated the development of atherosclerosis by inhibiting vascular inflammation, lipid deposition in the arterial wall, endothelial to mesenchymal cell transition (EndMT), the expression of Cluster of Differentiation 47 (CD47) from arterial smooth muscle cells, and the formation of foam cells in mice with
-induced periodontal disease. GV1001 also suppressed the accumulation of AD biomarkers in the brains of mice with periodontal disease. Overall, these findings suggest that GV1001 holds promise as a preventive agent in the development of atherosclerosis and AD-like conditions associated with periodontal disease. |
| doi_str_mv | 10.3390/ijms25116126 |
| format | Article |
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(
), a major human oral bacterium implicated in the development of periodontitis, is associated with various systemic disorders, such as atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the protective effects of GV1001 against
-induced periodontal disease, atherosclerosis, and AD-like conditions in
(
)-deficient mice. GV1001 effectively mitigated the development of
-induced periodontal disease, atherosclerosis, and AD-like conditions by counteracting
-induced local and systemic inflammation, partly by inhibiting the accumulation of
DNA aggregates,
lipopolysaccharides (LPS), and gingipains in the gingival tissue, arterial wall, and brain. GV1001 attenuated the development of atherosclerosis by inhibiting vascular inflammation, lipid deposition in the arterial wall, endothelial to mesenchymal cell transition (EndMT), the expression of Cluster of Differentiation 47 (CD47) from arterial smooth muscle cells, and the formation of foam cells in mice with
-induced periodontal disease. GV1001 also suppressed the accumulation of AD biomarkers in the brains of mice with periodontal disease. Overall, these findings suggest that GV1001 holds promise as a preventive agent in the development of atherosclerosis and AD-like conditions associated with periodontal disease.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25116126</identifier><identifier>PMID: 38892314</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer Disease - metabolism ; Alzheimer Disease - microbiology ; Alzheimer Disease - prevention & control ; Animals ; Apolipoproteins ; Apolipoproteins E - deficiency ; Atherosclerosis ; Atherosclerosis - metabolism ; Atherosclerosis - microbiology ; Atherosclerosis - prevention & control ; Bacteroidaceae Infections - complications ; Bacteroidaceae Infections - microbiology ; Bacteroidaceae Infections - prevention & control ; Brain ; California ; Cancer vaccines ; Clinical trials ; Cytokines ; Disease Models, Animal ; Diseases ; Germany ; Gum disease ; Humans ; Hypotheses ; Inflammation ; Male ; Massachusetts ; Medical research ; Medicine, Experimental ; Mice ; Mice, Inbred C57BL ; Peptide Fragments - pharmacology ; Peptides ; Periodontal Diseases - microbiology ; Periodontal Diseases - prevention & control ; Periodontitis - microbiology ; Periodontitis - prevention & control ; Periodontium ; Porphyromonas gingivalis ; Scientific equipment and supplies industry ; Telomerase - metabolism ; United States</subject><ispartof>International journal of molecular sciences, 2024-06, Vol.25 (11), p.6126</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-85c409db4996a21b15cb3d401b8cf5c63d69458162ecfe60369c365e86f99e6b3</cites><orcidid>0000-0001-7886-1773 ; 0000-0003-4481-3137 ; 0009-0003-8877-1060 ; 0000-0001-6127-3086 ; 0000-0001-7467-4954 ; 0000-0003-1611-0469</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172542/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172542/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38892314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Kim, Sharon Y</creatorcontrib><creatorcontrib>Lee, Alicia</creatorcontrib><creatorcontrib>Kim, Yun-Jeong</creatorcontrib><creatorcontrib>Chang, Chungyu</creatorcontrib><creatorcontrib>Ton-That, Hung</creatorcontrib><creatorcontrib>Kim, Reuben</creatorcontrib><creatorcontrib>Kim, Sangjae</creatorcontrib><creatorcontrib>Park, No-Hee</creatorcontrib><title>hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis -Induced Periodontal Disease and Systemic Disorders in ApoE -Deficient Mice</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>GV1001, an anticancer vaccine, exhibits other biological functions, including anti-inflammatory and antioxidant activity. It also suppresses the development of ligature-induced periodontitis in mice.
(
), a major human oral bacterium implicated in the development of periodontitis, is associated with various systemic disorders, such as atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the protective effects of GV1001 against
-induced periodontal disease, atherosclerosis, and AD-like conditions in
(
)-deficient mice. GV1001 effectively mitigated the development of
-induced periodontal disease, atherosclerosis, and AD-like conditions by counteracting
-induced local and systemic inflammation, partly by inhibiting the accumulation of
DNA aggregates,
lipopolysaccharides (LPS), and gingipains in the gingival tissue, arterial wall, and brain. GV1001 attenuated the development of atherosclerosis by inhibiting vascular inflammation, lipid deposition in the arterial wall, endothelial to mesenchymal cell transition (EndMT), the expression of Cluster of Differentiation 47 (CD47) from arterial smooth muscle cells, and the formation of foam cells in mice with
-induced periodontal disease. GV1001 also suppressed the accumulation of AD biomarkers in the brains of mice with periodontal disease. Overall, these findings suggest that GV1001 holds promise as a preventive agent in the development of atherosclerosis and AD-like conditions associated with periodontal disease.</description><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - microbiology</subject><subject>Alzheimer Disease - prevention & control</subject><subject>Animals</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins E - deficiency</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - microbiology</subject><subject>Atherosclerosis - prevention & control</subject><subject>Bacteroidaceae Infections - complications</subject><subject>Bacteroidaceae Infections - microbiology</subject><subject>Bacteroidaceae Infections - prevention & control</subject><subject>Brain</subject><subject>California</subject><subject>Cancer vaccines</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Disease Models, Animal</subject><subject>Diseases</subject><subject>Germany</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Inflammation</subject><subject>Male</subject><subject>Massachusetts</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptides</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontal Diseases - prevention & control</subject><subject>Periodontitis - microbiology</subject><subject>Periodontitis - prevention & control</subject><subject>Periodontium</subject><subject>Porphyromonas gingivalis</subject><subject>Scientific equipment and supplies industry</subject><subject>Telomerase - metabolism</subject><subject>United States</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v1DAQhiMEoqVw44wsceFAir_ixCe06m5LpSJWsHC1HGey61ViBzu70v4ZfitOW8oWIR88nnnmHc14suw1weeMSfzBbvtIC0IEoeJJdko4pTnGonx6ZJ9kL2LcYkwZLeTz7IRVlaSM8NPs12a1-LpCSxhG2wC6DHrdgxvR1Q-CMUHLAPv0jGjcAJonu_PDbdy3aOnDsDkE33unI1pbt7Z73dmI8mvX7Aw0STVY33g36g7NbQQdAWnXoG-HOEJvzeT0oYEQkXVoNvgFyufQWmOnEp-tgZfZs1Z3EV7d32fZ98vF6uJTfvPl6vpidpMbzsoxrwrDsWxqLqXQlNSkMDVrOCZ1ZdrCCNYIyYuKCAqmBYGZkIaJAirRSgmiZmfZxzvdYVf30JhUP-hODcH2OhyU11Y9jji7UWu_V4SQkhacJoV39wrB_9xBHFVvo4Gu0w78LiqGS1ylH7hF3_6Dbv0uuNRfokTJBWe0-kutdQfKutanwmYSVbNSlhKXgvBEnf-HSqeZBuxdmmbyP0p4f5dggo8xQPvQJMFqWih1vFAJf3M8mAf4zwax39Daxk4</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Chen, Wei</creator><creator>Kim, Sharon Y</creator><creator>Lee, Alicia</creator><creator>Kim, Yun-Jeong</creator><creator>Chang, Chungyu</creator><creator>Ton-That, Hung</creator><creator>Kim, Reuben</creator><creator>Kim, Sangjae</creator><creator>Park, No-Hee</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7886-1773</orcidid><orcidid>https://orcid.org/0000-0003-4481-3137</orcidid><orcidid>https://orcid.org/0009-0003-8877-1060</orcidid><orcidid>https://orcid.org/0000-0001-6127-3086</orcidid><orcidid>https://orcid.org/0000-0001-7467-4954</orcidid><orcidid>https://orcid.org/0000-0003-1611-0469</orcidid></search><sort><creationdate>20240601</creationdate><title>hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis -Induced Periodontal Disease and Systemic Disorders in ApoE -Deficient Mice</title><author>Chen, Wei ; Kim, Sharon Y ; Lee, Alicia ; Kim, Yun-Jeong ; Chang, Chungyu ; Ton-That, Hung ; Kim, Reuben ; Kim, Sangjae ; Park, No-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-85c409db4996a21b15cb3d401b8cf5c63d69458162ecfe60369c365e86f99e6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - microbiology</topic><topic>Alzheimer Disease - prevention & control</topic><topic>Animals</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins E - deficiency</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - metabolism</topic><topic>Atherosclerosis - microbiology</topic><topic>Atherosclerosis - prevention & control</topic><topic>Bacteroidaceae Infections - complications</topic><topic>Bacteroidaceae Infections - microbiology</topic><topic>Bacteroidaceae Infections - prevention & control</topic><topic>Brain</topic><topic>California</topic><topic>Cancer vaccines</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Disease Models, Animal</topic><topic>Diseases</topic><topic>Germany</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Inflammation</topic><topic>Male</topic><topic>Massachusetts</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptides</topic><topic>Periodontal Diseases - microbiology</topic><topic>Periodontal Diseases - prevention & control</topic><topic>Periodontitis - microbiology</topic><topic>Periodontitis - prevention & control</topic><topic>Periodontium</topic><topic>Porphyromonas gingivalis</topic><topic>Scientific equipment and supplies industry</topic><topic>Telomerase - metabolism</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Kim, Sharon Y</creatorcontrib><creatorcontrib>Lee, Alicia</creatorcontrib><creatorcontrib>Kim, Yun-Jeong</creatorcontrib><creatorcontrib>Chang, Chungyu</creatorcontrib><creatorcontrib>Ton-That, Hung</creatorcontrib><creatorcontrib>Kim, Reuben</creatorcontrib><creatorcontrib>Kim, Sangjae</creatorcontrib><creatorcontrib>Park, No-Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wei</au><au>Kim, Sharon Y</au><au>Lee, Alicia</au><au>Kim, Yun-Jeong</au><au>Chang, Chungyu</au><au>Ton-That, Hung</au><au>Kim, Reuben</au><au>Kim, Sangjae</au><au>Park, No-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis -Induced Periodontal Disease and Systemic Disorders in ApoE -Deficient Mice</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>25</volume><issue>11</issue><spage>6126</spage><pages>6126-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>GV1001, an anticancer vaccine, exhibits other biological functions, including anti-inflammatory and antioxidant activity. It also suppresses the development of ligature-induced periodontitis in mice.
(
), a major human oral bacterium implicated in the development of periodontitis, is associated with various systemic disorders, such as atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the protective effects of GV1001 against
-induced periodontal disease, atherosclerosis, and AD-like conditions in
(
)-deficient mice. GV1001 effectively mitigated the development of
-induced periodontal disease, atherosclerosis, and AD-like conditions by counteracting
-induced local and systemic inflammation, partly by inhibiting the accumulation of
DNA aggregates,
lipopolysaccharides (LPS), and gingipains in the gingival tissue, arterial wall, and brain. GV1001 attenuated the development of atherosclerosis by inhibiting vascular inflammation, lipid deposition in the arterial wall, endothelial to mesenchymal cell transition (EndMT), the expression of Cluster of Differentiation 47 (CD47) from arterial smooth muscle cells, and the formation of foam cells in mice with
-induced periodontal disease. GV1001 also suppressed the accumulation of AD biomarkers in the brains of mice with periodontal disease. Overall, these findings suggest that GV1001 holds promise as a preventive agent in the development of atherosclerosis and AD-like conditions associated with periodontal disease.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38892314</pmid><doi>10.3390/ijms25116126</doi><orcidid>https://orcid.org/0000-0001-7886-1773</orcidid><orcidid>https://orcid.org/0000-0003-4481-3137</orcidid><orcidid>https://orcid.org/0009-0003-8877-1060</orcidid><orcidid>https://orcid.org/0000-0001-6127-3086</orcidid><orcidid>https://orcid.org/0000-0001-7467-4954</orcidid><orcidid>https://orcid.org/0000-0003-1611-0469</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Alzheimer Disease - metabolism Alzheimer Disease - microbiology Alzheimer Disease - prevention & control Animals Apolipoproteins Apolipoproteins E - deficiency Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - microbiology Atherosclerosis - prevention & control Bacteroidaceae Infections - complications Bacteroidaceae Infections - microbiology Bacteroidaceae Infections - prevention & control Brain California Cancer vaccines Clinical trials Cytokines Disease Models, Animal Diseases Germany Gum disease Humans Hypotheses Inflammation Male Massachusetts Medical research Medicine, Experimental Mice Mice, Inbred C57BL Peptide Fragments - pharmacology Peptides Periodontal Diseases - microbiology Periodontal Diseases - prevention & control Periodontitis - microbiology Periodontitis - prevention & control Periodontium Porphyromonas gingivalis Scientific equipment and supplies industry Telomerase - metabolism United States |
| title | hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis -Induced Periodontal Disease and Systemic Disorders in ApoE -Deficient Mice |
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