Harnessing Metformin's Immunomodulatory Effects on Immune Cells to Combat Breast Cancer

Metformin, a medication known for its anti-glycemic properties, also demonstrates potent immune system activation. In our study, using a 4T1 breast cancer model in BALB/C WT mice, we examined metformin's impact on the functional phenotype of multiple immune cells, with a specific emphasis on na...

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Veröffentlicht in:	International journal of molecular sciences 2024-06, Vol.25 (11), p.5869
Hauptverfasser:	Petrovic, Andjela, Jovanovic, Ivan, Stojanovic, Bojan, Dimitrijevic Stojanovic, Milica, Stojanovic, Bojana S, Jurisevic, Milena, Simovic Markovic, Bojana, Jovanovic, Marina, Jovanovic, Milan, Jovanovic, Mihailo, Gajovic, Nevena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies Care and treatment Cell Line, Tumor Cytokines Cytotoxicity Dendritic cells Development and progression Diabetes Diagnosis Female Genotype & phenotype Immune system Immunomodulating Agents - pharmacology Immunomodulators Immunotherapy Investigations Lymphocytes Metformin Metformin - pharmacology Metformin - therapeutic use Mice Mice, Inbred BALB C Myeloid-Derived Suppressor Cells - drug effects Myeloid-Derived Suppressor Cells - immunology Myeloid-Derived Suppressor Cells - metabolism Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism T cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tumors
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