From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases
Inflammatory bowel diseases (IBDs) are characterized by chronic gastrointestinal inflammation due to abnormal immune responses to gut microflora. The gut-brain axis is disrupted in IBDs, leading to neurobiological imbalances and affective symptoms. Systemic inflammation in IBDs affects the brain...
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| Veröffentlicht in: | International journal of molecular sciences 2024-06, Vol.25 (11), p.5676 |
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| creator | Sarb, Oliviu-Florentiu Sarb, Adriana-Daniela Iacobescu, Maria Vlad, Irina-Maria Milaciu, Mircea-Vasile Ciurmarnean, Lorena Vacaras, Vitalie Tantau, Alina-Ioana |
| description | Inflammatory bowel diseases (IBDs) are characterized by chronic gastrointestinal inflammation due to abnormal immune responses to gut microflora. The gut-brain axis is disrupted in IBDs, leading to neurobiological imbalances and affective symptoms. Systemic inflammation in IBDs affects the brain's inflammatory response system, hormonal axis, and blood-brain barrier integrity, influencing the gut microbiota. This review aims to explore the association between dysregulations in the gut-brain axis, serum biomarkers, and the development of cognitive disorders. Studies suggest a potential association between IBDs and the development of neurodegeneration. The mechanisms include systemic inflammation, nutritional deficiency, GBA dysfunction, and the effect of genetics and comorbidities. The objective is to identify potential correlations and propose future research directions to understand the impact of altered microbiomes and intestinal barrier functions on neurodegeneration. Serum levels of vitamins, inflammatory and neuronal damage biomarkers, and neuronal growth factors have been investigated for their potential to predict the development of neurodegenerative diseases, but current results are inconclusive and require more studies. |
| doi_str_mv | 10.3390/ijms25115676 |
| format | Article |
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The gut-brain axis is disrupted in IBDs, leading to neurobiological imbalances and affective symptoms. Systemic inflammation in IBDs affects the brain's inflammatory response system, hormonal axis, and blood-brain barrier integrity, influencing the gut microbiota. This review aims to explore the association between dysregulations in the gut-brain axis, serum biomarkers, and the development of cognitive disorders. Studies suggest a potential association between IBDs and the development of neurodegeneration. The mechanisms include systemic inflammation, nutritional deficiency, GBA dysfunction, and the effect of genetics and comorbidities. The objective is to identify potential correlations and propose future research directions to understand the impact of altered microbiomes and intestinal barrier functions on neurodegeneration. Serum levels of vitamins, inflammatory and neuronal damage biomarkers, and neuronal growth factors have been investigated for their potential to predict the development of neurodegenerative diseases, but current results are inconclusive and require more studies.</description><subject>Animals</subject><subject>B cells</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bowel disease</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain research</subject><subject>Brain-Gut Axis</subject><subject>Chronic illnesses</subject><subject>Cognition & reasoning</subject><subject>Cognition disorders</subject><subject>Cognitive ability</subject><subject>Degeneration</subject><subject>Dementia</subject><subject>Development and progression</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - 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The gut-brain axis is disrupted in IBDs, leading to neurobiological imbalances and affective symptoms. Systemic inflammation in IBDs affects the brain's inflammatory response system, hormonal axis, and blood-brain barrier integrity, influencing the gut microbiota. This review aims to explore the association between dysregulations in the gut-brain axis, serum biomarkers, and the development of cognitive disorders. Studies suggest a potential association between IBDs and the development of neurodegeneration. The mechanisms include systemic inflammation, nutritional deficiency, GBA dysfunction, and the effect of genetics and comorbidities. The objective is to identify potential correlations and propose future research directions to understand the impact of altered microbiomes and intestinal barrier functions on neurodegeneration. 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| subjects | Animals B cells Biological markers Biomarkers Biomarkers - blood Bowel disease Brain - metabolism Brain - pathology Brain research Brain-Gut Axis Chronic illnesses Cognition & reasoning Cognition disorders Cognitive ability Degeneration Dementia Development and progression Gastrointestinal Microbiome Humans Immune response Immune system Inflammation Inflammatory bowel diseases Inflammatory Bowel Diseases - blood Medical research Medicine, Experimental Metabolites Microbiota Microbiota (Symbiotic organisms) Nervous system Neurodegeneration Neurodegenerative Diseases - blood Neurons Neurophysiology Review Risk factors |
| title | From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases |
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