MicroRNA‐7 deficiency ameliorates d‐galactose‐induced aging in mice by regulating senescence of Kupffer cells

Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA‐7 (miR‐7) as a novel regulator of immune cell function and related diseases. However, the potential role of miR‐7 in aging remains unexplored. Here, we investigated the contr...

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Veröffentlicht in:	Aging cell 2024-06, Vol.23 (6), p.e14145-n/a
Hauptverfasser:	Wang, Ya, Qiu, Hui, Chen, Shipeng, Li, Dongmei, Zhao, Xu, Guo, Mengmeng, Li, Nana, Chen, Chao, Qin, Ming, Zhou, Ya, Xiao, Daimin, Zhao, Juanjuan, Xu, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Age Aging Animals Antibodies CD4 antigen Cell activation Cellular Senescence - genetics D-Galactose Experiments Flow cytometry Galactose Galactose - metabolism Genotype & phenotype Hepatocytes Hybridization IL-1β Immune system Inflammatory diseases Interleukin-1beta - metabolism Kinases KLF4 KLF4 protein Kruppel-Like Factor 4 - metabolism Kupffer cells Kupffer Cells - metabolism Laboratory animals Liver Lymphocytes T Main Issue Male Mice Mice, Inbred C57BL MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism microRNA‐7 miRNA NF-κB protein Phenotypes Proteins Reagents Senescence senescent Kupffer cells
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