Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA
INTRODUCTION Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations. METHODS In the Multi‐Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility‐weighted imaging sequences using deep learnin...
Gespeichert in:
| Veröffentlicht in: | Alzheimer's & dementia 2023-09, Vol.19 (9), p.4139-4149 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4149 |
|---|---|
| container_issue | 9 |
| container_start_page | 4139 |
| container_title | Alzheimer's & dementia |
| container_volume | 19 |
| creator | Jensen, Paul N. Rashid, Tanweer Ware, Jeffrey B. Cui, Yuhan Sitlani, Colleen M. Austin, Thomas R. Longstreth, W. T. Bertoni, Alain G. Mamourian, Elizabeth Bryan, R. Nick Nasrallah, Ilya M. Habes, Mohamad Heckbert, Susan R. |
| description | INTRODUCTION
Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations.
METHODS
In the Multi‐Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility‐weighted imaging sequences using deep learning models followed by radiologist review.
RESULTS
Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy.
DISCUSSION
Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology. |
| doi_str_mv | 10.1002/alz.13346 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11163989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2824687040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3816-53e2ae37a37e5bae0321dd4c9ec1ce20e2d809ebe013cec1ccd57075558c8e183</originalsourceid><addsrcrecordid>eNp1kUtLAzEUhYMoWqsL_4BkqdBp82hmMisp4gsqgq-Fm5DJ3Gp0OqnJ1FJ_vamtRReubrj57rmXcxA6oKRLCWE9XX12Kef9dAO1qBAsESzLN9fvlOyg3RBeCekTScU22uEZk3meyRZ6HITgjNWNdTV2I1x4bWs8tsa7ogIoA57Z5gV7G97wSJvG-dDBxj3XdjHRwbou8fXtFR5r_wY-4Dh8fXY32ENbI10F2F_VNno4P7s_vUyGNxdXp4NhYrikaSI4MA080zwDUWggnNGy7JscDDXACLBSkhwKIJSbRc-UIiOZEEIaCVTyNjpZ6k6mxRhKA3XjdaUm3saD5sppq_7-1PZFPbsPRSlNeS7zqHC0UvDufQqhUWMbDFSVrsFNg2KS9VOZResierxEozkheBit91CiFkGoGIT6DiKyh78PW5M_zkegtwRmtoL5_0pqMHxaSn4BajKTVg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2824687040</pqid></control><display><type>article</type><title>Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jensen, Paul N. ; Rashid, Tanweer ; Ware, Jeffrey B. ; Cui, Yuhan ; Sitlani, Colleen M. ; Austin, Thomas R. ; Longstreth, W. T. ; Bertoni, Alain G. ; Mamourian, Elizabeth ; Bryan, R. Nick ; Nasrallah, Ilya M. ; Habes, Mohamad ; Heckbert, Susan R.</creator><creatorcontrib>Jensen, Paul N. ; Rashid, Tanweer ; Ware, Jeffrey B. ; Cui, Yuhan ; Sitlani, Colleen M. ; Austin, Thomas R. ; Longstreth, W. T. ; Bertoni, Alain G. ; Mamourian, Elizabeth ; Bryan, R. Nick ; Nasrallah, Ilya M. ; Habes, Mohamad ; Heckbert, Susan R.</creatorcontrib><description>INTRODUCTION
Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations.
METHODS
In the Multi‐Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility‐weighted imaging sequences using deep learning models followed by radiologist review.
RESULTS
Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy.
DISCUSSION
Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.13346</identifier><identifier>PMID: 37289978</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Atrial Fibrillation ; Brain - diagnostic imaging ; Brain - pathology ; brain magnetic resonance imaging ; brain microbleeds ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - epidemiology ; Cognition ; deep learning ; Humans ; hypertension ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Multi‐Ethnic Study of Atherosclerosis ; race and ethnicity ; Risk Factors ; small vessel disease ; white matter fractional anisotropy ; white matter hyperintensity</subject><ispartof>Alzheimer's & dementia, 2023-09, Vol.19 (9), p.4139-4149</ispartof><rights>2023 the Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3816-53e2ae37a37e5bae0321dd4c9ec1ce20e2d809ebe013cec1ccd57075558c8e183</citedby><cites>FETCH-LOGICAL-c3816-53e2ae37a37e5bae0321dd4c9ec1ce20e2d809ebe013cec1ccd57075558c8e183</cites><orcidid>0000-0002-7100-512X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falz.13346$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falz.13346$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37289978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Paul N.</creatorcontrib><creatorcontrib>Rashid, Tanweer</creatorcontrib><creatorcontrib>Ware, Jeffrey B.</creatorcontrib><creatorcontrib>Cui, Yuhan</creatorcontrib><creatorcontrib>Sitlani, Colleen M.</creatorcontrib><creatorcontrib>Austin, Thomas R.</creatorcontrib><creatorcontrib>Longstreth, W. T.</creatorcontrib><creatorcontrib>Bertoni, Alain G.</creatorcontrib><creatorcontrib>Mamourian, Elizabeth</creatorcontrib><creatorcontrib>Bryan, R. Nick</creatorcontrib><creatorcontrib>Nasrallah, Ilya M.</creatorcontrib><creatorcontrib>Habes, Mohamad</creatorcontrib><creatorcontrib>Heckbert, Susan R.</creatorcontrib><title>Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>INTRODUCTION
Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations.
METHODS
In the Multi‐Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility‐weighted imaging sequences using deep learning models followed by radiologist review.
RESULTS
Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy.
DISCUSSION
Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.</description><subject>Aged</subject><subject>Atrial Fibrillation</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>brain magnetic resonance imaging</subject><subject>brain microbleeds</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>Cognition</subject><subject>deep learning</subject><subject>Humans</subject><subject>hypertension</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multi‐Ethnic Study of Atherosclerosis</subject><subject>race and ethnicity</subject><subject>Risk Factors</subject><subject>small vessel disease</subject><subject>white matter fractional anisotropy</subject><subject>white matter hyperintensity</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLAzEUhYMoWqsL_4BkqdBp82hmMisp4gsqgq-Fm5DJ3Gp0OqnJ1FJ_vamtRReubrj57rmXcxA6oKRLCWE9XX12Kef9dAO1qBAsESzLN9fvlOyg3RBeCekTScU22uEZk3meyRZ6HITgjNWNdTV2I1x4bWs8tsa7ogIoA57Z5gV7G97wSJvG-dDBxj3XdjHRwbou8fXtFR5r_wY-4Dh8fXY32ENbI10F2F_VNno4P7s_vUyGNxdXp4NhYrikaSI4MA080zwDUWggnNGy7JscDDXACLBSkhwKIJSbRc-UIiOZEEIaCVTyNjpZ6k6mxRhKA3XjdaUm3saD5sppq_7-1PZFPbsPRSlNeS7zqHC0UvDufQqhUWMbDFSVrsFNg2KS9VOZResierxEozkheBit91CiFkGoGIT6DiKyh78PW5M_zkegtwRmtoL5_0pqMHxaSn4BajKTVg</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Jensen, Paul N.</creator><creator>Rashid, Tanweer</creator><creator>Ware, Jeffrey B.</creator><creator>Cui, Yuhan</creator><creator>Sitlani, Colleen M.</creator><creator>Austin, Thomas R.</creator><creator>Longstreth, W. T.</creator><creator>Bertoni, Alain G.</creator><creator>Mamourian, Elizabeth</creator><creator>Bryan, R. Nick</creator><creator>Nasrallah, Ilya M.</creator><creator>Habes, Mohamad</creator><creator>Heckbert, Susan R.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7100-512X</orcidid></search><sort><creationdate>202309</creationdate><title>Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA</title><author>Jensen, Paul N. ; Rashid, Tanweer ; Ware, Jeffrey B. ; Cui, Yuhan ; Sitlani, Colleen M. ; Austin, Thomas R. ; Longstreth, W. T. ; Bertoni, Alain G. ; Mamourian, Elizabeth ; Bryan, R. Nick ; Nasrallah, Ilya M. ; Habes, Mohamad ; Heckbert, Susan R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3816-53e2ae37a37e5bae0321dd4c9ec1ce20e2d809ebe013cec1ccd57075558c8e183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Atrial Fibrillation</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>brain magnetic resonance imaging</topic><topic>brain microbleeds</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>Cerebral Hemorrhage - epidemiology</topic><topic>Cognition</topic><topic>deep learning</topic><topic>Humans</topic><topic>hypertension</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multi‐Ethnic Study of Atherosclerosis</topic><topic>race and ethnicity</topic><topic>Risk Factors</topic><topic>small vessel disease</topic><topic>white matter fractional anisotropy</topic><topic>white matter hyperintensity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Paul N.</creatorcontrib><creatorcontrib>Rashid, Tanweer</creatorcontrib><creatorcontrib>Ware, Jeffrey B.</creatorcontrib><creatorcontrib>Cui, Yuhan</creatorcontrib><creatorcontrib>Sitlani, Colleen M.</creatorcontrib><creatorcontrib>Austin, Thomas R.</creatorcontrib><creatorcontrib>Longstreth, W. T.</creatorcontrib><creatorcontrib>Bertoni, Alain G.</creatorcontrib><creatorcontrib>Mamourian, Elizabeth</creatorcontrib><creatorcontrib>Bryan, R. Nick</creatorcontrib><creatorcontrib>Nasrallah, Ilya M.</creatorcontrib><creatorcontrib>Habes, Mohamad</creatorcontrib><creatorcontrib>Heckbert, Susan R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Paul N.</au><au>Rashid, Tanweer</au><au>Ware, Jeffrey B.</au><au>Cui, Yuhan</au><au>Sitlani, Colleen M.</au><au>Austin, Thomas R.</au><au>Longstreth, W. T.</au><au>Bertoni, Alain G.</au><au>Mamourian, Elizabeth</au><au>Bryan, R. Nick</au><au>Nasrallah, Ilya M.</au><au>Habes, Mohamad</au><au>Heckbert, Susan R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2023-09</date><risdate>2023</risdate><volume>19</volume><issue>9</issue><spage>4139</spage><epage>4149</epage><pages>4139-4149</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>INTRODUCTION
Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations.
METHODS
In the Multi‐Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility‐weighted imaging sequences using deep learning models followed by radiologist review.
RESULTS
Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy.
DISCUSSION
Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.</abstract><cop>United States</cop><pmid>37289978</pmid><doi>10.1002/alz.13346</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7100-512X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-5260 |
| ispartof | Alzheimer's & dementia, 2023-09, Vol.19 (9), p.4139-4149 |
| issn | 1552-5260 1552-5279 1552-5279 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11163989 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Atrial Fibrillation Brain - diagnostic imaging Brain - pathology brain magnetic resonance imaging brain microbleeds Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - epidemiology Cognition deep learning Humans hypertension Magnetic Resonance Imaging - methods Male Middle Aged Multi‐Ethnic Study of Atherosclerosis race and ethnicity Risk Factors small vessel disease white matter fractional anisotropy white matter hyperintensity |
| title | Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T01%3A49%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20brain%20microbleeds%20with%20risk%20factors,%20cognition,%20and%20MRI%20markers%20in%20MESA&rft.jtitle=Alzheimer's%20&%20dementia&rft.au=Jensen,%20Paul%20N.&rft.date=2023-09&rft.volume=19&rft.issue=9&rft.spage=4139&rft.epage=4149&rft.pages=4139-4149&rft.issn=1552-5260&rft.eissn=1552-5279&rft_id=info:doi/10.1002/alz.13346&rft_dat=%3Cproquest_pubme%3E2824687040%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2824687040&rft_id=info:pmid/37289978&rfr_iscdi=true |