Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination

Male development in mammals depends on the activity of the two SOX gene: Sry and Sox9, in the embryonic testis. As deletion of Enhancer 13 (Enh13) of the Sox9 gene results in XY male-to-female sex reversal, we explored the critical elements necessary for its function and hence, for testis and male d...

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Veröffentlicht in:	Nucleic acids research 2024-06, Vol.52 (10), p.5514-5528
Hauptverfasser:	Ridnik, Meshi, Abberbock, Elisheva, Alipov, Veronica, Lhermann, Shelly Ziv, Kaufman, Shoham, Lubman, Maor, Poulat, Francis, Gonen, Nitzan
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene regulation, Chromatin and Epigenetics Life Sciences
Online-Zugang:	Volltext
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