A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study
A knowledge gap exists regarding the association between vitiligo and rheumatoid arthritis (RA) due to the absence of large-scale cohort studies designed to investigate this association. To investigate the bidirectional epidemiological association between vitiligo and RA. A population-based study wa...
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| Veröffentlicht in: | Archives of Dermatological Research 2024-06, Vol.316 (7), p.366, Article 366 |
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| description | A knowledge gap exists regarding the association between vitiligo and rheumatoid arthritis (RA) due to the absence of large-scale cohort studies designed to investigate this association. To investigate the bidirectional epidemiological association between vitiligo and RA. A population-based study was conducted using Clalit Health Services (CHS) database (2002–2019) using both a cohort study and a case-control study design. Adjusted hazard ratio (HR) and odds ratio (OR) were calculated by multivariate Cox and logistic regressions, respectively. Overall, 20,851 vitiligo patients and 102,475 controls were included. The incidence of new-onset RA was 4.1 (95% CI 3.0–5.4) and 2.9 (95% CI 2.4–3.3) cases per 10,000 person-years among patients with vitiligo and controls, respectively. Patients with vitiligo had a significantly increased risk of developing new-onset RA (adjusted HR, 1.44; 95% confidence interval [CI], 1.02–2.02,
P
= 0.036). The likelihood of having vitiligo was significantly elevated after a preexisting diagnosis of RA (adjusted OR, 1.67; 95% CI, 1.38–2.03;
P
|
| doi_str_mv | 10.1007/s00403-024-02965-7 |
| format | Article |
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P
= 0.036). The likelihood of having vitiligo was significantly elevated after a preexisting diagnosis of RA (adjusted OR, 1.67; 95% CI, 1.38–2.03;
P
< 0.001). Relative to the remaining patients with vitiligo, those with vitiligo and comorbid RA demonstrated an elevated risk of all-cause mortality (adjusted HR, 1.61; 95% CI, 1.03–2.51;
P
= 0.037). Our study confirms the bidirectional association between vitiligo and RA. Physicians treating patients with vitiligo should be aware of the association in clinical practice.</description><identifier>ISSN: 1432-069X</identifier><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-024-02965-7</identifier><identifier>PMID: 38850409</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - epidemiology ; Case-Control Studies ; Databases, Factual ; Dermatology ; Epidemiology ; Female ; Humans ; Incidence ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Paper ; Patients ; Population studies ; Population-based studies ; Rheumatoid arthritis ; Risk Factors ; Taiwan - epidemiology ; Vitiligo ; Vitiligo - epidemiology</subject><ispartof>Archives of Dermatological Research, 2024-06, Vol.316 (7), p.366, Article 366</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-61c4fa864a61e39e8da3f2b36c7175162546ffb7f03668400927fcc7298ab4743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-024-02965-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-024-02965-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38850409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Naama Tova</creatorcontrib><creatorcontrib>Schonmann, Yochai</creatorcontrib><creatorcontrib>Kridin, Khalaf</creatorcontrib><title>A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>A knowledge gap exists regarding the association between vitiligo and rheumatoid arthritis (RA) due to the absence of large-scale cohort studies designed to investigate this association. To investigate the bidirectional epidemiological association between vitiligo and RA. A population-based study was conducted using Clalit Health Services (CHS) database (2002–2019) using both a cohort study and a case-control study design. Adjusted hazard ratio (HR) and odds ratio (OR) were calculated by multivariate Cox and logistic regressions, respectively. Overall, 20,851 vitiligo patients and 102,475 controls were included. The incidence of new-onset RA was 4.1 (95% CI 3.0–5.4) and 2.9 (95% CI 2.4–3.3) cases per 10,000 person-years among patients with vitiligo and controls, respectively. Patients with vitiligo had a significantly increased risk of developing new-onset RA (adjusted HR, 1.44; 95% confidence interval [CI], 1.02–2.02,
P
= 0.036). The likelihood of having vitiligo was significantly elevated after a preexisting diagnosis of RA (adjusted OR, 1.67; 95% CI, 1.38–2.03;
P
< 0.001). Relative to the remaining patients with vitiligo, those with vitiligo and comorbid RA demonstrated an elevated risk of all-cause mortality (adjusted HR, 1.61; 95% CI, 1.03–2.51;
P
= 0.037). Our study confirms the bidirectional association between vitiligo and RA. Physicians treating patients with vitiligo should be aware of the association in clinical practice.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - epidemiology</subject><subject>Case-Control Studies</subject><subject>Databases, Factual</subject><subject>Dermatology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Rheumatoid arthritis</subject><subject>Risk Factors</subject><subject>Taiwan - epidemiology</subject><subject>Vitiligo</subject><subject>Vitiligo - epidemiology</subject><issn>1432-069X</issn><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1rFTEYhQdR7If-ARcScONmNJlkkowbKUWrUHCj4C68k3nn3pTM5JqPlv57c721VhcuQgLnOedNcprmBaNvGKXqbaJUUN7STtQ1yL5Vj5pjJnjXUjl8f_zgfNScpHRFq0lp9rQ54lr31TscN_GMjG5yEW12YQVPoOTglqWsSKwvKWMkI-YbxJVcu-y82wQC60TiFssClZ0IxLyNVUvvCBAPcYNtsuCR7MKueNgHtyMknEjKZbp91jyZwSd8frefNt8-fvh6_qm9_HLx-fzssrWik7mVzIoZtBQgGfIB9QR87kYurWKqZ7LrhZznUc2US6kFpUOnZmtVN2gYhRL8tHl_yN2VccHJ4pojeLOLboF4awI487eyuq3ZhGvDWE3nWtaE13cJMfwomLJZXLLoPawYSjKcyn5QutO0oq_-Qa9CifVDK8VqQ1xqpirVHSgbQ0oR5_vbMGr2nZpDp6Y6zK9Ozd708uE77i2_S6wAPwCpSusG45_Z_4n9CVkKrt8</recordid><startdate>20240608</startdate><enddate>20240608</enddate><creator>Cohen, Naama Tova</creator><creator>Schonmann, Yochai</creator><creator>Kridin, Khalaf</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240608</creationdate><title>A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study</title><author>Cohen, Naama Tova ; Schonmann, Yochai ; Kridin, Khalaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-61c4fa864a61e39e8da3f2b36c7175162546ffb7f03668400927fcc7298ab4743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - epidemiology</topic><topic>Case-Control Studies</topic><topic>Databases, Factual</topic><topic>Dermatology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Rheumatoid arthritis</topic><topic>Risk Factors</topic><topic>Taiwan - epidemiology</topic><topic>Vitiligo</topic><topic>Vitiligo - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Naama Tova</creatorcontrib><creatorcontrib>Schonmann, Yochai</creatorcontrib><creatorcontrib>Kridin, Khalaf</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Naama Tova</au><au>Schonmann, Yochai</au><au>Kridin, Khalaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2024-06-08</date><risdate>2024</risdate><volume>316</volume><issue>7</issue><spage>366</spage><pages>366-</pages><artnum>366</artnum><issn>1432-069X</issn><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>A knowledge gap exists regarding the association between vitiligo and rheumatoid arthritis (RA) due to the absence of large-scale cohort studies designed to investigate this association. To investigate the bidirectional epidemiological association between vitiligo and RA. A population-based study was conducted using Clalit Health Services (CHS) database (2002–2019) using both a cohort study and a case-control study design. Adjusted hazard ratio (HR) and odds ratio (OR) were calculated by multivariate Cox and logistic regressions, respectively. Overall, 20,851 vitiligo patients and 102,475 controls were included. The incidence of new-onset RA was 4.1 (95% CI 3.0–5.4) and 2.9 (95% CI 2.4–3.3) cases per 10,000 person-years among patients with vitiligo and controls, respectively. Patients with vitiligo had a significantly increased risk of developing new-onset RA (adjusted HR, 1.44; 95% confidence interval [CI], 1.02–2.02,
P
= 0.036). The likelihood of having vitiligo was significantly elevated after a preexisting diagnosis of RA (adjusted OR, 1.67; 95% CI, 1.38–2.03;
P
< 0.001). Relative to the remaining patients with vitiligo, those with vitiligo and comorbid RA demonstrated an elevated risk of all-cause mortality (adjusted HR, 1.61; 95% CI, 1.03–2.51;
P
= 0.037). Our study confirms the bidirectional association between vitiligo and RA. Physicians treating patients with vitiligo should be aware of the association in clinical practice.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38850409</pmid><doi>10.1007/s00403-024-02965-7</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - epidemiology Case-Control Studies Databases, Factual Dermatology Epidemiology Female Humans Incidence Male Medicine Medicine & Public Health Middle Aged Original Paper Patients Population studies Population-based studies Rheumatoid arthritis Risk Factors Taiwan - epidemiology Vitiligo Vitiligo - epidemiology |
| title | A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study |
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