Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma
Malignant rhabdoid tumors (MRT) show a multiphenotypic diversity, including a neural phenotype. To elucidate the difference in neural characteristics between MRT and neuroblastoma, we examined the expression of synapsin I, neuron‐restrictive silencer factor (NRSF), neurofilament medium‐size (NF‐M) a...
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| Veröffentlicht in: | Cancer science 2003-01, Vol.94 (1), p.37-42 |
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| creator | Higashino, Katsumi Narita, Tsutomu Taga, Takashi Ohta, Shigeru Takeuchi, Yoshihiro |
| description | Malignant rhabdoid tumors (MRT) show a multiphenotypic diversity, including a neural phenotype. To elucidate the difference in neural characteristics between MRT and neuroblastoma, we examined the expression of synapsin I, neuron‐restrictive silencer factor (NRSF), neurofilament medium‐size (NF‐M) and chromogranin A (CGA) in five MRT cell lines (TM87–16, STM91–01, TTC549, TTC642 and YAM‐RTK1) and five neuroblastoma cell lines under differentiation‐induction with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Our results showed TM87–16 and TTC642 cells, expressed synapsin I and NF‐M before TPA induction, had a neural phenotype. After differentiation‐induction, only TM87–16 cells expressed CGA. Among all neuroblastoma cells, expression of NF‐M and CGA was stable at a high level throughout TPA‐induced differentiation. In TM87–16 and TTC642 MRT cells, synapsin I mRNA promptly increased after TPA differentiation, with the peak level at 6 h, and thereafter, synapsin I mRNA rapidly decreased in a time‐dependent manner. The decreased expression of synapsin I correlated with an increased expression of NRSF during differentiation‐induction. In contrast, in some neuroblastoma cells, a significant up‐regulation of synapsin I was observed concurrently with a down‐regulation of NRSF. The inverse relationship between NRSF and synapsin I expression in TM87–16 and TTC642 MRT cells was opposite to that of neuroblastoma cells. Our results showed that the neural characteristics of these MRT cells are fairly distinct from those of neuroblastoma cells. These MRT cells appeared to have only limited capability for neural differentiation, and were still in an extremely early stage of neural differentiation. (Cancer Sci 2003; 94: 37–42) |
| doi_str_mv | 10.1111/j.1349-7006.2003.tb01349.x |
| format | Article |
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To elucidate the difference in neural characteristics between MRT and neuroblastoma, we examined the expression of synapsin I, neuron‐restrictive silencer factor (NRSF), neurofilament medium‐size (NF‐M) and chromogranin A (CGA) in five MRT cell lines (TM87–16, STM91–01, TTC549, TTC642 and YAM‐RTK1) and five neuroblastoma cell lines under differentiation‐induction with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Our results showed TM87–16 and TTC642 cells, expressed synapsin I and NF‐M before TPA induction, had a neural phenotype. After differentiation‐induction, only TM87–16 cells expressed CGA. Among all neuroblastoma cells, expression of NF‐M and CGA was stable at a high level throughout TPA‐induced differentiation. In TM87–16 and TTC642 MRT cells, synapsin I mRNA promptly increased after TPA differentiation, with the peak level at 6 h, and thereafter, synapsin I mRNA rapidly decreased in a time‐dependent manner. The decreased expression of synapsin I correlated with an increased expression of NRSF during differentiation‐induction. In contrast, in some neuroblastoma cells, a significant up‐regulation of synapsin I was observed concurrently with a down‐regulation of NRSF. The inverse relationship between NRSF and synapsin I expression in TM87–16 and TTC642 MRT cells was opposite to that of neuroblastoma cells. Our results showed that the neural characteristics of these MRT cells are fairly distinct from those of neuroblastoma cells. These MRT cells appeared to have only limited capability for neural differentiation, and were still in an extremely early stage of neural differentiation. (Cancer Sci 2003; 94: 37–42)</description><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2003.tb01349.x</identifier><identifier>PMID: 12708472</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetic acid ; Biological and medical sciences ; Cell differentiation ; Cell Differentiation - drug effects ; Chromogranin A ; Chromogranins - analysis ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic - drug effects ; In Situ Hybridization ; Malignant rhabdoid tumor ; Medical sciences ; mRNA ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Neuroblastoma ; Neuroblastoma - genetics ; Neuroblastoma - metabolism ; Neuroblastoma - pathology ; Neuroblastoma cells ; Neurofilament Proteins - analysis ; Neurology ; Neurons - chemistry ; Phenotypes ; Regulatory sequences ; Repressor Proteins - analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Rhabdoid Tumor - genetics ; Rhabdoid Tumor - metabolism ; Rhabdoid Tumor - pathology ; RNA, Messenger - biosynthesis ; RNA, Neoplasm - biosynthesis ; Synapsin I ; Synapsins - analysis ; Tetradecanoylphorbol Acetate - pharmacology ; Transcription Factors - analysis ; Tumor Cells, Cultured - drug effects ; Tumor Cells, Cultured - metabolism ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Cancer science, 2003-01, Vol.94 (1), p.37-42</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Jan 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5887-ba58b199187bfd9a4708b61d71b7e111bedf99866b0c92dd26444ebf42a2e12a3</citedby><cites>FETCH-LOGICAL-c5887-ba58b199187bfd9a4708b61d71b7e111bedf99866b0c92dd26444ebf42a2e12a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160256/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160256/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,11561,27923,27924,45573,45574,46051,46475,53790,53792</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2003.tb01349.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15261200$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12708472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higashino, Katsumi</creatorcontrib><creatorcontrib>Narita, Tsutomu</creatorcontrib><creatorcontrib>Taga, Takashi</creatorcontrib><creatorcontrib>Ohta, Shigeru</creatorcontrib><creatorcontrib>Takeuchi, Yoshihiro</creatorcontrib><title>Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Malignant rhabdoid tumors (MRT) show a multiphenotypic diversity, including a neural phenotype. To elucidate the difference in neural characteristics between MRT and neuroblastoma, we examined the expression of synapsin I, neuron‐restrictive silencer factor (NRSF), neurofilament medium‐size (NF‐M) and chromogranin A (CGA) in five MRT cell lines (TM87–16, STM91–01, TTC549, TTC642 and YAM‐RTK1) and five neuroblastoma cell lines under differentiation‐induction with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Our results showed TM87–16 and TTC642 cells, expressed synapsin I and NF‐M before TPA induction, had a neural phenotype. After differentiation‐induction, only TM87–16 cells expressed CGA. Among all neuroblastoma cells, expression of NF‐M and CGA was stable at a high level throughout TPA‐induced differentiation. In TM87–16 and TTC642 MRT cells, synapsin I mRNA promptly increased after TPA differentiation, with the peak level at 6 h, and thereafter, synapsin I mRNA rapidly decreased in a time‐dependent manner. The decreased expression of synapsin I correlated with an increased expression of NRSF during differentiation‐induction. In contrast, in some neuroblastoma cells, a significant up‐regulation of synapsin I was observed concurrently with a down‐regulation of NRSF. The inverse relationship between NRSF and synapsin I expression in TM87–16 and TTC642 MRT cells was opposite to that of neuroblastoma cells. Our results showed that the neural characteristics of these MRT cells are fairly distinct from those of neuroblastoma cells. These MRT cells appeared to have only limited capability for neural differentiation, and were still in an extremely early stage of neural differentiation. (Cancer Sci 2003; 94: 37–42)</description><subject>Acetic acid</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - drug effects</subject><subject>Chromogranin A</subject><subject>Chromogranins - analysis</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>In Situ Hybridization</subject><subject>Malignant rhabdoid tumor</subject><subject>Medical sciences</subject><subject>mRNA</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Neuroblastoma</subject><subject>Neuroblastoma - genetics</subject><subject>Neuroblastoma - metabolism</subject><subject>Neuroblastoma - pathology</subject><subject>Neuroblastoma cells</subject><subject>Neurofilament Proteins - analysis</subject><subject>Neurology</subject><subject>Neurons - chemistry</subject><subject>Phenotypes</subject><subject>Regulatory sequences</subject><subject>Repressor Proteins - analysis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rhabdoid Tumor - genetics</subject><subject>Rhabdoid Tumor - metabolism</subject><subject>Rhabdoid Tumor - pathology</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Neoplasm - biosynthesis</subject><subject>Synapsin I</subject><subject>Synapsins - analysis</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Transcription Factors - analysis</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Cells, Cultured - metabolism</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>1347-9032</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkdFv1SAUxonRuHn1XzCNRt9agVJoTYxZbjY1mfFBfTTkUGCXmxYmtG7776W7zaa-yQvknN_5-E4-hF4QXJF83uwrUrOuFBjzimJcV5PCS6W6foCO71oPb9-i7HBNj9CTlPYZ5axjj9ERoQK3TNBj9OMzDO7Cg5-KuAOlg9PFNI8hFmkXrlIBxezdz9kU3swRhkI7a000fnIwueALSLmUJuf7qbAxjLdcUAOkKYzwFD2yMCTzbL036PvZ6bftx_L8y4dP25Pzsm_aVpQKmlaRriOtUFZ3wLI7xYkWRAmTN1ZG265rOVe476jWlDPGjLKMAjWEQr1B7w-6l7Maje6zv2xWXkY3QryRAZz8u-PdTl6EXzKLc0wbnhVerwox5HXTJEeXejMM4E2YkxQ1pYSTJoMv_wH3YY4-bycpw5hQXrc0U28PVB9DStHYOy8EL58SuZdLUnJJSi4hyjVEeZ2Hn_-5zf3omloGXq0ApB4GG8H3Lt1zDeVk0dygdwfuyg3m5j8syO3J11rUvwF9oLsL</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Higashino, Katsumi</creator><creator>Narita, Tsutomu</creator><creator>Taga, Takashi</creator><creator>Ohta, Shigeru</creator><creator>Takeuchi, Yoshihiro</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200301</creationdate><title>Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma</title><author>Higashino, Katsumi ; Narita, Tsutomu ; Taga, Takashi ; Ohta, Shigeru ; Takeuchi, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5887-ba58b199187bfd9a4708b61d71b7e111bedf99866b0c92dd26444ebf42a2e12a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acetic acid</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation</topic><topic>Cell Differentiation - drug effects</topic><topic>Chromogranin A</topic><topic>Chromogranins - analysis</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>In Situ Hybridization</topic><topic>Malignant rhabdoid tumor</topic><topic>Medical sciences</topic><topic>mRNA</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Neuroblastoma</topic><topic>Neuroblastoma - genetics</topic><topic>Neuroblastoma - metabolism</topic><topic>Neuroblastoma - pathology</topic><topic>Neuroblastoma cells</topic><topic>Neurofilament Proteins - analysis</topic><topic>Neurology</topic><topic>Neurons - chemistry</topic><topic>Phenotypes</topic><topic>Regulatory sequences</topic><topic>Repressor Proteins - analysis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Rhabdoid Tumor - genetics</topic><topic>Rhabdoid Tumor - metabolism</topic><topic>Rhabdoid Tumor - pathology</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Neoplasm - biosynthesis</topic><topic>Synapsin I</topic><topic>Synapsins - analysis</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Transcription Factors - analysis</topic><topic>Tumor Cells, Cultured - drug effects</topic><topic>Tumor Cells, Cultured - metabolism</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higashino, Katsumi</creatorcontrib><creatorcontrib>Narita, Tsutomu</creatorcontrib><creatorcontrib>Taga, Takashi</creatorcontrib><creatorcontrib>Ohta, Shigeru</creatorcontrib><creatorcontrib>Takeuchi, Yoshihiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Higashino, Katsumi</au><au>Narita, Tsutomu</au><au>Taga, Takashi</au><au>Ohta, Shigeru</au><au>Takeuchi, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2003-01</date><risdate>2003</risdate><volume>94</volume><issue>1</issue><spage>37</spage><epage>42</epage><pages>37-42</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>Malignant rhabdoid tumors (MRT) show a multiphenotypic diversity, including a neural phenotype. To elucidate the difference in neural characteristics between MRT and neuroblastoma, we examined the expression of synapsin I, neuron‐restrictive silencer factor (NRSF), neurofilament medium‐size (NF‐M) and chromogranin A (CGA) in five MRT cell lines (TM87–16, STM91–01, TTC549, TTC642 and YAM‐RTK1) and five neuroblastoma cell lines under differentiation‐induction with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Our results showed TM87–16 and TTC642 cells, expressed synapsin I and NF‐M before TPA induction, had a neural phenotype. After differentiation‐induction, only TM87–16 cells expressed CGA. Among all neuroblastoma cells, expression of NF‐M and CGA was stable at a high level throughout TPA‐induced differentiation. In TM87–16 and TTC642 MRT cells, synapsin I mRNA promptly increased after TPA differentiation, with the peak level at 6 h, and thereafter, synapsin I mRNA rapidly decreased in a time‐dependent manner. The decreased expression of synapsin I correlated with an increased expression of NRSF during differentiation‐induction. In contrast, in some neuroblastoma cells, a significant up‐regulation of synapsin I was observed concurrently with a down‐regulation of NRSF. The inverse relationship between NRSF and synapsin I expression in TM87–16 and TTC642 MRT cells was opposite to that of neuroblastoma cells. Our results showed that the neural characteristics of these MRT cells are fairly distinct from those of neuroblastoma cells. These MRT cells appeared to have only limited capability for neural differentiation, and were still in an extremely early stage of neural differentiation. (Cancer Sci 2003; 94: 37–42)</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12708472</pmid><doi>10.1111/j.1349-7006.2003.tb01349.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer science, 2003-01, Vol.94 (1), p.37-42 |
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| subjects | Acetic acid Biological and medical sciences Cell differentiation Cell Differentiation - drug effects Chromogranin A Chromogranins - analysis Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects In Situ Hybridization Malignant rhabdoid tumor Medical sciences mRNA Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma cells Neurofilament Proteins - analysis Neurology Neurons - chemistry Phenotypes Regulatory sequences Repressor Proteins - analysis Reverse Transcriptase Polymerase Chain Reaction Rhabdoid Tumor - genetics Rhabdoid Tumor - metabolism Rhabdoid Tumor - pathology RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Synapsin I Synapsins - analysis Tetradecanoylphorbol Acetate - pharmacology Transcription Factors - analysis Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumors Tumors of the nervous system. Phacomatoses |
| title | Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma |
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