Tumor hypoxia: A target for selective cancer therapy

Tumor hypoxia has been considered to be a potential therapeutic problem because it renders solid tumors more resistant to sparsely ionizing radiation (IR) and chemotherapeutic drugs. Moreover, recent laboratory and clinical data have shown that tumor hypoxia is also associated with a more malignant...

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Veröffentlicht in:	Cancer science 2003-12, Vol.94 (12), p.1021-1028
Hauptverfasser:	Kizaka‐Kondoh, Shinae, Inoue, Masahiro, Harada, Hiroshi, Hiraoka, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Blood vessels Cancer therapies Cell Hypoxia Cytotoxicity Gene Expression Genetic Therapy - methods Humans Hypoxia Hypoxia-Inducible Factor 1 Ionizing radiation Medical sciences Neoplasms - blood supply Neoplasms - therapy Phenotypes Recombinant Fusion Proteins - therapeutic use Review Solid tumors Tumor cells Tumors
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