Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma
Uterine carcinosarcoma histologically comprises the components of epithelial and mesenchymal malignancies, and is known to be clinically highly aggressive. To reveal the significance of the expression of tyrosine‐kinase‐receptor‐type oncoproteins in this tumor type, the incidence and distribution of...
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| Veröffentlicht in: | Cancer science 2003-11, Vol.94 (11), p.986-991 |
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| creator | Sawada, Morio Tsuda, Hitoshi Kimura, Mikihiko Okamoto, Sanshiro Kita, Tsunekazu Kasamatsu, Takahiro Yamada, Takuro Kikuchi, Yoshihiro Honjo, Hideo Matsubara, Osamu |
| description | Uterine carcinosarcoma histologically comprises the components of epithelial and mesenchymal malignancies, and is known to be clinically highly aggressive. To reveal the significance of the expression of tyrosine‐kinase‐receptor‐type oncoproteins in this tumor type, the incidence and distribution of the KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins were immunohistochemically examined in 16 surgically resected cases. For 6 cases, the EGFR and HER‐2 amplifications were also examined by fluorescence in situ hybridization (FISH). In the epithelial component, overexpressions of KIT, EGFR, and HER‐2 were detected in 4 (25%), 5 (31%), and 9 (56%) cases, respectively, whereas these overexpressions in the mesenchymal component were detected in 6 (38%), 8 (50%), and 1 (6%) cases, respectively. KIT and EGFR were co‐overexpressed in the mesenchymal component of 4 cases and in the epithelial component of 2 cases. However, HER‐2 overexpression was mostly detected in the epithelial component only, and tended to occur independently of KIT and/or EGFR overexpression. By FISH, one of the 4 cases with HER‐2 overexpression showed low‐level gene amplification. In two cases with EGFR overexpression, the gain of EGFR alleles and/or polyploidization of chromosome 7 had occurred. The expression patterns of KIT, EGFR, and HER‐2 differed between the epithelial and mesenchymal components, and the regulation of their expression appeared important in the acquisition of mesenchymal metaplasia in uterine carcinosarcoma. Structural and/or numerical alterations of chromosomes might be in part involved in EGFR and/or HER‐2 overexpression in this tumor type. |
| doi_str_mv | 10.1111/j.1349-7006.2003.tb01389.x |
| format | Article |
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To reveal the significance of the expression of tyrosine‐kinase‐receptor‐type oncoproteins in this tumor type, the incidence and distribution of the KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins were immunohistochemically examined in 16 surgically resected cases. For 6 cases, the EGFR and HER‐2 amplifications were also examined by fluorescence in situ hybridization (FISH). In the epithelial component, overexpressions of KIT, EGFR, and HER‐2 were detected in 4 (25%), 5 (31%), and 9 (56%) cases, respectively, whereas these overexpressions in the mesenchymal component were detected in 6 (38%), 8 (50%), and 1 (6%) cases, respectively. KIT and EGFR were co‐overexpressed in the mesenchymal component of 4 cases and in the epithelial component of 2 cases. However, HER‐2 overexpression was mostly detected in the epithelial component only, and tended to occur independently of KIT and/or EGFR overexpression. By FISH, one of the 4 cases with HER‐2 overexpression showed low‐level gene amplification. In two cases with EGFR overexpression, the gain of EGFR alleles and/or polyploidization of chromosome 7 had occurred. The expression patterns of KIT, EGFR, and HER‐2 differed between the epithelial and mesenchymal components, and the regulation of their expression appeared important in the acquisition of mesenchymal metaplasia in uterine carcinosarcoma. Structural and/or numerical alterations of chromosomes might be in part involved in EGFR and/or HER‐2 overexpression in this tumor type.</description><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2003.tb01389.x</identifier><identifier>PMID: 14611676</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Carcinosarcoma - genetics ; Carcinosarcoma - metabolism ; Carcinosarcoma - surgery ; Chondrosarcoma, Mesenchymal - genetics ; Chondrosarcoma, Mesenchymal - metabolism ; Chondrosarcoma, Mesenchymal - surgery ; Chromosome 7 ; Epidermal growth factor receptors ; ErbB protein ; ErbB Receptors - genetics ; ErbB Receptors - metabolism ; Female ; Fluorescence in situ hybridization ; Gene Amplification ; Humans ; Hysterectomy ; Immunoenzyme Techniques ; In Situ Hybridization, Fluorescence ; Medical sciences ; Mesenchyme ; Metaplasia ; Neoplasms, Glandular and Epithelial - genetics ; Neoplasms, Glandular and Epithelial - metabolism ; Neoplasms, Glandular and Epithelial - surgery ; Oncoproteins ; Polyploidy ; Proto-Oncogene Proteins c-kit - genetics ; Proto-Oncogene Proteins c-kit - metabolism ; Receptor, ErbB-2 - genetics ; Receptor, ErbB-2 - metabolism ; Tumors ; Uterine Neoplasms - genetics ; Uterine Neoplasms - metabolism ; Uterine Neoplasms - surgery ; Uterus</subject><ispartof>Cancer science, 2003-11, Vol.94 (11), p.986-991</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Nov 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6866-570dbff72a5ca7ea640e0082267cc38e86019badf684ebf4766d7f8614253d603</citedby><cites>FETCH-LOGICAL-c6866-570dbff72a5ca7ea640e0082267cc38e86019badf684ebf4766d7f8614253d603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160179/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160179/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2003.tb01389.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15764594$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14611676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawada, Morio</creatorcontrib><creatorcontrib>Tsuda, Hitoshi</creatorcontrib><creatorcontrib>Kimura, Mikihiko</creatorcontrib><creatorcontrib>Okamoto, Sanshiro</creatorcontrib><creatorcontrib>Kita, Tsunekazu</creatorcontrib><creatorcontrib>Kasamatsu, Takahiro</creatorcontrib><creatorcontrib>Yamada, Takuro</creatorcontrib><creatorcontrib>Kikuchi, Yoshihiro</creatorcontrib><creatorcontrib>Honjo, Hideo</creatorcontrib><creatorcontrib>Matsubara, Osamu</creatorcontrib><title>Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Uterine carcinosarcoma histologically comprises the components of epithelial and mesenchymal malignancies, and is known to be clinically highly aggressive. To reveal the significance of the expression of tyrosine‐kinase‐receptor‐type oncoproteins in this tumor type, the incidence and distribution of the KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins were immunohistochemically examined in 16 surgically resected cases. For 6 cases, the EGFR and HER‐2 amplifications were also examined by fluorescence in situ hybridization (FISH). In the epithelial component, overexpressions of KIT, EGFR, and HER‐2 were detected in 4 (25%), 5 (31%), and 9 (56%) cases, respectively, whereas these overexpressions in the mesenchymal component were detected in 6 (38%), 8 (50%), and 1 (6%) cases, respectively. KIT and EGFR were co‐overexpressed in the mesenchymal component of 4 cases and in the epithelial component of 2 cases. However, HER‐2 overexpression was mostly detected in the epithelial component only, and tended to occur independently of KIT and/or EGFR overexpression. By FISH, one of the 4 cases with HER‐2 overexpression showed low‐level gene amplification. In two cases with EGFR overexpression, the gain of EGFR alleles and/or polyploidization of chromosome 7 had occurred. The expression patterns of KIT, EGFR, and HER‐2 differed between the epithelial and mesenchymal components, and the regulation of their expression appeared important in the acquisition of mesenchymal metaplasia in uterine carcinosarcoma. Structural and/or numerical alterations of chromosomes might be in part involved in EGFR and/or HER‐2 overexpression in this tumor type.</description><subject>Biological and medical sciences</subject><subject>Carcinosarcoma - genetics</subject><subject>Carcinosarcoma - metabolism</subject><subject>Carcinosarcoma - surgery</subject><subject>Chondrosarcoma, Mesenchymal - genetics</subject><subject>Chondrosarcoma, Mesenchymal - metabolism</subject><subject>Chondrosarcoma, Mesenchymal - surgery</subject><subject>Chromosome 7</subject><subject>Epidermal growth factor receptors</subject><subject>ErbB protein</subject><subject>ErbB Receptors - genetics</subject><subject>ErbB Receptors - metabolism</subject><subject>Female</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene Amplification</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Immunoenzyme Techniques</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Medical sciences</subject><subject>Mesenchyme</subject><subject>Metaplasia</subject><subject>Neoplasms, Glandular and Epithelial - genetics</subject><subject>Neoplasms, Glandular and Epithelial - metabolism</subject><subject>Neoplasms, Glandular and Epithelial - surgery</subject><subject>Oncoproteins</subject><subject>Polyploidy</subject><subject>Proto-Oncogene Proteins c-kit - genetics</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Tumors</subject><subject>Uterine Neoplasms - genetics</subject><subject>Uterine Neoplasms - metabolism</subject><subject>Uterine Neoplasms - surgery</subject><subject>Uterus</subject><issn>1347-9032</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqVks9u1DAQxiMEoqXwCsgCFYHUXew4sWMOoLJs_4hKSKWcLccZs14ldrCztHvjEbjzdjwJTnfVAheEL-ORfzPz2f6y7AnBU5LWy-WU0EJMOMZsmmNMp0ONCa3E9OpOtntzdPd6zycC03wnexDjMqGsEMX9bIcUjBDG2W724501BgK4AcFVHyBG6x3q1TBAcBF5g96fXhyg-fHR-QFSrkEn8_Of377n6LlOAUL9dsxeIO-074MfwKaqGoZLAIegt8MCWqva69IOIji9WHcp177rvUtjI7IOrdI06wBpFbR1PqbgO_Uwu2dUG-HRNu5ln47mF7OTydmH49PZ4dlEs4qxSclxUxvDc1VqxUGxAgPGVZ4zrjWtoGKYiFo1hlUF1KbgjDXcVIwUeUkbhule9mbTt1_VHTQ6qQqqlX2wnQpr6ZWVf544u5Cf_VeZPiP15iJ1eLbtEPyXFcRBdjZqaFvlwK-i5ISWCS7_CRKRs6oiRQKf_gUu_Sq49Awyp0IwSvJynPtqQ-ngYwxgbkQTPKojcilHQ8jREHL0itx6RV6l4se_X_u2dGuOBOxvARW1ak1QTtt4y5WcFaUYtb7ecJe2hfV_SJCzw4-iYvQXIxnf_w</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Sawada, Morio</creator><creator>Tsuda, Hitoshi</creator><creator>Kimura, Mikihiko</creator><creator>Okamoto, Sanshiro</creator><creator>Kita, Tsunekazu</creator><creator>Kasamatsu, Takahiro</creator><creator>Yamada, Takuro</creator><creator>Kikuchi, Yoshihiro</creator><creator>Honjo, Hideo</creator><creator>Matsubara, Osamu</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200311</creationdate><title>Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma</title><author>Sawada, Morio ; Tsuda, Hitoshi ; Kimura, Mikihiko ; Okamoto, Sanshiro ; Kita, Tsunekazu ; Kasamatsu, Takahiro ; Yamada, Takuro ; Kikuchi, Yoshihiro ; Honjo, Hideo ; Matsubara, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6866-570dbff72a5ca7ea640e0082267cc38e86019badf684ebf4766d7f8614253d603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Carcinosarcoma - genetics</topic><topic>Carcinosarcoma - metabolism</topic><topic>Carcinosarcoma - surgery</topic><topic>Chondrosarcoma, Mesenchymal - genetics</topic><topic>Chondrosarcoma, Mesenchymal - metabolism</topic><topic>Chondrosarcoma, Mesenchymal - surgery</topic><topic>Chromosome 7</topic><topic>Epidermal growth factor receptors</topic><topic>ErbB protein</topic><topic>ErbB Receptors - genetics</topic><topic>ErbB Receptors - metabolism</topic><topic>Female</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene Amplification</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Immunoenzyme Techniques</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Medical sciences</topic><topic>Mesenchyme</topic><topic>Metaplasia</topic><topic>Neoplasms, Glandular and Epithelial - genetics</topic><topic>Neoplasms, Glandular and Epithelial - metabolism</topic><topic>Neoplasms, Glandular and Epithelial - surgery</topic><topic>Oncoproteins</topic><topic>Polyploidy</topic><topic>Proto-Oncogene Proteins c-kit - genetics</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Tumors</topic><topic>Uterine Neoplasms - genetics</topic><topic>Uterine Neoplasms - metabolism</topic><topic>Uterine Neoplasms - surgery</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawada, Morio</creatorcontrib><creatorcontrib>Tsuda, Hitoshi</creatorcontrib><creatorcontrib>Kimura, Mikihiko</creatorcontrib><creatorcontrib>Okamoto, Sanshiro</creatorcontrib><creatorcontrib>Kita, Tsunekazu</creatorcontrib><creatorcontrib>Kasamatsu, Takahiro</creatorcontrib><creatorcontrib>Yamada, Takuro</creatorcontrib><creatorcontrib>Kikuchi, Yoshihiro</creatorcontrib><creatorcontrib>Honjo, Hideo</creatorcontrib><creatorcontrib>Matsubara, Osamu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sawada, Morio</au><au>Tsuda, Hitoshi</au><au>Kimura, Mikihiko</au><au>Okamoto, Sanshiro</au><au>Kita, Tsunekazu</au><au>Kasamatsu, Takahiro</au><au>Yamada, Takuro</au><au>Kikuchi, Yoshihiro</au><au>Honjo, Hideo</au><au>Matsubara, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2003-11</date><risdate>2003</risdate><volume>94</volume><issue>11</issue><spage>986</spage><epage>991</epage><pages>986-991</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>Uterine carcinosarcoma histologically comprises the components of epithelial and mesenchymal malignancies, and is known to be clinically highly aggressive. To reveal the significance of the expression of tyrosine‐kinase‐receptor‐type oncoproteins in this tumor type, the incidence and distribution of the KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins were immunohistochemically examined in 16 surgically resected cases. For 6 cases, the EGFR and HER‐2 amplifications were also examined by fluorescence in situ hybridization (FISH). In the epithelial component, overexpressions of KIT, EGFR, and HER‐2 were detected in 4 (25%), 5 (31%), and 9 (56%) cases, respectively, whereas these overexpressions in the mesenchymal component were detected in 6 (38%), 8 (50%), and 1 (6%) cases, respectively. KIT and EGFR were co‐overexpressed in the mesenchymal component of 4 cases and in the epithelial component of 2 cases. However, HER‐2 overexpression was mostly detected in the epithelial component only, and tended to occur independently of KIT and/or EGFR overexpression. By FISH, one of the 4 cases with HER‐2 overexpression showed low‐level gene amplification. In two cases with EGFR overexpression, the gain of EGFR alleles and/or polyploidization of chromosome 7 had occurred. The expression patterns of KIT, EGFR, and HER‐2 differed between the epithelial and mesenchymal components, and the regulation of their expression appeared important in the acquisition of mesenchymal metaplasia in uterine carcinosarcoma. Structural and/or numerical alterations of chromosomes might be in part involved in EGFR and/or HER‐2 overexpression in this tumor type.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14611676</pmid><doi>10.1111/j.1349-7006.2003.tb01389.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer science, 2003-11, Vol.94 (11), p.986-991 |
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| subjects | Biological and medical sciences Carcinosarcoma - genetics Carcinosarcoma - metabolism Carcinosarcoma - surgery Chondrosarcoma, Mesenchymal - genetics Chondrosarcoma, Mesenchymal - metabolism Chondrosarcoma, Mesenchymal - surgery Chromosome 7 Epidermal growth factor receptors ErbB protein ErbB Receptors - genetics ErbB Receptors - metabolism Female Fluorescence in situ hybridization Gene Amplification Humans Hysterectomy Immunoenzyme Techniques In Situ Hybridization, Fluorescence Medical sciences Mesenchyme Metaplasia Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - surgery Oncoproteins Polyploidy Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Tumors Uterine Neoplasms - genetics Uterine Neoplasms - metabolism Uterine Neoplasms - surgery Uterus |
| title | Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma |
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