Inhibition of peroxisome proliferator‐activated receptor γ activity suppresses pancreatic cancer cell motility

Peroxisome proliferator‐activated receptor γ (PPARγ) is a ligand‐activated transcription factor that has been implicated in the carcinogenesis and progression of various solid tumors, including pancreatic carcinomas. We aimed to clarify the role of this receptor in pancreatic cell motility in vitro...

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Veröffentlicht in:	Cancer science 2008-10, Vol.99 (10), p.1892-1900
Hauptverfasser:	Nakajima, Atsushi, Tomimoto, Ayako, Fujita, Koji, Sugiyama, Michiko, Takahashi, Hirokazu, Ikeda, Ikuko, Hosono, Kunihiro, Endo, Hiroki, Yoneda, Kyoko, Iida, Hiroshi, Inamori, Masahiko, Kubota, Kensuke, Saito, Satoru, Nakajima, Noriko, Wada, Koichiro, Nagashima, Yoji, Nakagama, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacology Biological and medical sciences Catenins cdc42 GTP-Binding Protein - metabolism Cell Adhesion Molecules - biosynthesis Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Delta Catenin Gastroenterology. Liver. Pancreas. Abdomen Humans Ligands Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, SCID Neoplasm Metastasis Original Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphoproteins - biosynthesis PPAR gamma - antagonists & inhibitors Pyridines - pharmacology rac1 GTP-Binding Protein - metabolism RNA, Small Interfering - metabolism Rosiglitazone Thiazolidinediones - pharmacology Tumors Xenograft Model Antitumor Assays
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