Proteasome inhibitor PS‐341 induces growth arrest and apoptosis of non‐small cell lung cancer cells via the JNK/c‐Jun/AP‐1 signaling

Proteasome inhibitor PS‐341 induces growth arrest and apoptosis of multiple myeloma (MM) cells via inactivation of NF‐κB in vitro and has afforded some objective responses in individuals with relapsed, refractory MM. However, the activity of PS‐341 against non‐hematological malignancies remains to b...

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Veröffentlicht in:	Cancer science 2004-02, Vol.95 (2), p.176-180
Hauptverfasser:	Yang, Yang, Ikezoe, Takeyuki, Saito, Tsuyako, Kobayashi, Makoto, Koeffler, H. Phillip, Taguchi, Hirokuni
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Boronic Acids - pharmacology Bortezomib Carcinoma, Non-Small-Cell Lung - drug therapy Cell Division - drug effects Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 Cyclins - drug effects Enzyme-Linked Immunosorbent Assay Genes, jun - drug effects GTP-binding protein Humans JNK Mitogen-Activated Protein Kinases Kinases Lung cancer Lung Neoplasms - drug therapy MAP Kinase Kinase 4 Medical sciences Mitogen-Activated Protein Kinase Kinases - drug effects Multiple myeloma Non-small cell lung carcinoma p53 Protein Phosphorylation Pneumology Proteasome inhibitors Proteins Proto-Oncogene Proteins c-bcl-2 - drug effects Pyrazines - pharmacology Signal Transduction - drug effects Small cell lung carcinoma Transcription Factor AP-1 - drug effects Tumor Suppressor Protein p53 - drug effects Tumors of the respiratory system and mediastinum Western blotting
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